github.com/XiaoxuYangLab/DeepMosaic/releases/tag/v1.2.0 DeepMosaic v1.2.0 is now released. It enables custom genome build for donor-specific genome or non-human diploid organism. Additional changes and updates are documented in the release note. Many thanks to Sai and our user community!

Congratulations to @xiaoxuyang.bsky.social @uuhsresearch.bsky.social on his team's seminal discovery in collaboration with colleagues @ucsdhealthsci.bsky.social and published in @nature.com! How Early Nerve Cell Choices Shape the Peripheral Nervous System healthcare.utah.edu/newsroom/new...

Unlocking Secrets of Human Development: How Early Nerve Cell Choices Shape the Peripheral Nervous System

By examining genetic clues that linger in adult cells, scientists have now gained surprising insights into the developmental origins of the nerves outside the brain and spine.

healthcare.utah.edu

Unlocking Secrets of Human Development: How Early Nerve Cell Choices Shape the Peripheral Nervous System healthcare.utah.edu/newsroom/new...

Unlocking Secrets of Human Development: How Early Nerve Cell Choices Shape the Peripheral Nervous System

By examining genetic clues that linger in adult cells, scientists have now gained surprising insights into the developmental origins of the nerves outside the brain and spine.

healthcare.utah.edu

Nature research paper: Developmental organization of sensory and sympathetic ganglia go.nature.com/3Qdz2HP

Developmental organization of sensory and sympathetic ganglia - Nature

Findings suggest that neural crest fate bias predominantly emerges within the neural tube, and that only a minor subset of delaminated progenitors retain multipotency to generate both sensory and sympathetic derivatives.

go.nature.com

In a study published today in Nature (rdcu.be/fbf5Q), we described the developmental organization of sensory and sympathetic ganglia in multiple organisms. Huge thanks to the great contribution from @gleesonlab.bsky.social , Keng Ioi (Harry) Vong, @melaniedwhite.bsky.social, and all collaborators!

Perhaps the most puzzling part: We see a paradox: the rsRNA length shift is progressive⏳yet the global RNA profile shows an "Aging Cliff"📉. Cliff or Progression? Maybe the gradual shift is the forerunner—accumulating silently until it triggers the cliff. bsky.app/profile/qich...

Qi Chen@qichen-lab.bsky.social · 8mo ago

1/5 It took us some time to connect the dots...now in @embojournal.org we use PANDORA-seq to start decoding the 'sperm RNA code of aging' We find a conserved rsRNA length shift that reflects aging in both mouse & human sperm, and an 'aging cliff' at mid-life🧵 link.springer.com/article/10.1...

Our special issue "Genomic Mosaicism in Human Development and Diseases" on Genes www.mdpi.com/2073-4425/16... is officially out! Thank you all authors for your contributions! Thanks, Xincen, for writing the editorial with me.

Welcome, Mitchell!

Mitchell R. Vollger@mrvollger.bsky.social · last yr.

Very excited to share I’ll be starting my own group at University of Utah in the Department of Human Genetics in the new year! Reach out if you are interested! vollgerlab.com

High-resolution dissection of human cell type-specific enhancers in cis and trans activities (sciencedirect.com/science/arti...) a long journey form @wang__meng and Dr. Wu, glad to be part of this!