Happy to share our new study @ijmonod.bsky.social on how surface curvature shapes multicellular organization and function. How curvature controls tissue chirality, patterns distinct architectures, and influences myogenic differentiation? www.biorxiv.org/content/10.6...

Excited to share a new preprint! We address a longstanding question related to stratifying tissues: What are the physical mechanisms that drive epidermal cell delamination? Find out why this👇 traction force pattern emerges and how it is linked to upward cell motion: www.biorxiv.org/content/10.6...

Local mechanical heterogeneity drives epidermal cell delamination https://www.biorxiv.org/content/10.64898/2026.08.30.747990v1

Curvature-guided chiral collective organization of myoblast tissues https://www.biorxiv.org/content/10.64898/2026.08.25.747076v1

Happy to share our new paper @natcomms.nature.com on the role of active nematics on myoblast fusion and myotube growth! www.nature.com/articles/s41... Amazinf work from @dubey837.bsky.social, @yoannletoquin.bsky.social and Aleksandra Ardaševa!

Anger, L., Schoenit, A., Wodrascka, F., Rossé, C., Mège, R.-M., Ladoux, B., & Marcq, P. (2026). Tissue stress measurements with Bayesian inversion stress microscopy. The European Physical Journal E, 49(1-2), 2. #EpithelialMechanicsReview buff.ly/ELaOtv9

Tissue morphogenesis demands massive deformations, yet tissues must stay coherent. This is achieved through cell intercalation, also known as T1 transitions. But what drives them mechanically? I'm @arturruppel.bsky.social, and I'll walk you through the physics, from whole embryos down to four cells

New 📄 🚨! #CellBio is teeming with simulations comprising an extraordinarily high number of components. We argue that model complexity will not automatically lead to a better understanding of biological systems & discuss how modeling practices could be repurposed: arxiv.org/abs/2608.06998 #philsci

Simulating is not always understanding: When model complexity obscures biology

In cell biology, computational models of biological systems range from minimal representations with a handful of parameters to whole-cell simulations tracking thousands of molecular species across a c...

arxiv.org

How do tissues safely remove cells? Join me, @marija-matejcic.bsky.social in this perspective on the past, present and future of epithelial cell extrusion 🧵 0/16

Thrilled to share our new work on the coupling between cell proliferation and intercellular stress organization! Cool collaboration between @bladoux.bsky.social / @rmmege.bsky.social lab and Doostmohammadi lab, combining experiments + simulations. Main points below : www.biorxiv.org/content/10.6...

A principal-stress rule for cell division in epithelia

Dense active materials, from cellular tissues to jammed and glassy systems, must continuously relieve internal mechanical stress to remain structurally stable as they are driven far from equilibrium. ...

biorxiv.org

Thrilled to share our new paper on cell extrusion. A beautiful study with a tremendous amount of data, led by the fantastic @fanny-wodrascka.bsky.social ! www.biorxiv.org/content/10.6...

Clearly, the use of LLMs to summarise and analyse scientific (or otherwise) documents is well justified. Their understanding is, at least, at a human level. The following example (image attached) strongly supports their intellectual capabilities. www.nature.com/articles/d41...

Some people should never have access to students. “AI requires no ramp-ups, no meetings, and absolutely no emotional support…The issue is not whether my students are valuable. In long run, they are invaluable. The issue is that their value emerges slowly, whereas AI delivers immediate returns.”

Why I may ‘hire’ AI instead of a graduate student

“It can competently perform a lot of the work I need immediately,” this professor writes

science.org

We had covered the history of traction force microscopy (TFM) earlier: bsky.app/profile/epim... But what about applying TFM into more physiologically relevant systems, such as those in 3D? I am @barrasa-fano.bsky.social and I'll be your guide through this thread on #3DTractionForceMicroscopy.

Barrasa-Fano, J., Shapeti, A., Apolinar-Fernández, A. et al. Guidance for 3D traction force microscopy today and in the next decade. Nat Methods (2025). #EpithelialMechanics buff.ly/eRFLGkt

Interested in the biophysics of organoids? We just published a review in Dev Cell—take a look! dlvr.it/TPyTb8 #Organoids #Biophysics

Biophysics of organoids

In this review, Weichselberger, Moore et al. discuss how physics-based approaches illuminate organoid development and homeostasis by integrating mechanical, chemical, and informational processes. They...

dlvr.it

Our paper on tissue stress measurements is now out in Eur. Phys. J. E. rdcu.be/eX59E. Great work from @luanger.bsky.social and @andreasschoenit.bsky.social and collaboration with P. Marcq @pmmh-lab.bsky.social Code: github.com/pmarcq/BISM/ and Examples on github.com/ASmushyCell/...

