After 30+ years of HIV vaccine clinical trials, this is the first time that neutralizing antibodies against an HIV clinical isolate has been generated in vaccinated people. * "Tier 2" neutralizing antibodies, induced consistently. www.science.org/doi/10.1126/... www.science.org/doi/10.1126/...

Vaccination with an mRNA-encoded membrane-bound HIV envelope trimer induces neutralizing antibodies in animal models

An HIV envelope trimer mRNA vaccine enables membrane-bound expression and produces a functional immunogen in preclinical mammalian models.

science.org

🚨 New preprint! We show that intranasal FluMist vaccination induces local HA-specific memory B cell responses in the upper airway, even in the absence of strong systemic responses. Investigating local immunity will be key to designing improved vaccines for respiratory pathogens.

Prof. Shane Crotty@profshanecrotty.bsky.social · last yr.

In our new study we show local B-cell immunity and durable memory following live-attenuated influenza intranasal vaccination of humans. We utilized minimally invasive swabbing of human upper airway, following seasonal intramuscular or nasal (FluMist) flu vaccinations www.biorxiv.org/content/10.1...