Delighted to share the launch of the Cambridge-led, £50m MRC Centre of Research Excellence in Mitochondrial Genome Therapeutics (CoRE-MitoGT). Over 14 years, we will unite international expertise to understand mtDNA disease & develop therapies targeting its root causes. www.ukri.org/news/mrc-fun...

MRC funds world-class research into fatal genetic diseases

The Medical Research Council (MRC) has invested £50 million into the study of mitochondrial diseases to improve treatments.

ukri.org

Excited to share our story published today @nature.com! 🔗 www.nature.com/articles/s41... Read about how we uncover the molecular mechanisms that enable Cas9 to bind and cleave negatively supercoiled ((-)SC) off-targets! Have a quick read of some of the key events in the thread below🧵:

Quentin Smith@qmsmith.bsky.social · 5mo ago

1/11 In our story out today in @nature.com , we showcase the molecular mechanisms that enable Cas9 to bind and cleave negatively supercoiled ((-)SC) off-targets! 🧬🧵 🔗 www.nature.com/articles/s41... #CRISPR #Cas9 #DNATopology #AFM #CryoEM #SingleMolecule #Biophysics

I made a video summary of our recent paper on mitochondrial trafficking. 🔬🧫🧬Check out the paper here: doi.org/10.1083/jcb.... @jclandoni.bsky.social @sulianamanley.bsky.social @jcb.org youtu.be/Az8xzdO0nVU?... #mitochondria #imaging #fluorescence #organelle

Mitochondrial trafficking to maintain network morphology

YouTube video by Julius Winter

youtu.be

In @jcb.org, the @sulianamanley.bsky.social group reveal that perinuclear #mitochondria form a source population, w/ biased anterograde transport spreading material to maintain network connectivity & balanced mitochondrial mass across the cell rupress.org/jcb/article/...

@julius-w.bsky.social @jclandoni.bsky.social @sulianamanley.bsky.social et al reveal that perinuclear #mitochondria form a source population, w/ biased anterograde transport spreading material to maintain network connectivity & balanced mitochondrial mass across the cell rupress.org/jcb/article/...

We had such a fun ERC Synergy @erc.europa.eu kickoff workshop for our 6-year MitoContact collaborative project with our partners Kai Johnsson and Wanda Kukulski! Wonderful to share science, ideas, and play games together 💚 fantastic organization by @zimmerli.bsky.social @jclandoni.bsky.social

Thanks for highlighting our work on combining AI-based organelle dynamics detection in phase contrast with fluorescence! www.nature.com/ncomms/edito... @natcomms.nature.com and Nelio Rodriguez. Spearheaded by @wl-stepp.bsky.social with collaborators @jclandoni.bsky.social @maweigert.bsky.social

I’m honored to be part of the next GRS Single Molecule Approaches to Biology, thanks Chairs @qmsmith.bsky.social and Alba Gomez Segalas for organizing this great event! The GRS is a wonderful opportunity for young scientists to share their exciting science and build communities. See you there!

Quentin Smith@qmsmith.bsky.social · 7mo ago

🗣️ Keynote Speaker: @sulianamanley.bsky.social 👥 Mentoring Session: Careers Across Biophysics featuring @valdavinson.bsky.social @timcraggs.bsky.social @sulianamanley.bsky.social @esisamakis.bsky.social 📈 Selected talk and poster presenters: You! ☀️ Please repost, share and we'll see you in June!

@lycasworks.bsky.social developed quantitative expansion (qExM) to estimate endogenous protein quantities in situ. His ExM protocols offer epitope preservation and accessibility so that standard Western Blot antibodies can be used. Also, check out the cristae, supercomplexes, specialized mitos 🤩

Matt Lycas@lycasworks.bsky.social · 7mo ago

🔬🚨New preprint alert! 🚨🔬 We developed quantitative expansion microscopy (qExM) - a method to accurately count proteins in situ by combining expansion microscopy's improved labeling with statistical estimators borrowed from ecology www.biorxiv.org/content/10.6... #SuperResolution #CellBiology

Ultra excited to launch an ERC Synergy project with amazing partners Kai Johnsson @mpi-mr.bsky.social & Wanda Kukulski @unibe.ch! MitoContact will reveal how contacts between identical organelle partners can yield a diversity of important functions, via dynamics, structure and physiology.

I’m excited about this unique meeting, which will bring together some of my favorite scientists working on organelle biophysics and mechanics! I hope to see some of you in beautiful Barcelona in February. Deadlines have been extended: Dec. 8 abstracts Dec. 20 registration

EMBO@embo.org · last yr.

Sign up now for EMBO Workshop "Intracellular mechanics and organelle #mechanobiology" in Barcelona, Spain, 16–20 Feb 2026! Registration Deadline (in person/virtual): 15 Dec 2025/1 Feb 2026 Abstract Submission Deadline: 14 Nov 2025 meetings.embo.org/event/26-org... #EMBOmechanobio #EMBOevents 🧪

This was a delightful meeting, thank you @nynkedekkerlab.bsky.social, @achilleskap.bsky.social , & @lumicks.bsky.social . I had a great time meeting UK’s young single molecule enthusiasts, so many exciting posters!

