Before susceptibility results, can AI flag carbapenem-resistant A. baumannii? An ICU-based XGBoost model achieved AUC 0.878. www.sciencedirect.com/science/arti... @isacworld.bsky.social
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Cefiderocol resistance before its clinical use in China? Among 443 carbapenem-resistant E. coli isolates, 23% were resistant, with ST167 and FhuA P50S implicated. www.sciencedirect.com/science/arti... @isacworld.bsky.social
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How does hypervirulent K. pneumoniae worsen liver abscess? Hcp triggers macrophage HMGB1 release and RAGE-dependent endothelial pyroptosis. www.sciencedirect.com/science/arti... @isacworld.bsky.social
The T6SS effector Hcp of hypervirulent Klebsiella pneumoniae exacerbates liver abscess by inducing macrophage-HMGB1/RAGE-dependent endothelial pyroptosis
Hypervirulent Klebsiella pneumoniae (hvKP) causes pyogenic liver abscess and fulminant sepsis via vascular endothelial dysfunction and injury. This st…
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A peptide that helps restore antibiotic activity? FIRL perturbs BamA–BamD coupling, boosting polymyxin B in preclinical infection models. www.sciencedirect.com/science/arti... @isacworld.bsky.social
FIRL potentiates antibiotic activity against multidrug-resistant Gram-negative bacteria: Selective BamA–BamD interface perturbation induces functional outer membrane vulnerability
The outer membrane (OM) of Gram-negative bacteria limits antibiotic entry and contributes substantially to multidrug resistance. OM integrity depends …
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Triple carbapenemase-producing K. pneumoniae ST6668 resistant to novel β-lactam/β-lactamase inhibitor combinations and cefiderocol emerges in Italy. A warning for AMR surveillance! www.sciencedirect.com/science/arti... @isacworld.bsky.social
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🧠🦠 Let's make AI our friend! From predicting antimicrobial resistance and infections to supporting antibiotic stewardship and accelerating AI-driven drug discovery 📚 Explore recent advances: www.sciencedirect.com/special-issu... #AI #AMR @isacworld.bsky.social
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🙌 A big thank you to our amazing reviewers! As we reflect on Peer Review Week last week, we want to recognise the time and expertise you contribute to strengthening scientific research. 🔬 #PeerReviewWeek #Research @isacworld.bsky.social
🔥Check out the Hot Topic: www.sciencedirect.com/science/arti... Growing interest in phage therapy but important knowledge gaps and barriers remain...🦠 #PhageTherapy #AMR @isacworld.bsky.social
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⭐ Editor's Choice 🚨 The growing accumulation of antibiotic resistance is a serious concern! New research finds ST1545 Klebsiella pneumoniae carrying genes that make them resistant to important antibiotics - carbapenems and tigecycline www.sciencedirect.com/science/arti... @isacworld.bsky.social
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📔New issue is out! Featuring the latest research on phage therapy, novel antimicrobials, diagnostics & resistance mechanisms! Explore more: www.sciencedirect.com/journal/inte... @isacworld.bsky.social
International Journal of Antimicrobial Agents | Vol 67, Issue 9, September 2026 | ScienceDirect.com by Elsevier
Read the latest articles of International Journal of Antimicrobial Agents at ScienceDirect.com, Elsevier’s leading platform of peer-reviewed scholarly literature
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🌟A fitting tribute to Professor Alasdair Macintosh Geddes—a pioneering infectious diseases physician and outstanding mentor www.sciencedirect.com/science/arti... @isacworld.bsky.social
Professor Alasdair Macintosh Geddes: A life of science, service, and kindness
All content on this site: Copyright © 2026 Elsevier B.V., its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.
