Really happy to see our work published in JEM. The first big paper of our lab ! A big congratulations to Dovran Ovezfeldiyev, Vanessa Trefzer and Rory Doolan for their work on this story. Thank you to all our collaborators and especially Nicola Harris and Julia Esser-von Bieren.

Ovezgeldiyev, Trefzer, Doolan, @boucheryt.bsky.social et al. reveal a metabolic pathway linking lipid mediator production to #macrophage activation during #helminth immunity. rupress.org/jem/article/... #Metabolism #InnateImmunity #inflammation #InfectiousDisease #HostDefense

New 📽️ video summary by Danny Florez-Paz, on the study "C3 and CD47 mediate sensory-motor circuit refinement during spinal cord development" (rupress.org/jem/article/...) from the George Mentis lab (Columbia Motor Neuron Center @columbiauniversity.bsky.social): youtu.be/rLIF0vft17w

C3 and CD47 mediate sensory-motor refinement during spinal cord development

Original paper: https://rupress.org/jem/article/223/10/e20251329/283018/C3-and-CD47-mediate-sensory-motor-circuit Authors: Florez-Paz D and Mentis G.Z. Presenter: Danny Florez-Paz Key words:…

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“JEM doubtlessly is among the most prestigious journals in the overall field of medicine and in particular for the fields of immunology and inflammation.” — Ignacio Melero @unav.edu Learn more about submitting to a journal valued by the community for its impact and integrity. hubs.la/Q04wZhXq0

Upper respiratory tract #CD8⁺ tissue resident memory #Tcells protect against viral transmission. New study from Sarah E. Michalets, Jacob E. Kohlmeier and colleagues (Emory University): rupress.org/jem/article/... #InfectiousDisease #HostDefense #MucosalImmunology

Florez-Paz & Mentis demonstrate the presence of supernumerary synapses during development, resulting in miswired immature spinal circuits. Two molecularly distinct mechanisms are responsible for their refinement, incl. a surprising CD47-dependent mechanism rupress.org/jem/article/... #Neuroscience

Zhang et al. identify RalA-dependent signaling as a regulator of age-related #skeletalmuscle dysfunction. The novel compound UA-30 inhibits RalA activity, reduces muscle #fibrosis, improves mitochondrial function & mobility, & extends health span & survival in mice. rupress.org/jem/article/...

Vps4B controls caspase-1 dynamics at the ASC speck to drive #inflammasome activation. New study from Yanfeng Li, Qingqing Xie, Longjun Li, Xiaoqing Xu, Tao Xu, Xiaopeng Qi (Shandong University) and colleagues: rupress.org/jem/article/... #InfectiousDisease #HostDefense #InnateImmunity #inflammation

New content is available in our journal-based #CME activities @mskcme.bsky.social: 📄 “Serotype skewing and immune imprinting shape response to the tetravalent dengue virus Qdenga vaccine)” (Conde et al. doi.org/10.1084/jem....) Begin the activity 👉 mskcc.cloud-cme.com/course/cours...

TNFR1 expression on cancer cells mediates immune escape and an immunosuppressive microenvironment. New study from Elixabet Bolaños, Ignacio Melero @unav.edu and colleagues: rupress.org/jem/article/... #TumorImmunology

Explore our #cancer #Immunotherapy collection showcasing a broad range of topics, including the therapeutic potential of targeting cDC1, a strategy to harness the immunosuppressive potential of inhibitory receptors, targeting of inhibitory receptor agonists, and more: 👉 rupress.org/jem/collecti...

Human inherited RORγT deficiency encompasses genetic heterogeneity, T cell deficiency, and clinical homogeneity. New study from Iris Fagniez, Jean-Laurent Casanova @casanovalab.bsky.social, Rui Yang @ryangrui.bsky.social @rockefeller.edu & colleagues: rupress.org/jem/article/... #Immunodeficiency

The transcription factor IRF8 drives tumor-specific exhaustion in CD8⁺ T Cells. From Marco Ongaro, Grégory Verdeil and colleagues: rupress.org/jem/article/... Part of our #CancerImmunotherapy 2026 👉 rupress.org/jem/collecti... #CSHAsia

Michalets, Kohlmeier et al. demonstrate that upper respiratory tract tissue-resident memory #CD8⁺ T cells are sufficient to protect against respiratory virus transmission, even in the absence of #CD4 #Tcells, #Bcells, or lower respiratory tract immune responses. rupress.org/jem/article/...

JEM is pleased to present opportunities to engage in #CME @mskcme.bsky.social. The latest activity is now available 👉 mskcc.cloud-cme.com/course/cours... 📄 “Serotype skewing and immune imprinting shape response to the tetravalent dengue virus Qdenga vaccine” (Conde et al. doi.org/10.1084/jem....)

