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Alaska Pokhrel

@alaskapokhrel.bsky.social

Postdoctoral Research Associate |Australian Institute for Microbiology and Infection, UTS | Infection Microbiology

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PLOS Biology @plosbiology.org · last yr.

Uropathogenic #Ecoli #UPEC proliferate as round coccoid cells during intracellular infection; @alaskapokhrel.bsky.social @bill-lab.bsky.social &co show that accelerated division via FtsZ constriction drives this, the coccobacillus form persisting for generations @plosbiology.org 🧪 plos.io/4gdx97i

Divisome dynamics in intracellular UPEC cells during infection. Left: Representative confocal image of intracellular UTI89 expressing a division marker (FtsZ-mCitrine; pseudo coloured green) with mCherry (pseudo coloured magenta) as cytoplasmic marker, bladder cell membranes shown in blue (CellBrite Steady Membrane 405) and nuclei shown in gold (NucSpot Live Cell 650). Right: Still images of a time-lapse sequence showing FtsZ-mCitrine (pseudo coloured green) driven coccobacilli divisions imaged using HiLo illumination.