Institute of Science and Technology Austria (ISTA)

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The Institute of Science and Technology Austria (ISTA) is dedicated to cutting-edge basic research and graduate education. www.ista.ac.at

AlphaFold—an AI tool that revolutionized structural biology and earned the 2024 Nobel Prize in Chemistry—was trained on static crystal structures that dominate protein datasets. However, proteins are highly dynamic molecules. Read more: ista.ac.at/en/news/towa...

Toward Experiment-Guided AlphaFold

The AI-based program AlphaFold predicts a protein’s 3D structure with remarkable accuracy. However, it tends to reduce heterogeneous structures to a single dominant conformation, or shape, and overloo...

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