Intravesical mesothelin-based #CARTcells targeting MUC16 effectively control #BladderCancer in preclinical models. From Parwiz Abrahimi, Renier Brentjens, Jedd Wolchok, Taha Merghoub et al.: rupress.org/jem/article/... Part of our #CancerImmunotherapy 2026 👉 rupress.org/jem/collecti... #CSHAsia

New study by Li et al. identifies that the ATPase Vps4B controls caspase-1 dynamics at the ASC speck to promote #inflammasome activation. This self-rejuvenating mechanism of the ASC speck opens up new avenues for therapeutic intervention in inflammatory diseases. rupress.org/jem/article/...

Serotype skewing and immune imprinting shape response to the tetravalent #dengue virus #Qdenga #vaccine. From Luciana Conde, Valter Monteiro, Joao Freitas, Mauro Teixeira @ufmgbr.bsky.social, Carolina Lucas @carolilucas.bsky.social @yaleschoolofmed.bsky.social et al. rupress.org/jem/article/...

4/ @ryangrui.bsky.social completed his pediatric residency at Weill Cornell Pediatrics and his Allergy and Immunology fellowship at @bcmhouston.bsky.social and Texas Children’s Hospital. Our ongoing collaboration has yielded a study in @jem.org on RORγT deficiency rupress.org/jem/article/...

Human-inherited RORγT deficiency encompasses genetic heterogeneity, T cell deficiency, and clinical homogeneity

Fagniez et al. identify new patients with inherited RORγT deficiency characterized by impaired TCRα rearrangement, depletion of MAIT and iNKT cells, reduce

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@ostendorflab.org, @immushuang.bsky.social, @sohailtavazoie.bsky.social et al. show that activation of LXRs elicits a T cell "pre-effector" state that enhances priming and promotes anti-tumor immunity. rupress.org/jem/article/... In #CancerImmunotherapy 2026 👉 rupress.org/jem/collecti... #CSHAsia

CD1d remodels the tumor-infiltrating myeloid populations controlling anti-tumor immunity. From Lauren Evans, Maria Conde Poole, Patricia Barral @barrallab.bsky.social: rupress.org/jem/article/... Part of our #CancerImmunotherapy 2026 👉 rupress.org/jem/collecti... #CSHAsia

Bolaños, Melero et al. @unav.edu show that tumor necrosis factor sensing by cancer cells through TNFR1 sets in motion forms of immunosuppressive protumor #inflammation that mediate escape from immune surveillance against tumors. rupress.org/jem/article/... #TumorImmunology

Are you headed to @cshasia.bsky.social meeting on #cancer #immunotherapy in Suzhou? Meet our Deputy Editor, Gaia Trincucci (@gaiajexpmed.bsky.social), to discuss your research in person! 👉 Email Gaia: rupress.org/jem/pages/ed... Read our new collection on the topic: 👉 rupress.org/jem/collecti...

Thrilled to see one of my images featured on the cover! 🔬

Journal of Experimental Medicine@jem.org · 2w ago

Our September cover (rupress.org/jem/issue/22... ) depicts a confocal image of Ramos B cells extracting surface-bound antigen from plasma membrane sheets. Sheets are labeled w/ fluorescent surrogate antigen (magenta); B cells are marked by CD19 (orange). See Berzosa et al. doi.org/10.1084/jem....

Targeting Mettl8-Tcf1 axis promotes CD8⁺ TPEX differentiation and antitumor immunity. From Jiaxi Song, Dan Cui, Qizhao Huang, Jia Li, Fengyin Li, and colleagues: rupress.org/jem/article/... Part of our #CancerImmunotherapy 2026 👉 rupress.org/jem/collecti... #CSHAsia

Tumor-reactive LAG3⁺CD8⁺ T cells diverge into terminally exhausted cells and long-lived memory T cells. From Vaishali Aggarwal, Yangxi Sun, Chang Liu, Dario Vignali @vignalilab.bsky.social: rupress.org/jem/article/... Part of our #CancerImmunotherapy 2026 👉 rupress.org/jem/collecti... #CSHAsia

Functional heterogeneity and plasticity in naïve #CD8 #Tcells drive superior effector and memory responses. New study from Yamato Sajiki, Koichi Araki and colleagues @cincyresearch.bsky.social: rupress.org/jem/article/... #LymphocyteBiology #InfectiousDisease #HostDefense

Our September cover (rupress.org/jem/issue/22... ) depicts a confocal image of Ramos B cells extracting surface-bound antigen from plasma membrane sheets. Sheets are labeled w/ fluorescent surrogate antigen (magenta); B cells are marked by CD19 (orange). See Berzosa et al. doi.org/10.1084/jem....

PRECISE-seq reveals disease-relevant TCR repertoires with phenotypic plasticity. From Shibo Liu, Guanghao Liang, Yayun Yang, Yanyang Shi, Lihui Dong, Peng R. Chen, Meng Michelle Xu et al.: rupress.org/jem/article/... Part of our #CancerImmunotherapy 2026 👉 rupress.org/jem/collecti... #CSHAsia

In this review, Almonte, Thomas, and Zitvogel highlight how the gut #microbiome modulates immune checkpoint blockade efficacy in #cancer. rupress.org/jem/article/... Part of our #CancerImmunotherapy 2026 👉 rupress.org/jem/collecti... #CSHAsia