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New JCS snapshot - A ULK1–MTFR1L feedback loop links mitochondrial fission, mitophagy and apoptosis @riccardobabic.bsky.social, Leon Lucya & Christoph Reiter present the key findings from their JCS paper with Claudine Kraft & team @kraftlabfr.bsky.social. journals.biologists.com/jcs/article/...

Excited to share our latest publication! 🎉 Here @sophiezoe.bsky.social reveals an early developmental time window determining initial growth direction of lateral roots. Wonderful collaboration with @wabniklab.bsky.social and @matesf.bsky.social lab www.pnas.org/doi/10.1073/... @cibss.bsky.social

SHOOT GRAVITROPISM 9 links sensory timing to the initial lateral root growth angle | PNAS

Plants strategically respond to gravity and actively set defined growth angles. These gravitropic set-point angles (GSAs) shape the width and depth...

pnas.org

We are pleased to congratulate Jana Elsässer on the successful defense of her doctoral thesis at the University of Freiburg! Jana conducted her research as part of project B10 under the supervision of SFB 1381 PI Claudine Kraft. @biologyunifreiburg.bsky.social @kraftlabfr.bsky.social

Thanks to @cibss.bsky.social for recognizing Mariya, Riccardo and Hector from the lab with the CIBSS Award 2026, for our recent publication! Glad to be part of such a collaborative research environment. 📄: www.nature.com/articles/s41...

First ERC Synergy meeting with @martenslab.bsky.social and @jimhurley.bsky.social in Vienna, great start! Thanks Sascha for hosting 🙏 @erc.europa.eu

#JobAlert The @biologyunifreiburg.bsky.social of @uni-freiburg.de invites applications for a Professorship (W3) for Plant Biotechnology. ❗Application Deadline: 10 July 2026 🔗https://kurzlinks.de/1iyt #SignalsOfLife #PlantScience #CIBSS

Last week to submit your abstract to the Swiss Autophagy Conference 2026 (3-4 Sept, Fribourg)! A dynamic meeting for PhDs, postdocs & early-career researchers to present, learn & connect. Theme: Autophagy in Development, Disease & Ageing. 📝 Abstracts: 21 June: meetings.ls2.ch/autophagy-2026

Safe to say that Day 1 of 'Cellular mechanisms driven by phase separation' has been a success so far, with lots of great talks, including a keynote by Karla Neugebauer, and plenty of opportunities to socialise and get to know each other 🙌🏼 #EESPhaseSeparation @embo.org @embl.org

New preprint! Cell division has to happen at the right place but how Archaea pick that place is unknown. We now identified a three-protein system, Dip, that positions the divisome at midcell in H. volcanii and is broadly conserved across Archaea. A thread 🧵 www.biorxiv.org/content/10.6...

Two of our lab members are at the EMBO | EMBL Symposium on cellular mechanisms driven by phase separation this week! 🙌 Come and visit their posters: 📌 Mariya → Poster #114 📌 Joachim → Poster #54 #EESPhaseSeparation @events.embl.org @embo.org @embl.org

A new preprint from the lab showing how Atg1 regulates the BLTP Atg2. This study was spearheaded by Sonja Achleitner and Susanna Tulli, involving a fantastic collaboration with @ainaraclaveras.bsky.social and Gerhard Hummer. @maxperutzlabs.ac.at @viennabiocenter.bsky.social @maxplanck.bsky.social

Our ULK1–MTFR1L paper is now officially in @jcellsci.bsky.social, a good moment to reshare it. 🎉 The work identifies MTFR1L as a key coordinator of mitochondrial fission, mitophagy initiation and apoptosis. 👉 Paper: doi.org/10.1242/jcs....

A ULK1–MTFR1L feedback loop links mitochondrial fission, mitophagy and apoptosis

Summary: MTFR1L acts at mitochondrial mitophagy initiation sites, linking mitochondrial fission with autophagy by interacting with ULK1, regulating ATG13 stability, and forming a feedback loop that su...

doi.org

Congratulations to our SFB 1381 PIs Claudine Kraft and Carola Hunte and their teams - great story on the link between the mitochondrial fission and autophagy machinery!

Claudine Kraft's Lab @kraftlabfr.bsky.social · 5mo ago

🚨 Paper Alert! In this new work published in @jcellsci.bsky.social we shift our focus on MTFR1L and the feedback loop linking mitochondrial fission, mitophagy and apoptosis. MTFR1L emerges as a critical coordinator of the fission and autophagy machinery. 🔗Find the paper here: doi.org/10.1242/jcs....

🚨 Paper Alert! In this new work published in @jcellsci.bsky.social we shift our focus on MTFR1L and the feedback loop linking mitochondrial fission, mitophagy and apoptosis. MTFR1L emerges as a critical coordinator of the fission and autophagy machinery. 🔗Find the paper here: doi.org/10.1242/jcs....

New pre-print from the lab! We show that the subtilase SBT12a is essential for symbiosome stabilization in Medicago. Using HUNTER proteomics, we even got some of its substrates. Have a look. www.biorxiv.org/content/10.6...

