Silvia von Karstedt
@vonkarstedtlab.bsky.social
Professor at University of Cologne, Germany, interested in cell death and cancer, nature enthusiast, secret musician, mum
☠️ Inducing cell death in pancreatic cancer cells @vonkarstedtlab.bsky.social has identified a new approach for treating particularly aggressive pancreatic cancer. It makes use of a genetic mutation that allows the immune system to attack the cancer cells again. Read more ▶️ uni.koeln/BUA8J
www.cmmc-uni-koeln.de/cmmc-news/sh...
Inducing Cell Death in Pancreatic Cancer Cells
A research team from the University of Cologne has identified a new approach for treating particularly aggressive pancreatic cancer. It makes use of a genetic mutation that allows the immune system to...
cmmc-uni-koeln.de
Our work now out @natcomms.nature.com: #PDAC is wired for #necroptosis due to oncogenic #KRAS. @unicologne.bsky.social @cecad.bsky.social @uniklinikkoeln.bsky.social with fantastic collaborators and superstar first author Sofya Tishina! rdcu.be/foDxS
Oncogenic KRAS-driven type I interferon signalling primes pancreatic cancer for necroptosis
Nature Communications - The regulatory roles of oncogenic KRAS in cell death pathways remain poorly understood. Here the authors report that KRAS induces a type I interferon response that primes...
rdcu.be
⚕️Ein Team der Pathologie der Uniklinik Köln hat das agentenbasierte KI-System SPARK entwickelt. Es verknüpft mehrere spezialisierte Algorithmen zu einem koordinierten System, das eigenständig biologische Hypothesen generieren, verfeinern und in analytische Werkzeuge umsetzen kann. ➡️ uni.koeln/BSZ8B
Künstliche Intelligenz in der Pathologie ermöglicht tieferes Verständnis von Tumorerkrankungen
Wissenschaftler*innen aus Köln haben ein Autonomes agentenbasiertes KI-System namens SPARK entwickelt, welches als „digitales Gehirn“ fungiert
uni.koeln
New preprint from the lab! Close collaboration with Silvia von Karstedt @vonkarstedtlab.bsky.social and her lab. We find that #SCLC cells are strikingly dependent on exogenous cysteine #LungCancer #CancerMetabolism #Ferroptosis 🧵 biorxiv.org/content/10.64898/2026.03.27.714827v1
Ever wondered how cellular #metabolism, #ROS, cellular confluence and #Ferroptosis are connected? Read our new study with theoretical physicist Johannes Berg @unicologne.bsky.social @cecad.bsky.social @uniklinikkoeln.bsky.social @dtg-cologne.bsky.social www.frontiersin.org/journals/cel...
Frontiers | A feedback loop between cell proliferation and ROS regulates ferroptosis sensitivity
BackgroundFerroptosis is a form of regulated cell death characterized by iron-dependent lipid peroxidation and membrane rupture. While cellular populations r...
frontiersin.org
🫁 Was macht das kleinzellige Lungenkarzinom (SCLC) so aggressiv? Forscher unter Leitung von @vonkarstedtlab.bsky.social vom @cecad.bsky.social / @unicologne.bsky.social haben einen neuen Mechanismus entdeckt, der dem #Lungenkrebs bei seiner Ausbreitung im Körper hilft. #SCLC
SCLC-Lungenkrebs: Wissenschafter entdecken wichtigen Mechanismus
Wissenschaftler der Universität zu Köln haben einen neuen Mechanismus entdeckt, der es ermöglicht, dass eine der aggressivsten Formen von Lungenkrebs der Behandlung entgeht, und eröffnet damit neue Mö...
healthcare-in-europe.com
Inflammation fuels one of the most aggressive forms of cancer www.idw-online.de/-DS52AA
Inflammation fuels one of the most aggressive forms of cancer
idw-online.de
A caspase 8 deletion #SCLC mouse model promotes a neuronal progenitor-like cell state and pre-tumoral immunosuppression triggered by #necroptosis that promotes metastasis @vonkarstedtlab.bsky.social @unicologne.bsky.social @dtg-cologne.bsky.social @cecad.bsky.social doi.org/10.1038/s414...
What a nice way to end 2025: absence of caspase 8 in #sclc leads to neuronal-like reprogramming and promotes #metastasis via #necroptosis driven #inflammatory response. Congratulations to Ariadne and collaborateurs @unicologne.bsky.social @dtg-cologne.bsky.social ! www.nature.com/articles/s41...
Lack of caspase 8 directs neuronal progenitor-like reprogramming and small cell lung cancer progression - Nature Communications
Caspase 8 protein expression is largely absent in small cell lung cancer (SCLC) patients. Here, the authors generate a caspase 8 deletion SCLC mouse model and show that it promotes a neuronal progenit...
nature.com
Happy to share an incredibly efficient collaboration with @gianmaria-liccardi.bsky.social : Ibrutinib cooperates with #ferroptosis induction to kill #dlbcl www.nature.com/articles/s41...
