Graphical abstract of our recent work in @natimmunol.nature.com. STUB1 regulates tumor immunity through targeting cytokine receptors using an as yet unknown selectivity mechanism. We have likened STUB1 to a puppet master, controlling the cytokines T cells can sense. www.nature.com/articles/s41...

Excited to share our paper in @natimmunol.nature.com! Using in vivo #CRISPR screens we identify the E3 ligase STUB1 as a new cancer immunotherapy target in CD8 T cells. STUB1 is a dual function target: STUB1 KO promotes CD8 responses and STUB1 KO hinders tumor cells. www.nature.com/articles/s41...

A STUB1–CHIC2 complex inhibits CD8+ T cells to restrain tumor immunity

Nature Immunology - LaFleur, Milling et al. perform an in vivo CRISPR screen of CD8+ T cells responding to tumors. They identify the E3 ubiquitin ligase STUB1 as a potent negative regulator of CD8+...

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