Thrilled to share our latest work in @natcomms.nature.com ! MICAL1 mediates shear-dependent actin remodeling, enabling GPIb-IX-V mechanotransduction and platelet function, and reveals a previously unrecognized role for actin oxidation #mical1 #platelets #cytoskeleton #vwf #gpib

Alex K@alexkzis.bsky.social · 12mo ago

Excited to share that our paper is out in @natcomms.nature.com 🔗 rdcu.be/ez3Gt We uncover how MICAL1 regulates actin dynamics to enhance VWF–GPIbα binding in platelets. Big thanks to all co-authors & collaborators ! @hithlabinserm1176.bsky.social @echardlab-pasteur.bsky.social

The @hithlabinserm1176.bsky.social is proud to support #ISTHEarlyCareer by leading educational sessions at #ISTH2025!

💡Honoring the impact & memory of the late Claire McLintock, this @ISTH.org grant supports #ISTHEarlyCareer innovative research in women's health issues in #thrombosis & #hemostasis. Learn more ⬇️and apply by ⏳ Sept. 1! t.co/QYL9cUcoav Thank you to all donors who supported this grant! #ISTH2025

The @hithlabinserm1176.bsky.social is ready for #ISTH2025!

🌟 #ECTH2025 is just around the corner! 🌟 Join us in Prague to explore the latest discoveries in #thrombosisandhaemostasis in a beautiful place rich in culture. 🔗 Register here to secure early bird rates: www.ecth.org/registration/ Curious about CzechFunFact #2? #ECTH2025 #ECTHJAB #CzechFunFacts

A special day: Jean Solarz, my first PhD student, successfully defended his thesis. Proud of all the work accomplished! Thks to jury members.

HITh lab InsermU1176@hithlabinserm1176.bsky.social · last yr.

Huge congratulations to Dr Jean Solarz for brilliantly defending his PhD today! And to his supervisors @alexkzis.bsky.social and Frederic Adam. We are very proud of you! A big thank you to all the committee members Prof N Ajzenberg, Dr MP Gratacap, Dr G Romet-Lemonne, Dr Leon, and Dr Ho-Tin-Noe

Huge congratulations to Dr Jean Solarz for brilliantly defending his PhD today! And to his supervisors @alexkzis.bsky.social and Frederic Adam. We are very proud of you! A big thank you to all the committee members Prof N Ajzenberg, Dr MP Gratacap, Dr G Romet-Lemonne, Dr Leon, and Dr Ho-Tin-Noe

#ECTH2025 is just around the corner! Join us to explore the latest discoveries in #thrombosisandhaemostasis in a beautiful place rich in culture and steeped in history! 🔗 Register here to secure early bird rates: www.ecth.org/registration/ #ECTH2025 #ECTHJAB #CzechFunFacts

#ECTH2025 outstanding lineup of speakers - leaders, innovators, experts in #thrombosis & #haemostasis #ECTH @sophiesusen.bsky.social @cjbinder.bsky.social @cedrichermans.bsky.social

The lab was present at #WFHCCS2025 in Dubai! #VWF #VWD #science #WFH @hithlabinserm1176.bsky.social @caterinacasari.bsky.social

Caterina Casari@caterinacasari.bsky.social · last yr.

It has been a honor to speak at the #WFHccs2025 in Dubai and share the stage with Drs Michelle Lavin and Augusto Federici! Thanks #WFH for this opportunity!

Happy to share our latest work! Early view on Haematologica Journal ➡️ haematologica.org/article/view... #nonfactortherapies #FVIII #hemophiliaA #thrombosisandhaemostasis

Important paper from the ISTH SSC Platelet Physiology group! Congrats @alexkzis.bsky.social @dianvanderwaldr.bsky.social and all the authors! @isth.org @jthjournal.bsky.social #platelets #thrombosisandhaemostasis

Alex K@alexkzis.bsky.social · last yr.

We have worked for 2 years with @dianvanderwaldr.bsky.social to propose a protocol for platelet desialylation, and we are excited to now share it. Communication from the ISTH SSC Platelet Physiology. - Journal of Thrombosis and Haemostasis www.jthjournal.org/article/S153... #hemsky #hemesky

New day, new presentation at #SFH2025 Congrats Jean Solarz-PhD student in our group- for his great presentation! #platelets #thrombosisandhaemostasis

Alex K@alexkzis.bsky.social · last yr.

Bravo Jean Solarz for your presentation at the French Society of Hematology on MICAL1 @hithlabinserm1176.bsky.social #sfh #Hemsky #hemesky

Congratulations Toscane Viellard -PhD in our group- for her excellent presentation at #SFH2025 #platelets #thrombosisandhaemostasis

If you missed our paper on the humanized murine model of VWD-type 1 (hVWD1) you can read it haematologica.org/article/view... The model provides a novel platform to test therapeutic options for #VWD one of which is explored in the paper! Thanks Haematologica for the highlight as Editor’s pick!