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🔥 Hot Topic New antibiotics offer hope but are they reaching the patients who need them? Access to newly approved antibacterials across Asian countries remains limited, with substantial approval delays www.sciencedirect.com/science/arti... #Antibiotics #InfectiousDiseases @isacworld.bsky.social
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📢 New Issue | IJAA Volume 67, Issue 8 The latest issue is now online! Featuring: 🔹 Reviews on antifungal prophylaxis and fluoroquinolone prophylaxis 🔹 Insights into novel therapeutics and machine learning Explore more: www.sciencedirect.com/journal/inte... @isacworld.bsky.social
International Journal of Antimicrobial Agents | Vol 67, Issue 8, August 2026 | ScienceDirect.com by Elsevier
Read the latest articles of International Journal of Antimicrobial Agents at ScienceDirect.com, Elsevier’s leading platform of peer-reviewed scholarly literature
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🥳We're proud to share that the International Journal of Antimicrobial Agents has achieved a 2025 Impact Factor of 5.0, up from 4.6 in 2024. A sincere thank you to our authors, reviewers, editors and readers! @isacworld.bsky.social
New study: Stepwise cefiderocol exposure in NDM-producing Klebsiella pneumoniae selected recurrent baeS variants and reshaped iron uptake, porin expression, blaNDM-5, and biofilm responses. www.sciencedirect.com/science/arti... @isacworld.bsky.social
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New IJAA study tracks in vivo tigecycline resistance in ST540 CRAB, revealing adeS N125S-driven AdeABC upregulation, collateral sensitivity to cefoperazone/sulbactam, and ICU transmission. www.sciencedirect.com/science/arti... @isacworld.bsky.social
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MALDI-TOF MS combined with machine learning accurately predicts ceftriaxone resistance in Salmonella (ROC-AUC up to 0.924). This interpretable, web-based approach could accelerate targeted therapy and strengthen antimicrobial stewardship. www.sciencedirect.com/science/arti... @isacworld.bsky.social
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New in IJAA (Vol.67, Issue 7): AI-guided AMR prediction, emerging CZA–cefiderocol cross-resistance, phage therapy advances, polymyxin B PK, and cefiderocol clinical evidence. www.sciencedirect.com/journal/inte... @isacworld.bsky.social
International Journal of Antimicrobial Agents | Vol 67, Issue 7, July 2026 | ScienceDirect.com by Elsevier
Read the latest articles of International Journal of Antimicrobial Agents at ScienceDirect.com, Elsevier’s leading platform of peer-reviewed scholarly literature
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Using 5,239 Klebsiella pneumoniae genomes, a machine learning model accurately predicted multi-level antimicrobial resistance for 11 antibiotics (mean AUC >0.9), advancing precision therapy and AMR control. www.sciencedirect.com/science/arti... @isacworld.bsky.social
Machine learning-based prediction of multi-level anti-microbial resistance in Klebsiella pneumoniae using whole-genome sequencing data
In this study, we developed an integrated approach for accurate and comprehensive prediction of anti-microbial resistance (AMR) using whole-genome seq…
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IJAA Volume 67 Issue 6 features the latest advances in AMR, AI-guided infection prediction, CRKP resistance, phage therapy, anti-biofilm strategies, and antimicrobial PK/PD optimization. www.sciencedirect.com/journal/inte... @isacworld.bsky.social
International Journal of Antimicrobial Agents | Vol 67, Issue 6, June 2026 | ScienceDirect.com by Elsevier
Read the latest articles of International Journal of Antimicrobial Agents at ScienceDirect.com, Elsevier’s leading platform of peer-reviewed scholarly literature
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Repurposing sulfamethoxazole through gold nanocluster modification: SMZ_Au NCs showed potent antibacterial and anti-biofilm activity against MDR Gram-negative bacteria, with promising in vivo efficacy and safety. www.sciencedirect.com/science/arti... @isacworld.bsky.social
Repurposing sulfamethoxazole via gold nanocluster modification for antibacterial and anti-biofilm activity against multidrug-resistant Gram-negative bacteria
The global spread of antimicrobial resistance represents a severe threat to public health, with infections caused by multidrug-resistant Gram-negative…
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AI + MALDI-TOF MS rapidly predicted antimicrobial resistance in Acinetobacter baumannii infection with >83% accuracy, supporting faster AI-assisted AST in clinical practice. www.sciencedirect.com/science/arti... @isacworld.bsky.social
