Ashwagandha reduced stress-related #anxiety with a big effect in this large, placebo-controlled trial of 226: psych-partners.com/ashwagandha-... Caveats: Industry funded, liver/thyroid risks #psychiatry #pmhnp #therapy
Chris Aiken, MD
@chrisaikenmd.bsky.social
Editor, Carlat Psychiatry Report. Assist Prof, NYU & WFU medical schools. www.chrisaikenmd.com Posting daily updates on all things psychiatric
First, call it functional neurologic disorder. More tips on how to discuss this controversial cause of unexplained neurologic symptoms in a review from Johns Hopkins #neurology, including online resources for patients: psych-partners.com/how-to-expla... #psychiatric #pmhnp #therapy
Aripiprazole or bupropion for antidepressant augmentation? Similar in new trial of anxious #depression. Learn why bupropion causes less anxiety than often thought: psych-partners.com/aripiprazole... #psychiatry #pmhnp
New study reveals early signs of #bipolar mania not captured in DSM, including: ▪ Anxiety ▪ Suspiciousness ▪ Taking song lyrics personally ▪ Distorted sense of time ▪ Sensitivity to colors and sounds ▪ Forgetfulness Full list: psych-partners.com/early-signs-... #psychiatry #pmhnp
Novel antipsychotic: ▪ Possible benefits beyond psychotic symptoms in #schizophrenia ▪ Better tolerated on empty stomach ▪ Screen for urinary retention, narrow-angle glaucoma, and liver disease More: psych-partners.com/cobenfy-xano... #psychiatry #pmhnp
Learn 15 ways to use a light box in my webinar on Light and Dark #Therapy: psych-partners.com/webinar-ligh... Includes a 24/7 circadian plan for #bipolar and #depression. #psychiatry #pmhnp
New guidelines on shift work disorder emphasize ▪ Light/dark #therapy ▪ Melatonin, suvorexant ▪ Modafinils ▪ #Sleep scheduling Full details: psych-partners.com/practice-gui... #psychiatry #pmhnp #neurology
Here are the new industry-sponsored trials presented at the 2026 APA meeting: psych-partners.com/new-medicati... ▪ Centanafadine for #ADHD ▪ New form of amisulpride for #schizophrenia ▪ Auvelity in #dementia #psychiatry #pmhnp
Cariprazine joins aripiprazole and risperidone as options for irritability in #autism with this new industry-sponsored trial. However, I recommend other options first line: psych-partners.com/cariprazine-... #psychiatry #pmhnp
What I learned writing the CAM #Psychiatry Fact Book: ▪ ALC has a niche in chronic depression/trauma ▪ B6 relieves antipsychotic side effects ▪ Adaptogens relieve stress & improve functioning ▪ And some herbs are best left in the ground Excerpts at: psych-partners.com/sample-the-c...