Redox destabilization by ibrutinib promotes ferroptosis in diffuse large B-cell lymphoma (DLBCL) - Cell Death Discovery
Cell Death Discovery - Redox destabilization by ibrutinib promotes ferroptosis in diffuse large B-cell lymphoma (DLBCL)
nature.com
The study titled “Functional synapses between neurons and small-cell lung cancer” was published in @nature.com 👇 www.nature.com/articles/s41... #unicologne #uniklöln @cecad.bsky.social #sclc #lungcancer #cancerresearch
Functional synapses between neurons and small cell lung cancer - Nature
Small cell lung cancer cells form functional synapses with glutamatergic neurons, receiving synaptic transmissions and deriving a proliferative advantage from these interactions.
nature.com
Signalling between neurons and tumour cells in the lung and brain promotes the growth of small-cell lung cancer go.nature.com/4gzoMmI
Wired for growth: neuron–tumour signalling in the lung and brain increases growth of a hard-to-treat cancer
Signalling between neurons and tumour cells in the lung and brain promotes the growth of small-cell lung cancer. These interactions might be a therapeutic target.
go.nature.com
Happy to start at Bluesky with a post on our recent manuscript at @nature.com: www.nature.com/articles/s41... Great collaboration with cool scientists such as @theprattgroup.bsky.social, @fedorovalab.bsky.social and many who do not (yet) have a Bluesky account.
Multiple oestradiol functions inhibit ferroptosis and acute kidney injury - Nature
17β-oestradiol establishes an anti-ferroptotic state in female kidney tubules.
nature.com
Hot topic in a hot environment! #FASEB @faseborg.bsky.social #Ferroptosis meeting organized by @olzmannlab.bsky.social and Scott Dixon is the place to be!
Come join us at this year's #FASEB conference on #Ferroptosis ! events.faseb.org/event/ferrop...
Ferroptosis, Oxidative Stress, and Lipid Metabolism
events.faseb.org
Today back to work from #maternityleave I found this left by my lovely team in my office @cecad.bsky.social
👏 Congratulations to Professor Aleksandra Trifunovic on receiving the Max Delbrück Research Prize 2025 from the University of Cologne for her groundbreaking work on #mitochondria, #aging, and cellular stress responses. A proud moment for #CECAD! ➡️ uni.koeln/Y6WSC @unicologne.bsky.social
Aleksandra Trifunovic receives Max Delbrück Research Prize 2025
CECAD congratulates Professor Aleksandra Trifunovic on receiving the University of Cologne’s Max Delbrück Prize for her pioneering contributions to mitochondrial biology.
uni.koeln
What do cells undergoing #ferroptosis #celldeath release? Read all about it in our atlas on ferroptosis #secretomes out now in Cell Death and Differentiation #CDDpress Great collaboration with @cecad.bsky.social @frezzalab.bsky.social @kreuzaler.bsky.social @almutschulze.bsky.social rdcu.be/ejp9C
An atlas of ferroptosis-induced secretomes
Cell Death & Differentiation - An atlas of ferroptosis-induced secretomes
rdcu.be
And this paper is coming to you live from #maternityleave with the right supportive network! Just wanted to encourage #womeninscience #youngparents
Ever wondered how #mitochondria fragmentation comes about during #ferroptosis ? Read our new paper on Drp1-mediated promotion of ferroptotic #celldeath. Great @cecad.bsky.social collaboration with Ana Garcia Saez! rdcu.be/d7L66
Ferroptosis triggers mitochondrial fragmentation via Drp1 activation
Cell Death & Disease - Ferroptosis triggers mitochondrial fragmentation via Drp1 activation
rdcu.be
Very pleased to see our latest study published at CDDpress. We show that #Seratrodast, an approved drug, is a suppressor of #ferroptosis by inihibiting lipid peroxidation. Thanks to Jule, Wulf, and the rest of the team! www.nature.com/articles/s41...
We strongly suggest that academic publishers and other platforms that host research rapidly implement a Share to Bluesky button for their articles. Here's how: docs.bsky.app/docs/advance... #AcademicSky #HigherEd #Altmetrics
Action Intent Links | Bluesky
Authors, websites, and apps can use action intent links to implement "Share on Bluesky" buttons, or similar in-app actions. Logged-in users will be directed to the corresponding action view in the Blu...
docs.bsky.app
Something always suspected now out in @natureportfolio.bsky.social Take home mesage: eat and be merry for life is too short to outsmarten #epigeneticmemory
Megan Dennis@mydennis.bsky.social · 2y agoNooooooo 😱 www.nature.com/articles/s41...
