Great work @marcus-ruscetti.bsky.social

Marcus Ruscetti Lab@marcus-ruscetti.bsky.social · last yr.

Our study contributes a more generalizable approach to stabilize STING and increase immunogenicity in cold tumors where STING expression is silenced through targeting PPT1. We believe this could open the door for rationale combinations with STING agonists and ICB therapies.

In my first bsky post, I am excited to share our recent review out in @natrevimmunol.bsky.social. We discuss mechanisms that identify patterns of pathogenesis -- specific ligands or symptoms in the host that indicate active infection with an infectious microorganism. www.nature.com/articles/s41...

Patterns of pathogenesis in innate immunity: insights from C. elegans - Nature Reviews Immunology

In this Review, Tse-Kang, Wani and Pukkila-Worley discuss how nematodes, such as Caenorhabditis elegans, rely on ‘patterns of pathogenesis’ as opposed to the sensing of specific ligands by pattern-rec...

nature.com

The plan for NIH is in, source with full 64 page proposal for all of HHS is linked. Reported in WaPo. This is catastrophic. Reduction to 8 centers. 40% cut in budget. 15% IDC cap. This will decimate science across America open.substack.com/pub/insideme...