FRI at 10AM: @latimes.com journalist Maxwell Williams and UCSF pharmaceutical chemistry professor @amanglik.bsky.social join to talk about the unique scents that surround us in the Golden State. ❓What smell says California to you? Sequoia trees? Ojai tangerines? Ocean spray?

What's that smell? Readers share the scents that remind them of L.A.

From wafting tar pits and smells of the beach to native plants and a chocolate factory, our readers smelled Los Angeles and told us about it.

buff.ly

1/n: 2nd preprint this week: www.biorxiv.org/content/10.1.... We functionalized a G(13)PCR P2RY8 that keeps germinal center (GC) B cells confined. Taylor LaFlam performed saturation mutagenesis, Aashish Manglik's lab solved the structure, and collaboration with Cyster lab validated variant effects.

Phenotypic pleiotropy of missense variants in human B cell-confinement receptor P2RY8

Missense variants can have pleiotropic effects on protein function and predicting these effects can be difficult. We performed near-saturation deep mutational scanning of P2RY8, a G-protein-coupled re...

biorxiv.org

We have deposited the following mice (all B6/J backcrossed) to @mmrrc.bsky.social Adgrf5-EGFP-CT-IRES-CRE GPR123- EGFP-CT-IRES-CRE GPR124- EGFP-CT-IRES-CRE GPR125- EGFP-CT-IRES-CRE Gpr133-EGFP-CT-IRES-CRE GPR156-IRES-Cre GPR156-mGL-IRES-Cre GPR75-IRES-Cre

Please check out our recent work led by brilliant student @matthewkhoward.bsky.social jointly mentored with @willowcoyote.bsky.social. Willow and I are recruiting joint postdocs - contact us!

Matt Howard@matthewkhoward.bsky.social · 2y ago

Happy New Year! (and first post here 😀) Excited to share the final version of our work where we combine deep mutational scanning, cryo-EM, and molecular dynamics to further resolve the mechanisms of pH sensing in GPCRs. 🧵(1/n) www.cell.com/cell/fulltex...

Tune in for @matthewkhoward.bsky.social to give a talk tomorrow! Brilliant student from my and @amanglik.bsky.social’s lab working on transformational DMS approaches for gpcrs. Also right on the heels of his first paper from our labs!!!

Atlas of Variant Effects Alliance@varianteffect.bsky.social · 2y ago

Welcome to the first Variant Effects Seminar Series of 2025! Kicking off on Jan 7 with two amazing speakers: Ujjwal Rathore and Matthew Howard. Don’t miss it! varianteffect.org/seminar-series #FunctionalGenomics #Seminar

First post on bsky to highlight our latest work on smell receptors (www.nature.com/articles/s41...). Odorant receptors are notoriously challenging to work with - we used a classic strategy from protein engineering to get a peek into how these receptors recognize such a diversity of smells.