Our paper in Nature Comms is now online! Summary below but in short we use living human brain slice cultures in a number of different ways to model dementia processes. Big team effort led by myself, @robertmcgeachan.bsky.social and @clairedurrant1.bsky.social rdcu.be/ej647

Divergent actions of physiological and pathological amyloid-β on synapses in live human brain slice cultures

Nature Communications - Understanding synapse loss in Alzheimer’s disease has been hampered by a lack of human model systems. Here, the authors show that manipulation of physiological or...

rdcu.be

Delighted to share our paper examining synaptic tau in PSP. Many thanks to @robertmcgeachan.bsky.social @clairedurrant1.bsky.social and our many collaborators and funders. And extra special thanks to tissue donors who make this work possible.

Edinburgh Neuroscience@edinunineuro.bsky.social · last yr.

📢Fabulous new paper from @tspiresjones.bsky.social, @clairedurrant1.bsky.social & team describes new mechanisms in Progressive Supranuclear Palsy, suggesting that targeting tau in synapses is a promising approach for future treatments. Full paper➡️www.nature.com/articles/s41593-025-01992-5 🧠

Fantastic to see this work from @clairedurrant1.bsky.social group out in print! Important results using living human brain tissue to study Alzheimer’s disease www.nature.com/articles/s41...

Divergent actions of physiological and pathological amyloid-β on synapses in live human brain slice cultures - Nature Communications

Understanding synapse loss in Alzheimer’s disease has been hampered by a lack of human model systems. Here, the authors show that manipulation of physiological or pathological Aβ has differing effects...

nature.com

Amazing to welcome HRH The Duchess of Edinburgh, Patron of Race Against Dementia to our lab! An incredible opportunity to showcase our work with living human brain slice cultures and the importance of investing in dementia research. We are very lucky to have her support.

@clairedurrant1.bsky.social @tspiresjones.bsky.social

Signing off for Christmas after a great December. Grateful for the good stuff.

In case anyone on BlueSky hasn't seen it, this may be the funniest scientific study ever published. Bringing it up now as the amazing @scotsfriction.bsky.social has just issued a "teaspoon amnesty" for our common room www.bmj.com/content/331/...

🧠 130 people now in this UK Dementia Starter Pack! 🧠 📈 (50 more than 2 days ago!) 📈 A great mix of Profs/PIs/Post-docs/PhDs/Technicians. Please re-post so it can reach a wider audience as I'm sure there are more of us out there ☺️🦋 go.bsky.app/S6FfsTp

Got the BEST email over the weekend about provisional paper acceptance and still smiling and doing paper accepted dance. So a heads up that in the not too distant future this amazing data will have a "forever" peer-reviewed home: www.medrxiv.org/content/10.1...

snoopy is dancing on a green background with the words happy dance below him

ALT: snoopy is dancing on a green background with the words happy dance below him

media.tenor.com

Hi Blue Sky folks 😃 We bring together the diverse community of brain & mind researchers across the Uni of Edinburgh to promote interdisciplinary collaboration & positive research culture🧠 Follow us for ➡️Research highlights 🤝News from our community 🌎Events & opportunities #neuroscience #neuroskyence