Interested in working on clinical, genetic and neuroimaging data in a preclinical #Alzheimers population? Check out our immensely phenotyped, openly accessible dataset! Access instructions here: amypad.eu/data/ And our recent publication describing everything MRI: doi.org/10.1038/s415...

Please find our latest publication in Alzheimer's & Dementia: doi.org/10.1002/alz.... We find cortical gray-white matter tissue contrast to be a particularly early emerging MRI marker of Alzheimer's pathology, using the preclinical @imi-amypad.bsky.social Prognostic & Natural History Study!

Cortical gray–white matter contrast alterations precede amyloid‐β positivity and macrostructural changes in older adults without dementia

INTRODUCTION Early Alzheimer's disease (AD) involves subtle cortical changes that may precede atrophy. Magnetic resonance imaging (MRI) microstructural markers may detect earlier pathology than clas...

doi.org

📢 NEW paper out in Alzheimer's & Dementia, using data from the AMYPAD Prognostic and Natural History Study! Congratulations to all authors 👏 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Cortical thickness subtypes in cognitively unimpaired individuals: Differential network and transcriptomic vulnerability to cortical thinning

INTRODUCTION The emergence, stability, and contributing factors of Alzheimer's disease (AD) gray matter subtypes remain unclear. METHODS We analyzed data from 1323 individuals without a diagnosis ...

alz-journals.onlinelibrary.wiley.com

📣New paper out on the role of cerebral amyloid-β in cortical, allocortical and subcortical atrophy in (mostly) cognitively unimpaired individuals from the AMYPAD Prognostic and Natural History Study! Congratulations to all authors👏 www.sciencedirect.com/science/arti...

Amyloid PET predicts atrophy in older adults without dementia: Results from the AMYPAD Prognostic & Natural History study

The impact of amyloid-β (Aβ) accumulation on regional brain atrophy in preclinical Alzheimer’s disease (AD), and its interaction with risk factors lik…

sciencedirect.com

1 To predict the behaviour of a primate, would you rather base your guess on a closely related species or one with a similar brain shape? We looked at brains & behaviours of 70 species, you’ll be surprised! 🧵Thread on our new preprint with @r3rt0.bsky.social , doi.org/10.1101/2025...

So excited and honored to be invited to present the opening plenary at #AIC2025 this year in Toronto! 🧠 🙏 I would be very grateful if you could help me gather the most inspiring papers (including your own!) of the past year by completing this ~5min survey: alz.surveymonkey.com/r/923BTQK

Anika Wuestefeld, PhD@anikawuestefeld.bsky.social · last yr.

🚨Calling all neuroimagers! Help @emmacoomans.bsky.social shape the opening plenary at #AIC2025 (Toronto, July 26th) "Accomplishments of the Past Year" and share the most impactful neuroimaging research from the past year via this brief survey (~5min) by May 30th. act.alz.org/site/R?i=eOe...