🎉Huge congratulations to Dr Claire Auditeau 🎓 for brilliantly defending her PhD today! And to her supervisors Pr Delphine Borgel and Dr Francois Saller! A big thank you to all the committee members Pr Angelillo-Scherrer, Pr Garçon, Dr Allali, Pr Frere! Happy and proud of your achievement!

Happy to share our latest collaborative work on the characterization of the Afro-Caribbean #VWD cohort in Martinique island! Congrats Dr Marie-Daniela Dubois and all the authors! onlinelibrary.wiley.com/doi/10.1111/...

Clinical, Phenotypic and Genotypic Characteristics of Von Willebrand Disease in Afro‐Caribbeans: Results From a Study in Martinique Island, French West Indies

Background Several cohort studies have investigated the molecular basis of von Willebrand disease (VWD); very few have focused on the Afro-Caribbean population. Objectives To determine the genotyp...

onlinelibrary.wiley.com

Our lab is glad to collaborate with both teams! 🥳

Alex K@alexkzis.bsky.social · last yr.

Great collaboration with Hana Raslova and @alessandrabalduini.bsky.social teams on BSS signaling defect! Recently published. @hithlabinserm1176.bsky.social haematologica.org/article/view...

The JAB is working hard alongside the @ECTH Board to shape a congress that truly supports and empowers #EarlyCareer scientists! You can already submit your abstract for #ECTH2025 here: www.ecth.org/abstracts/

Congratulations to our colleague @Dr Jildaz Caroff for successfully obtaining his HDR (Habilitation à diriger des recherches)!! 👏🏻👏🏻👏🏻👏🏻

In the @hithlabinserm1176.bsky.social we love to collaborate! Check out this very interesting paper by @Prof Elisa Rossi with valuable contributions by @alexkzis.bsky.social and @ceciledenis.bsky.social from our group! www.nature.com/articles/s42...

Thrombin cleaves membrane-bound endoglin potentially contributing to the heterogeneity of circulating endoglin in preeclampsia - Communications Biology

Thrombin cleaves membrane-bound endoglin and soluble endoglin, releasing fragments of varying sizes; these findings emphasize the heterogeneity of sEng in preeclampsia, connecting endothelial dysfunct...

nature.com

👏An incredible session by 3 incredible women during the #gth2025 with Alessandra Balduini on Red blood cells prod, Catherine Strassel on platelet prod and Caterina Casari with bioinspired platelets. @alessandrabalduini.bsky.social @caterinacasari.bsky.social

Great presention of Caterina Casari during the #GTH2025 on SynthoPlates. When art meets science. 🇨🇭 @caterinacasari.bsky.social #womeninscience #synthoplates

The lab is at #GTH2025 in Lausanne with Caterina, Jean and Alex! Jean has already presented his study, but don't miss Caterina tomorrow with the SynthoPlates! @caterinacasari.bsky.social @alexkzis.bsky.social #Science #congress #switzerland

The lab is at #GTH2025 in Lausanne with Caterina, Jean and Alex! Jean has already presented his study, but don't miss Caterina tomorrow with the SynthoPlates! @caterinacasari.bsky.social @alexkzis.bsky.social #Science #congress #switzerland

Great presentation by PhD student Jean Solarz at #GTH2025 in Lausanne this morning! We are very proud of you! @alexkzis.bsky.social @hithlabinserm1176.bsky.social

Honored to be invited at the Scientific Days of the Graduate School Health and Drug Sciences #HeaDS and OI HEALTHI #universityparissaclay to present our project that was awarded a “Technics” grant! @hithlabinserm1176.bsky.social

Presentation by Peter Lenting at #EAHAD2025 on Opportunities and Challenges of Novel Therapies @hithlabinserm1176.bsky.social

Our colleague @alexkzis.bsky.social was invited by #RFTH Hémostase for the annual “best of hemostasis 2024” webtv show with our friends @cedrichermans.bsky.social Annabelle Dupont, Patrick Mismetti & Yves Gruel!

Alex K@alexkzis.bsky.social · 2y ago

Very proud to be invited to the RFHT journal for the Year of hemostasis. Was an amazing experience. #rfht

La Société Française de Thrombose et d’Hémostase (SFTH) est désormais sur Bluesky ! 🌟 Rejoignez-nous pour échanger autour de l’hémostase, de la thrombose et de l’innovation scientifique. Suivez-nous pour rester informés de nos actualités et événements ! 🩸💬 #SFTH #Thrombose #Hémostase #Medsky