Our mentor Casey Brown, apart from being an extraordinary scientist, was a brilliant teacher who loved everything genetics. In his honor, some of the world's leading experts came together to create the 'Casey Brown Lecture Series' on human genetics 1/ shorturl.at/eCm7S

Casey Brown Lecture Series - YouTube

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Excited to share our latest work! We find that common-variant GWAS and rare-variant burden tests prioritize genes in fundamentally different ways, with important implications. Check out Jeff’s excellent thread below👇

Jeff Spence@jeffspence.github.io · 2y ago

What do GWAS and rare variant burden tests discover, and why? Do these studies find the most IMPORTANT genes? If not, how DO they rank genes? Here we present a surprising result: these studies actually test for SPECIFICITY! A 🧵on what this means... (🧪🧬) www.biorxiv.org/content/10.1...

Depending on how you count them there's something like 13000 unique traits in the @gwascatalog.bsky.social Most new gwas add to our knowledge of these traits. But some new gwas introduce new traits: VICM = citrullonated and MMP degraded vimentin, a biomarker pubmed.ncbi.nlm.nih.gov/38155185/

Citrullinated and MMP-degraded vimentin is associated with chronic pulmonary diseases and genetic variants in PADI3/PADI4 and CFH in postmenopausal women - PubMed

Citrullinated vimentin has been linked to several chronic and autoimmune diseases, but how citrullinated vimentin is associated with disease prevalence and genetic variants in a clinical setting remai...

pubmed.ncbi.nlm.nih.gov