What a blast! 🎉 Our International Symposium last week gathered 27 world class speakers and over 200 participants. From electrifying plenary talks to vibrant poster session chats, the energy was palpable and the atmosphere truly unforgettable. A massive thank you to all speakers and attendees!

That's a wrap on the 2nd International Symposium organized by @sfb1381.bsky.social in Freiburg! 🎉 Three days of great talks, fascinating science, and wonderful people. Loved being part of it. Huge thanks for the organisation!

www.nature.com/articles/s41...

Mitochondria contact lipid droplets through the mitochondrial import complex binding to lipid metabolism enzyme Ayr1 - Nature Cell Biology

Heinen et al. show that the mitochondrial import complex recruits lipid droplets to the mitochondrial outer membrane. The mitochondrial import complex binds to the lipid metabolism enzyme Ayr1 and con...

nature.com

We are excited to share our new preprint which is now available to read on biorXiv: doi.org/10.64898/202... 🎉🎉🎉

If you are at #CellBio2025, head over NOW to room 108 to hear about CIBSS and the Clusters of Excellence @immunosens.bsky.social and @cecad.bsky.social. We are looking forward to meet you!

Online now - the Review " #Autophagy regulation by phase separation, avidity, and wetting" from @wilflinglab.bsky.social, @kraftlabfr.bsky.social and co. #BiomolecularCondensates #PhaseSeparation #Wetting #Avidity #Theraeputics Read it here: authors.elsevier.com/sd/article/S...

Physical principles have redefined our understanding of autophagy. In our new @cp-trendsbiochem.bsky.social review, we discuss how phase separation, avidity, and wetting shape autophagy at the molecular level. Great collaboration with @wilflinglab.bsky.social www.cell.com/trends/bioch...

Autophagy regulation by phase separation, avidity, and wetting

Autophagy enables cells to selectively degrade a wide range of macromolecules, and how this process achieves spatial precision within the densely packed cytosol is an active area of investigation. Rec...

cell.com

Congratulations! Our SFB 1381 Principal Investigator Claudine Kraft has been awarded an esteemed ERC Synergy Grant, along with her partners in Vienna and Berkeley.

CIBSS – Centre for Integrative Biological Signalling Studies@cibss.bsky.social · 10mo ago

Congratulations! Claudine Kraft @kraftlabfr.bsky.social receives a prestigious ERC Synergy Grant – to find out why some protein #aggregates can be cleared by #autophagy and others not. She and her partners will harness this knowledge to improve autophagy in #ageing & #disease. 🔗  kurzlinks.de/50j8

Vier #ERCSynergyGrants für Forschende der #UniFreiburg. Insgesamt werden die vier Projekte durch den @erc.europa.eu mit rund 41 Millionen Euro über sechs Jahre gefördert; die #UniversitätFreiburg erhält davon gut neun Mio Euro. ➡️ Mehr zu den geförderten Projekten hier: ufr.link/erc-synergy-grant-25

Congratulations! Claudine Kraft @kraftlabfr.bsky.social receives a prestigious ERC Synergy Grant – to find out why some protein #aggregates can be cleared by #autophagy and others not. She and her partners will harness this knowledge to improve autophagy in #ageing & #disease. 🔗  kurzlinks.de/50j8

ERC Synergy Grant for Prof. Dr. Claudine Kraft

CIBSS speaker Prof. Dr. Claudine Kraft is part of a team receiving an ERC Synergy Grant of ten million euros for her research on how autophagy degrades large protein aggregates in health and disease.

kurzlinks.de

Fantastic teamwork with @kraftlabfr.bsky.social and @jimhurley.bsky.social! Looking forward to exciting discoveries ahead. Many thanks to @erc.europa.eu for funding our proposal. @univie.ac.at @maxperutzlabs.ac.at @viennabiocenter.bsky.social

Max Perutz Labs Vienna@maxperutzlabs.ac.at · 10mo ago

Big news! Group leader Sascha Martens has been awarded a prestigious @erc.europa.eu Synergy Grant for the collaborative project DegrAbility to explore how cells can better recycle harmful protein aggregates linked to diseases like Alzheimer’s ➡️ tinyurl.com/2zuz9jcf @univie.ac.at @meduniwien.ac.at

Thrilled to join you and Claudine to study the cell's own version of Banksy's self-shredding artwork!

New #CORDIS article on work by Claudine Kraft @kraftlabfr.bsky.social l "Autophagy: the cell’s waste disposal system" - work was result of @erc.europa.eu LS1 project "AutoClean" #H2020 #EUfunded cordis.europa.eu/article/id/4...

Autophagy: the cell’s waste disposal system

Research into how cells initiate and regulate autophagy opens the door to new ways of preventing a range of diseases.,,,European Commission

cordis.europa.eu

Back from the 8th NAS Conference in Sånga Säby, and what a wonderful experience it was! Christoph and Franzi represented the lab, and as a cherry on top, Chris won an award for his talk 🎉 Huge thanks to the NAS for organising and always creating such a warm community atmosphere!