New study proposes "Circadian Subtype" in 1 in 4 with #depression: psych-partners.com/a-circadian-... Whether it's valid, time will tell. Suggestion is night owls, fatigue, and winter depression point to poorer SSRI response and risks for bipolar, ADHD, and worse metabolic health. #psychiatry
Every half hour of screen time after 10 PM costs a teen about 13 minutes of sleep, concludes one of the best designed trials on this to date: psych-partners.com/screens-and-... Sleep loss = #ADHD, #depression, impulsivity, suicide, traffic accidents #psychiatry #pmhnp #therapy
Saffron for #ADHD? This is the fifth clinical trial, but all are small and flawed, so I'm asking: What's been your experience? psych-partners.com/saffron-for-... #psychiatry #naturalhealth #pmhnp
This is a rarity: A year long placebo-controlled trial. And while it concludes that risperidone is effective for aggression in childhood #ADHD, I'm not sure it's the best option. Find out why: psych-partners.com/risperidone-... #psychiatry #pmhnp
TikTok suggests there's something wrong with us, usually #ADHD or #Autism, even when we don't ask, concludes this new investigation into the algorithm: psych-partners.com/how-dr-tikto... #psychiatry #pmhnp #therapy
1. Even mild ADHD has a meaningful effect on mortality: psych-partners.com/mild-adhd-ca... 2. Watch for diagnostic conversion: children with #ADHD have 9-fold higher risk of developing #bipolar and 5-fold of psychosis: psych-partners.com/adhd-raises-... #psychiatry #pmhnp #therapy
Medications fail to augment ketamine in #depression. But psychotherapy holds promise, concludes new review: psych-partners.com/what-augment... #psychiatry #pmhnp #therapy
Deep brain stimulation is powerful for #depression, but requires surgery. Is there a non-invasive way to activate the same area? This well-designed study did, with high response rates. Learn about temporal interference stimulation: psych-partners.com/a-new-type-o... #psychiatry #tms #pmhnp
Caffeine impairs sleep quality, even when it doesn't cause insomnia, concludes new review: psych-partners.com/how-caffeine... #nutrition #psychiatry #pmhnp #therapy
#Therapy is first-line for compulsive sexuality, with SSRIs and naltrexone as possible medications. This randomized trial compares them head-to-head, with similar outcomes, but personal factors decide between them: psych-partners.com/ssri-vs-nalt... #psychiatry #pmhnp #sexualhealth
A handful of nuts a day is a simple way to improve #mentalhealth. Walnuts worked in a new randomized trial, joining about a dozen similar trials testing everything from almonds to pistachios: psych-partners.com/walnuts-impr... Limitation: Unblinded #psychiatry #pmhnp #nutrition #therapy
1. The self-medication hypothesis comes up short: psych-partners.com/self-medicat... 2. Hitting rock bottom is not a reliable route to recovery: psych-partners.com/dont-wait-fo... #psychiatry #addiction #sobriety #pmhnp #therapy
Longer delay in starting lithium = lower response in this 25 yr uncontrolled study of bipolar: ▪ Under 3 yr delay: 69% ▪ 3-8 yr: 50% ▪ 8-17 yr: 44% ▪ Over 17 yr: 40% Learn how to recognize #bipolar and use #lithium early psych-partners.com/start-lithiu... #psychiatry #pmhnp
Clomiparmine is a standard treatment for premature ejaculation, and this large trial tested it with sildenafil (Viagra). The two worked better than either alone: psych-partners.com/clomipramine... Trial is industry sponsored, aiming for approval of a combo pill. #psychiatry #sexualhealth #therapy
Even in psychotic mania, mood stabilizers have better long-term outcomes than antipsychotics, concludes new study designed to mimic a randomized trial. Learn the caveats, and which antipsychotics may differ: psych-partners.com/you-dont-nee... #psychiatry #pmhnp #bipolar #bipolardisorder
The AMA journal changed course in new paper recommending e-cigs for nicotine cessation. They have toxins, but they help quit and are much safer than smoking. Learn how to use them and find FDA-cleared products: psych-partners.com/jama-changes... #stopsmoking #medicine #psychiatry #pmhnp #therapy
Here's a first... benzodiazepine prescriptions declined in the past decade. Lower rates among all clinicians except one group - that I suspect is due to workforce shifts: psych-partners.com/benzodiazepi... #psychiatry #pmhnp #medicine
These don't clarify whether cognitive symptoms are due to adult #ADHD: ▪ Stimulant response ▪ Rating scales ▪ Adult onset without childhood precedent Learn how to make the diagnosis in this new review: psych-partners.com/what-else-co... #psychiatry #pmhnp #therapy
Key points from new analyses: ▪ Methylphenidate is not addictive when used for ADHD ▪ XR versions are less rewarding ▪ Tolerance develops to rewarding, energizing qualities, not to #ADHD benefits #psychiatry #pmhnp #mentalhealth #therapy
#Bipolar disorder usually starts in the teens, but it can also start during menopause, concludes new analysis. Learn how menopause changes mood: psych-partners.com/perimenopaus... #psychiatry #pmhnp