LUMICKS@lumicks.bsky.social · last yr.

Better late then never: we hadn't yet send out a thank-you to the UK Bluesky single-molecule community, so here goes: THANKS to all who contributed to the UK SMBio 2025 -- we had a blast! 🙌🏼 Especially to @nynkedekkerlab.bsky.social & @achilleskap.bsky.social for co-organizing 🙏🏼!

Interesting! Scientists outside of Europe looking to move to the EU or Switzerland can benefit from this funding opportunity, it includes up to an additional €2 million beyond the grant cap for setup costs.

European Research Council (ERC)@erc.europa.eu · last yr.

The ERC welcomes the offer of substantial additional budget from @ec.europa.eu for the development of a new ERC funding instrument offering larger, longer-term grants, as announced by President Ursula Von der Leyen at the Sorbonne this morning. 👉 europa.eu/!NTYTTV

Our latest preprint www.biorxiv.org/content/10.1..., describes Willi Stepp’s project to make smart microscopy even gentler by doing event detection in phase contrast. We developed neural networks to detect mito-LD and mito-lysosome contacts, as well as mitochondrial pre-fission constrictions.

Following the great success of the 2024 event, @ox.ac.uk and LUMICKS proudly present the second UK-Ireland symposium focusing on single-molecule research! The abstract deadline, 7 March, is approaching fast. Secure a talk or poster by registering now > bit.ly/4gYPPpQ

Rockin’ out at EMBO in situ with @lycasworks.bsky.social @jonasries.bsky.social Christian Zimmerli, Mark Bates 🤘🔬

MBL Physiology is totally invigorating, it’s a joyful mixture of: frontier scientific discoveries, kick-a$$ microscopes, and lovely, brilliant, generous ppl. I can’t wait for the summer!

Gladfelter Lab@gladfelterlab.bsky.social · 2y ago

The deadline to apply for the MBL Physiology course is fast approaching, January 27th! Consider applying to this amazing, life-changing research discovery experience in Woods Hole! www.mbl.edu/education/ad...

This was an amazing collaboration, we had the luxury of years of great conversations with @wallaceucsf.bsky.social and his team, as well as our other @HFSP partners @anjbadri.bsky.social and Johan Paulsson. Thanks for telling the story here, Wallace!

Wallace Marshall@wallaceucsf.bsky.social · 2y ago

Mitochondria consist of networks of cylindrical tubes, right? Not necessarily! - in our new preprint, @gavsturm.bsky.social investigates how mitochondria transiently adopt a beads-on-a-string morphology www.biorxiv.org/content/10.1...

Stoked to share TWO preprints on mitochondrial pearling! 🎉 We uncover how spontaneous #mitochondria pearling drives #mtDNA nucleoid distribution (doi.org/10.1101/2024...), and @gavsturm.bsky.social et al. dissect the biophysics behind it (doi.org/10.1101/2024...). Details below! 🔬🧵🧪

I’m ultra excited about our preprints on mitochondrial pearling. In two concurrent collaborative studies with @wallaceucsf.bsky.social, we investigated its consequences on mtDNA nucleoids (led by @jclandoni.bsky.social) & its biophysical causes (led by @gavsturm.bsky.social). Funders HFSP, ERC, SNSF

I’m excited to join this session organized by Assaf Zaritsky and Megan Driscoll for the "Beyond Pretty Pictures" subgroup. I’ll share our latest on Smart Microscopy and mitochondria. #cellbio2024 @ascbiology.bsky.social Sat. Dec. 14, 11:15am, Rm 30C plan.core-apps.com/ascbembo2024/e…

We are so excited that @janfunkey.bsky.social has agreed to give the keynote seminar for @qiatcshl.bsky.social 2025 @cshlnews.bsky.social! 🔬🖥️ 🛤️ Applications due 1/31/2025. t.co/x87ngy34UC

Still on my oldies kick. Schwann proposed in his MDCCCXLVII monograph that muscle came from cell coalescence. "filaments are formed, which, in some situations, have an appearance like strings of pearls ... At a subsequent period, all trace of granules or division in the filament vanishes ..."

I’m reading some old mito classics, Margaret Reed and Walter Harmon Lewis with their camera lucida renderings. From various sources I thought the 1914 Science paper was ‘the one’, but on jstor there were no figures. Instead, it’s the 1915 AJA paper that’s a goldmine (Figs 6 & 10). Am I mistaken?

Here is a blue sky — an auspicious sign for the day I joined bluesky? Enjoying lovely Puerto Varas for the Chilean Cell Biology Meeting with my host Veronica Eisner. 💚