Excited to share our substantially updated manuscript, "Rational design of disordered proteins for systematic sequence-to-function investigation"! www.biorxiv.org/content/10.1...

Now published! Big congrats to first author @gginell.bsky.social We are actively working improving/updating various aspects of FINCHES; don't hesitate to reach out if you run into issues, have questions. www.science.org/doi/10.1126/...

Sequence-based prediction of intermolecular interactions driven by disordered regions

Intrinsically disordered regions (IDRs) in proteins play essential roles in cellular function. A growing body of work has shown that IDRs often interact with partners in a manner that does not depend ...

science.org

Alex Holehouse@alexholehouse.bsky.social · 2y ago

Excited to share new work from Garrett Ginell et al where we present an approach for predicting intermolecular interaction driven by disordered regions. We focus on how chemical complementarity can contribute to and even dictate intermolecular interactions www.biorxiv.org/content/10.1...

@bornanovak.bsky.social and @jefflotthammer.bsky.social really did some incredible work here. I might not have had access to most of the lab GPUs for months now, but it was definitely worth it! Check out our preprint for STARLING:

Borna Novak@bornanovak.bsky.social · last yr.

Excited to announce the newest member of the flock - STARLING (conSTruction of intrinsicAlly disoRdered proteins ensembles efficientLy vIa multi-dimeNsional Generative models). www.biorxiv.org/content/10.1...