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PLOS Biology

@plosbiology.org

A leading life science journal that champions inclusive, high-impact research across all disciplines—from molecules to ecosystems. We offer innovative formats and collaborative editorial support to ensure your work achieves its full scientific impact.

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Johanna Rimmele@johannarimmele.bsky.social · yesterday

We had a look at a question I am really excited about: does an individuals intrinsic brain rhythm predict speech tracking and comprehension? And how do speech motor and auditory rhythms work together? by Christina Lubinus, @annekeitel.bsky.social @jonasobleser.bsky.social @davidpoeppel.bsky.social

PLOS Biology@plosbiology.org · yesterday

Speech comprehension is thought to depend on #auditory - #motor interactions via brain rhythms. This study by @johannarimmele.bsky.social &co links theta and motor rhythms to stronger #speech tracking, the latter among those with high auditory-motor synchronization. 🧪 #AcademicSky plos.io/4fDnKY0

Individuals recruit brain rhythms for speech processing through different processing routes. Conceptual illustration of the involvement of intrinsic brain rhythms in speech processing. The image symbolizes our finding that only individuals with high auditory-motor synchronization behavior recruit intrinsic brain rhythms of speech motor brain areas for speech processing. The Image was created by Felix Bernoully under the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/).
James Orr@jamesaorr.bsky.social · 4d ago

One of ecology’s oldest questions - how does population growth change as density increases? - remains surprisingly contentious. In our new @plosbiology.org paper we contribute to the ongoing debate by applying the idea of “Growth-Density Inversion”: doi.org/10.1371/jour.... 1/6

Growth-density inversion in Escherichia coli reveals superlinear, not sublinear, density dependence

Sublinear density dependence has been widely reported empirically, but this is at odds with resource competition theory. This study uses a tightly controlled test in a microbial model system to reveal...

doi.org

Matthew Hahn@3rdreviewer.bsky.social · 5d ago

Very cool pair of papers demonstrating little link between amount of additive genetic variation and amount of nucleotide variation within species: journals.plos.org/plosbiology/... www.pnas.org/doi/10.1073/...

Levels of additive genetic variation vary substantially between species

Adaptive potential determines how populations respond to environmental change. This study compiles evolvability estimates from over 170 multicellular species, revealing substantial variation across th...

journals.plos.org

Gordon Hodson@gordonhodsonphd.bsky.social · 7d ago

#AcademicSky #PsychSciSky #OpenScience In survey of Swiss animal researchers, of those who responded, only 10% had used pre-registation. And 39% had NEVER HEARD of pre-registration!! journals.plos.org/plosbiology/...

A survey of researchers’ attitudes to preregistration in animal research reveals multiple perceived barriers to adoption

Preregistration is a promising and potentially impactful Open Science practice, but remains uncommon in animal research. This survey of animal researchers’ experiences, attitudes and barriers toward p...

journals.plos.org

PLOS Biology@plosbiology.org · last wk.

#Preregistration supports #OpenScience, but is uncommon in animal research. This Meta-Research study by @hannowuerbel.bsky.social reveals that despite known benefits, perceived bureaucracy, time costs and inflexibility hinder adoption. 🧪#AcademicSky @unibe.ch @swissrn.bsky.social plos.io/4pL0tXq

Two graphs the worries of participants about preregistration from those who never preregistered, as well as the problems encountered by those who did preregister. Worries were more prevalent than actual problems, although both graphs show highlight the prevalence of responses related to high time costs and bureaucratic burden.
PLOS Biology@plosbiology.org · last wk.

The human G6P transporter (SLC37A4) moves glucose-6-phosphate into the endoplasmic reticulum, supporting blood glucose stability and metabolism. This study solves the #structure of SLC37A4 in 3 conformations, providing insights substrate recognition & inhibition. 🧪#AcademicSky plos.io/4wo87tf

Conformational transitions and mechanistic model of substrate transport and inhibition. Top: Structural models of SLC37A4 in inward-open (left) and outward-open (right) conformations viewed in the membrane plane. The N-terminal domain (NTD) and C-terminal domain (CTD) are shown as yellow and cyan cartoons, respectively; horizontal black lines indicate the approximate membrane boundaries. The cluster of basic residues in the NTD (K29, R28 and K64) and K240 in the CTD are shown as green sticks. The putative translocation pathway is depicted as a transparent surface. In the inward-open state, G6P (red sticks) binds from the cytosolic side to the NTD basic cluster, while K240 in the CTD faces the cytosolic side. In the outward-open state, reorientation of the NTD and CTD exposes the binding site to the lumen, allowing G6P release and Pi binding, as indicated by arrows. Bottom: The schematic illustrates the conformational transitions between the inward-open, occluded, and outward-open states. The inhibition scenario (top) shows the binding of CHA to the inward-open state, which sterically hinders the transition to the occluded state (indicated by the red cross), thereby locking the transporter. In contrast, the functional antiport cycle (bottom) depicts the exchange of substrates: G6P binds to the inward-open state, facilitating the transition to the occluded state. Subsequently, the transporter shifts to the outward-open conformation to release G6P and accommodate the binding of inorganic phosphate (Pi) for transport in the reverse direction. Key residues (R28, K29, K64 on TM 1/2 and K240 on TM 7) involved in substrate/inhibitor recognition are highlighted.
Alex Holcombe@alexh.bsky.social · last wk.

We looked at all 255 articles of animal models of opiod addiction in leading journals 2019 to 2023. Zero preregistered, and zero shared their analysis code. onlinelibrary.wiley.com/doi/full/10....

How Transparent and Reproducible Are Studies That Use Animal Models of Opioid Addiction?

This study assessed transparency, reproducibility and bias minimization practices in animal models of opioid addiction research from 2019 to 2023. Key indices included analysis script sharing, prereg...

onlinelibrary.wiley.com

PLOS Biology@plosbiology.org · last wk.

The human G6P transporter (SLC37A4) moves glucose-6-phosphate into the endoplasmic reticulum, supporting blood glucose stability and metabolism. This study solves the #structure of SLC37A4 in 3 conformations, providing insights substrate recognition & inhibition. 🧪#AcademicSky plos.io/4wo87tf

Conformational transitions and mechanistic model of substrate transport and inhibition. Top: Structural models of SLC37A4 in inward-open (left) and outward-open (right) conformations viewed in the membrane plane. The N-terminal domain (NTD) and C-terminal domain (CTD) are shown as yellow and cyan cartoons, respectively; horizontal black lines indicate the approximate membrane boundaries. The cluster of basic residues in the NTD (K29, R28 and K64) and K240 in the CTD are shown as green sticks. The putative translocation pathway is depicted as a transparent surface. In the inward-open state, G6P (red sticks) binds from the cytosolic side to the NTD basic cluster, while K240 in the CTD faces the cytosolic side. In the outward-open state, reorientation of the NTD and CTD exposes the binding site to the lumen, allowing G6P release and Pi binding, as indicated by arrows. Bottom: The schematic illustrates the conformational transitions between the inward-open, occluded, and outward-open states. The inhibition scenario (top) shows the binding of CHA to the inward-open state, which sterically hinders the transition to the occluded state (indicated by the red cross), thereby locking the transporter. In contrast, the functional antiport cycle (bottom) depicts the exchange of substrates: G6P binds to the inward-open state, facilitating the transition to the occluded state. Subsequently, the transporter shifts to the outward-open conformation to release G6P and accommodate the binding of inorganic phosphate (Pi) for transport in the reverse direction. Key residues (R28, K29, K64 on TM 1/2 and K240 on TM 7) involved in substrate/inhibitor recognition are highlighted.