Glad to see this out! Led by postdoc Ana Kutschat, we found that ARID5B, associated with leukemia predisposition, acts as a transcriptional repressor by recruiting HDACs on chromatin

St. Anna Children's Cancer Research Institute (CCRI)@stanna-ccri.bsky.social · 2mo ago

🚨New paper alert! Researchers in Davide Seruggia's lab unraveled a new molecular mechanism that could predispose children to develop leukemia: ccri.at/mechanism-of... The team found that the protein ARID5B regulates normal B cell development, and alterations in ARID5B could increase leukemia risk.

🧬How inherited DNA changes contribute to childhood #leukemia A new study from CeMM Adjunct PI @dseruggia.bsky.social's group at @stanna-ccri.bsky.social reveals how ARID5B guides immune cell development & how its loss may raise B-cell leukemia risk ➡️ bit.ly/4xZO4CK 📄 bit.ly/43RSc9X

🧪The lab of @dseruggia.bsky.social's at @stanna-ccri.bsky.social explores gene regulation in pediatric #leukemia. “Most of what we learn in cancer research in adults does not apply to pediatric cancer,” he said at the 𝘞𝘪𝘦𝘯𝘦𝘳 𝘒𝘰𝘯𝘻𝘦𝘳𝘵𝘩𝘢𝘶𝘴. 👉 bit.ly/4dUbn9q

🧬 𝗔 𝗻𝗲𝘄 𝗮𝗽𝗽𝗿𝗼𝗮𝗰𝗵 𝘁𝗼 𝗳𝗶𝗴𝗵𝘁 𝗰𝗵𝗶𝗹𝗱𝗵𝗼𝗼𝗱 #𝗹𝗲𝘂𝗸𝗲𝗺𝗶𝗮 In a @natcomms.nature.com paper, researchers from @dseruggia.bsky.social's group at @stanna-ccri.bsky.social & CeMM show that collapsing the SAGA scaffold destabilizes & degrades KAT2A, stopping #AML cell growth. 🔗 bit.ly/484XvFv 📄 bit.ly/4cPghT5

What are the roles of UFMylation during ribosome-associated quality control? @gekaragoz.bsky.social @plantophagy.bsky.social and colleagues find it to cooperate with RQC factors in promoting clearance of arrested nascent polypeptides at the ER link.springer.com/article/10.1...

The coordinated action of UFMylation and the RQC pathways clears arrested polypeptides at the ER - The EMBO Journal

Clearance of arrested nascent polypeptides resulting from ribosomal stalling is essential for proteostasis. Stalled endoplasmic reticulum (ER)-bound ribosomes are marked by ubiquitin-fold modifier 1 (...

link.springer.com

I’m very happy to be part of our FWF “Emerging Fields” consortium! Together with @gekaragoz.bsky.social, @sebastianfalk.bsky.social and CCRI/CeMM/VetMedUni colleagues Eleni Tomazou, @dseruggia.bsky.social and @floriangrebien.bsky.social, we will study the ribosome code in pediatric cancers.

Max Perutz Labs Vienna@maxperutzlabs.ac.at · 6mo ago

A strong Perutz presence in a new @fwf-at.bsky.social consortium: @elifkaragoz.bsky.social will coordinate the Emerging Fields project 'Translating the Ribosome Code of Pediatric Cancers' 🤝 The team includes @sebastianfalk.bsky.social and @marco.heinlab.org ➡️ tinyurl.com/3d6z3ry5

Nucleotide-resolution mapping of regulatory elements via allelic readout of tiled base editing @natcomms.nature.com @dseruggia.bsky.social @lucapinello.bsky.social @danielevanbauer.bsky.social www.nature.com/articles/s41...

Happy to share our paper in collaboration with cancerbits.bsky.social. We used machine learning & ATAC-seq to refine erythroid differentiation protocols. Recipes for lineage differentiation are written on chromatin! @stanna-ccri.bsky.social @cemm.oeaw.ac.at

Nucleic Acids Research@narjournal.bsky.social · 6mo ago

⭐ #NARBreakthrough! ⭐ 🔬Using ATAC-seq to measure #chromatin #accessibility, researchers predicted early conditions that would yield successful #differentiation, improve erythroblast production, and identify signals that further boost #efficiency. @stanna-ccri.bsky.social 📖 doi.org/10.1093/nar/...

If you want to become an expert in #zebrafish research, apply for the 2026 Zebrafish Development & Genetics course! You will be working in small groups taught by leaders in the field, which can be a transformative experience! Application deadline: March 2 www.mbl.edu/education/ad...

📣 Join the @viennabiocenter.bsky.social #SummerSchool 2026! Check out the opening in CeMM Adjunct PI @dseruggia.bsky.social's lab & work on targeting chromatin regulators in leukemia. Find out more & apply now ➡️ bit.ly/4plpBmI

Vienna BioCenter Scientific Training@vbcscitraining.bsky.social · 8mo ago

The Vienna BioCenter Summer School 2026 call is now open for talented undergrads, it's a great opportunity for students who are interested in graduate study in the life sciences. Davide Serrugia from CeMM is recruiting! Please share https://training.vbc.ac.at/summer-school/

Join us for the second iteration of our yearly, St. Anna CCRI Symposium. This year, we will host experts in Cell Fate in Cancer and Development. Don't miss it!

⬇️ Our latest work on the #SAGA complex - see thread from @paulbatty1.bsky.social ⬇️

Paul Batty@paulbatty1.bsky.social · last yr.

I am pleased to share a new preprint from my postdoc in the @dseruggia.bsky.social lab. We discovered a structural dependency within the CORE module of the transcriptional coactivator SAGA, which regulates the stability of its histone acetyl transferase, KAT2A. www.biorxiv.org/content/10.1... 1/n

I am pleased to share a new preprint from my postdoc in the @dseruggia.bsky.social lab. We discovered a structural dependency within the CORE module of the transcriptional coactivator SAGA, which regulates the stability of its histone acetyl transferase, KAT2A. www.biorxiv.org/content/10.1... 1/n

Disruption of the SAGA CORE triggers collateral degradation of KAT2A

The SAGA transcriptional co-activator complex regulates gene expression through histone acetylation at promoters, mediated by its histone acetyl transferase, KAT2A. While its structure and function ha...

biorxiv.org

This also reminds us what an emotional rollercoaster science can be! :)

CeMM@cemm.oeaw.ac.at · last yr.

🔬 Today’s #EquationsForLife features Adjunct PI @dseruggia.bsky.social’s group (@stanna-ccri.bsky.social)! The lab studies how noncoding regulatory sequences influence gene control in childhood #leukemia, using the #PoissonDistribution to identify protein binding sites. 🔎 bit.ly/3FHPUlg

In a couple of days at Van Swieten Saal in Vienna: join us for an immersive afternoon with six fantastic speakers, and learn more about #pediatric #cancer & #epigenetics.

St. Anna Children's Cancer Research Institute (CCRI)@stanna-ccri.bsky.social · 2y ago

🚨Registration deadline for St. Anna CCRI #Cancer #Epigenetics Symposium this Sunday, January 12th! More Info and registration here >>> ccri.at/st-anna-ccri... Don’t miss this incredible opportunity—secure your spot now!

📣Funded #PhDposition! – Pls RT! Looking for a passionate PhD student to explore cellular crosstalk in #TumorMicroenvironment combining #organoids #scRNAseq &high-res imaging. Join us @VetmeduniVienna in a vibrant research environment! #CancerResearch #PhD 👉 euraxess.ec.europa.eu/jobs/302158

Let's start with a group picture of the seruggialab.com 🐁🩸🧬 :)