10 years and still standing strong @EMBL 🍾💪 Huge thanks to all members, alumni, supporters & colleagues who made it possible. Here’s to the next decade! 🙏

Ian Guldne, @carolynbertozzi.bskyverified.social, @abu-remaileh.bsky.social & team are exploring relationship between synapse loss & defective protein recycling in the aging brain, offering new insights into brain health & disease risk news.stanford.edu/stories/2026... @brainresilience.bsky.social

Aging slows breakdown of synaptic proteins, raising disease risk

Recent research unveils new links between the brain’s waste management systems and neurodegeneration.

news.stanford.edu

Super interesting work from @carolynbertozzi.bskyverified.social group about the effects of glycosylation in protein structure and function at the proteome scale 🤯💥🤩 Results show that sialylation and fucosylation are crucial, which makes a lot of sense. We did some extra bits 🧐 with GlycoShape ⬇️🧵

Carolyn Bertozzi@carolynbertozzi.bskyverified.social · 8mo ago

Congratulations former postdoc @jfhevler.bsky.social (in transit to Roche) and the team on their work using thermal proteome profiling along with glycosylation perturbagens to discover glycan-dependent protein functions at the proteome scale 👏 www.biorxiv.org/content/10.6...

(1) Happy to share our latest work: We developed an approach to systematically investigate how glycosylation controls protein function across the proteome—and what goes wrong when it is disrupted. www.biorxiv.org/content/10.6...

Discovering Glycosylation-Dependent Protein Function by Thermal Proteome Profiling

Protein glycosylation regulates essential cellular processes including protein folding, stability, and cell-cell interactions; however, how aberrant glycosylation impacts protein function and interact...

biorxiv.org

Congratulations to my very good friend @jfhevler.bsky.social on this amazing pre-print on how mass-spec and MD simulation can enable functional analysis of protein glycoforms. It was a privilege to play a small part in this project and learn a lot from Johannes! #Glycotime #carbohydrate #Proteomics

Carolyn Bertozzi@carolynbertozzi.bskyverified.social · 8mo ago

Congratulations former postdoc @jfhevler.bsky.social (in transit to Roche) and the team on their work using thermal proteome profiling along with glycosylation perturbagens to discover glycan-dependent protein functions at the proteome scale 👏 www.biorxiv.org/content/10.6...

For those who perform thermal proteome profiling (TPP) experiments, you might find this new data analysis approach (and open source Python software) useful. Developed by postdoc @jfhevler.bsky.social 🙏 arxiv.org/abs/2508.096...

Thermal Tracks: A Gaussian process-based framework for universal melting curve analysis enabling unconstrained hit identification in thermal proteome profiling experiments

Thermal Tracks is a Python-based statistical framework for analyzing protein thermal stability data that overcomes key limitations of existing thermal proteome profiling (TPP) work-flows. Unlike stand...

arxiv.org

🕷️ Spiders from our blood 🕷️ Check out our new paper from @hecklab.bsky.social describing how the spider-like immune regulator C4BP interacts with its native binding partners. 🔗 www.mcponline.org/article/S153... #MassSpec #StructuralBiology

Structural Insights into Complement Inhibition: Visualizing Distinct Binding Modes of C4b-binding Protein Complexes with C4b and SAP

C4b-binding protein (C4BP) is an innate immune inhibitor found in serum. Human C4BP adopts spider-like higher-order structures (HOS) formed by disulfide-linked C4BPα and C4BPβ chains that non-covalent...

mcponline.org

Faster and more accurate protein modeling with CryFold. By focusing on nearby points (Local Attention) and employing map masking, CryFold excels in generating models from challenging maps regions. It enables a more cost-efficient model building. 🧵 💾 github.com/SBQ-1999/Cry...