Engineered RNA sensors for tuberculosis detection - Nature Chemistry

RNA sensors are challenging to design but hold potential for impactful diagnostics. Now, a multi-faceted approach leverages crowdsourcing and computational automation to enable the design of compact R...

nature.com

BindEnergyCraft: Casting Protein Structure Predictors as Energy-Based Models for Binder Design

Protein binder design has been transformed by hallucination-based methods that optimize structure prediction confidence metrics, such as the interface predicted TM-score (ipTM), via backpropagation. H...

arxiv.org

Deep generative design of RNA aptamers using structural predictions - Nature Computational Science

A deep learning platform for structure-guided, generative design of RNA sequences is developed and used to discover fluorescent RNA aptamers.

doi.org

NuFold: end-to-end approach for RNA tertiary structure prediction with flexible nucleobase center representation - Nature Communications

The 3D structure of RNA is crucial for unraveling its functions. Here, the authors developed NuFold, an end-to-end deep learning-based approach that predicts all-atom RNA 3D structures from sequences....

nature.com

Evolutionary-scale prediction of atomic-level protein structure with a language model

A protein language model enables structure prediction and analysis of more than 600 million metagenomic proteins.

science.org

What’s next for Northwestern researchers amid funding cuts and work stoppages?

Northwestern researchers received notices from the Department of Defense to stop their work immediately.

wbez.org

A nuclear RNA degradation code is recognized by PAXT for eukaryotic transcriptome surveillance

Soles et al. demonstrate that the combination of a 5′ splice site and a poly(A) junction constitutes a nuclear RNA degradation code that targets RNAs for degradation by the PAXT adaptor and the RNA exosome. This study provides fundamental insight into how the RNA exosome specifically recognizes misprocessed RNAs.

dlvr.it

A nuclear RNA degradation code is recognized by PAXT for eukaryotic transcriptome surveillance

Soles et al. demonstrate that the combination of a 5′ splice site and a poly(A) junction constitutes a nuclear RNA degradation code that targets RNAs for degradation by the PAXT adaptor and the RNA ex...

cell.com

A nuclear RNA degradation code is recognized by PAXT for eukaryotic transcriptome surveillance

Soles et al. demonstrate that the combination of a 5′ splice site and a poly(A) junction constitutes a nuclear RNA degradation code that targets RNAs for degradation by the PAXT adaptor and the RNA ex...

cell.com

authors.elsevier.com