Development and validation of a predictive model for profiling antibiotic resistance phenotypes of Acinetobacter baumannii strains via clinical MALDI-TOF mass spectra: A multicenter study
Acinetobacter baumannii is a significant pathogen responsible for healthcare-acquired infections (HAIs), posing challenges due to its rising resistanc…
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IJAA Volume 67, Issue 5 is now online, featuring advances in phage therapy, AMR prediction, resistance mechanisms, PK/PD, and antimicrobial stewardship. Explore the latest updates in infectious diseases research. www.sciencedirect.com/journal/inte... @isacworld.bsky.social
International Journal of Antimicrobial Agents | Vol 67, Issue 5, May 2026 | ScienceDirect.com by Elsevier
Read the latest articles of International Journal of Antimicrobial Agents at ScienceDirect.com, Elsevier’s leading platform of peer-reviewed scholarly literature
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SMART ML model predicts postoperative infection risk (AUC 0.86), enabling targeted prevention and antimicrobial stewardship. www.sciencedirect.com/science/arti... @isacworld.bsky.social
Surgical MAchine learning model for predicting Risk of postoperative infecTions in general elective surgery (SMART): A modelling study
To apply a machine learning (ML) model that we developed and internally validated for predicting postoperative infection likelihood after elective gen…
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China hospital antibiotic use fell (46.8→35.3 DDDs/100 PDs, 2013–2024), but shifts to Watch/Reserve raise AMR risks. By 2030, use may drop 11.4%, highlighting need for targeted stewardship. www.sciencedirect.com/science/arti... @isacworld.bsky.social
Present trajectories to forecasted future: A longitudinal analysis of hospital antibiotic use in China from 2013 to 2024 and projections to 2030
To characterize the decadal trends in antibiotic use among hospitalized patients in China, and to project consumption trajectories through 2030.We ana…
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Phage–colistin synergy depends on order: phage-first enhances killing, colistin-first weakens phage. Only simultaneous use suppresses resistance in MDR A. baumannii. www.sciencedirect.com/science/arti... @isacworld.bsky.social
Treatment sequences of a phage and colistin combination trigger different evolution pathways of a multidrug-resistant Acinetobacter baumannii yielding distinct treatment outcomes
To better understand the underlying mechanisms of treatment order of phage and antibiotic synergy (PAS), particularly in the context of planktonic bac…
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Cefiderocol resistance emerging in China: blaNDM-carrying E. coli shows high resistance via CirA/PBP3 mutations, with clonal spread risk. Urgent need for One Health surveillance. www.sciencedirect.com/science/arti... @isacworld.bsky.social
Molecular mechanisms and clonal distribution of cefiderocol-resistant blaNDM-carrying Escherichia coli: A multi-centre study in China
Reports on cefiderocol resistance are increasing globally despite its unavailability in China. The blaNDM-carrying Escherichia coli was one of the mos…
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Imagine viruses that fight bacteria instead of causing disease—phages are doing just that! From hospitals to farms to crops, One Health approach is turning phage therapy into a real-world weapon against AMR. www.sciencedirect.com/science/arti... #PhageTherapy #OneHealth @isacworld.bsky.social
Phage therapy in China: Arming the One Health approach
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Can phages, probiotic strains & host‑directed therapies reshape our fight against AMR? 🦠 👀 Check them out in the latest research: www.sciencedirect.com/journal/inte... #AMR #InfectiousDiseases #PhageTherapy #Antimicrobials #HostDirectedTherapy @isacworld.bsky.social
International Journal of Antimicrobial Agents | Vol 67, Issue 3, March 2026 | ScienceDirect.com by Elsevier
Read the latest articles of International Journal of Antimicrobial Agents at ScienceDirect.com, Elsevier’s leading platform of peer-reviewed scholarly literature
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🚨 Hot Topic Artificial intelligence and machine learning are transforming antimicrobial research—accelerating drug discovery, improving resistance prediction and enabling precision therapy to outpace superbugs. www.sciencedirect.com/science/arti... #AMR #AI #machinelearning @isacworld.bsky.social
Artificial intelligence and machine learning in antimicrobial discovery, resistance prediction, and precision therapy
The global crisis of antimicrobial resistance (AMR) demands a paradigm shift in traditional drug discovery, and artificial intelligence (AI) is unique…
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