Reviewing process has always been painfull, but it will just become useless and impossible to publish if we start accepting this (we are not helping science...and better refusing to review if you have no time rather than using these tools without filter)

Tissue stress measurements — our latest preprint is out: arxiv.org/abs/2512.00550 (publication coming soon!) Fantastic work by the three musketeers — @luanger.bsky.social, @andreasschoenit.bsky.social and @fanny-wodrascka.bsky.social — in collaboration with P. Marcq!

Tissue stress measurements with Bayesian Inversion Stress Microscopy

Cells within biological tissue are constantly subjected to dynamic mechanical forces. Measuring the internal stress of tissues has proven crucial for our understanding of the role of mechanical forces...

arxiv.org

Finally! 🤩 Our position piece: Against the Uncritical Adoption of 'AI' Technologies in Academia: doi.org/10.5281/zeno... We unpick the tech industry’s marketing, hype, & harm; and we argue for safeguarding higher education, critical thinking, expertise, academic freedom, & scientific integrity. 1/n

📢 PhD Thesis defense 📅 November 26th 📍Institut Jacques Monod Fanny Wodrascka ( @fanny-wodrascka.bsky.social @bladoux.bsky.social @rmmege.bsky.social ) will defend her PhD thesis "Mechanical control of epithelial cell extrusion via RhoA-dependent contractility " ➡️ buff.ly/f5VaVah

My new ImageJ / Fiji toolkit is out 🔥! The goal is to make image handling & visualization easy, with an intuitive interface! Install it on Fiji with the "Image Viewer" update site #microscopy #ImageJ #FluorescenceFriday #microscopyMonday imagej.net/plugins/imag...

Truly honoured and grateful to have received alongside other young researchers the prize "Grandes avancées françaises en biologie" from the @academiesciences.bsky.social for our paper on mechanical cell competition together with @luanger.bsky.social and S. Monfared www.nature.com/articles/s41...

Institut Jacques Monod@ijmonod.bsky.social · 11mo ago

📣 Andreas Schoenit, ( @andreasschoenit.bsky.social ) doctorant en biophysique dans le laboratoire "Adhésion cellulaire et mécanique" est lauréat des Grandes avancées françaises en biologie de la Fondation Mergier Bourdeix ! Plus d'informations 🔗 www.ijm.fr/prix-des-gra...

1/ 🐣⚒️ To study mechanics, we need to apply prescribed forces - how can we do that in living tissues? I am @eigenp.bsky.social and in this thread I'll highlight our new approach for applying tension on epithelial tissues in vivo!

Happy to share the last version of our story @currentbiology.bsky.social on the role of interfacial tension in mechanical cell competition led by @leovalon.bsky.social and Alexis Matamoro Vidal www.sciencedirect.com/science/arti...

Mechanobiology across timescales A Review by Bo Cheng, Moxiao Li, Min Lin, Hui Guo & Feng Xu ⚛️🧪 www.nature.com/articles/s42...

Mechanobiology across timescales - Nature Reviews Physics

This Review explores how cells sense and respond to mechanical signals across timescales. By integrating mechanosensing at membranes, mechanotransduction in the cytoplasm, and nuclear reprogramming, it reveals a role of temporal dynamics in tissue development and disease.

nature.com

John M. Martinis, Michel H. Devoret & John Clarke recount the history of their milestone discovery, which today won the Nobel Prize in Physics go.nature.com/4gVswyS

Quantum Josephson junction circuits and the dawn of artificial atoms - Nature Physics

In 1985, experiments revealed the quantum behaviour of a macroscopic degree of freedom: the phase difference across a Josephson junction. The authors recount the history of this milestone for the development of superconducting quantum circuits.

go.nature.com

We’re organizing a conference at @ijmonod.bsky.social in Paris, January 2026, in memory of M.P. Sheetz — pioneer in cell mechanics and mechanobiology, co-discoverer of kinesin, and founder of @mbisg.bsky.social. Join us to explore his legacy. mikeinmemoriam.sciencesconf.org

Happy to share our new study @ijmonod.bsky.social and @mpi-scienceoflight.bsky.social with C. Duclut and J. Prost. on forces generated by active fluid transport in epithelia and their role in tissue dynamics. Congrats to Huiqiong Wu, G. Arkowitz and R. Chilupuri! www.biorxiv.org/content/10.1...

Regulation of epithelial tissue homeostasis by active trans-epithelial transport

Epithelia are intricate tissues whose function is intimately linked to mechanics. While mechanobiology has primarily focused on factors such as cell-generated contractility and mechanical properties o...

biorxiv.org