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Jingxuan Zeng and colleagues systematically characterise the behaviour defects of aged animals by quantifying changes in locomotor states, event transitions, and behaviour organisation doi.org/10.1242/bio....

The extracellular protease AdamTS-B is a dosage-sensitive regulator of unicellular tracheal branch morphogenesis. Abigail Thuringer and colleagues suggest a potential functional relationship between extracellular proteolysis and EGFR signaling during tracheal development. doi.org/10.1242/bio....

GFP-tagged AdamTS-B accumulates intracellularly and within basal protrusions of tracheal cells.

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Are components of the histone gene expression machinery functionally repurposed in terminally differentiated cells? Xiao-Cui Yang and colleagues provide a new perspective on the pathophysiology of spinal muscular atrophy. doi.org/10.1242/bio....

Localization of NPAT, FLASH and Lsm11 during differentiation of muscle cells.

DMM Journal @dmmjournal.bsky.social · 3w ago

Veronika Kerestes and colleagues provide an analysis of gene expression changes upon Topobexin treatment and TOP2B-knockout in hiPSC derived cardiomyocytes. doi.org/10.1242/bio....

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Renaud Balthazard and colleagues suggest the existence of another layer of control over the cellular metabolism of antigen-presenting cells. doi.org/10.1242/bio....

SNAT2 is ubiquitinated and downregulated from the plasma membrane by MARCH1.

The Company of Biologists @biologists.bsky.social · 3w ago

Haiko Poppinga and colleagues investigate whether memories formed in Drosophila melanogaster larvae persist through metamorphosis. doi.org/10.1242/bio....

No memory through metamorphosis in wild type D. melanogaster after olfactory electric shock conditioning.

Thank you Aaron Reinke for sharing your experience of fee-free #OA publishing @biologyopen.bsky.social via our #ReadAndPublish agreement with University of Toronto Read Aaron’s paper: doi.org/10.1242/bio.... Is your institution participating too? bit.ly/3O7BxGi

Every part of the publishing process in Biology Open was great, and being able to publish fee-free Open Access was the icing on the cake!

In their Methods & Techniques article, Daniel T. Burns and Ken G. Gerow demonstrate that response feature analysis (RFA) has the flexibility to answer questions that traditional repeated measures analyses cannot. doi.org/10.1242/bio....

Creative summary stage using logistic regression. (A) Fitted regressions for all animals. The black horizontal line is set at L≈2.2, which corresponds to 90%. (B) Logits of recovery over time with fitted regression for one study animal (M13). The dashed horizontal line at L≈2.2 (90% recovery) intersects the fitted line at ln(Days)=2.98. The ID is the animal's identification number and M denotes whether the animal was male (M=1) or female (M=0).

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I was incredibly impressed with how fast and smooth the Biology Open review and publishing process was. The submission system was easy to navigate, and the editorial and production teams were responsive and helpful when needed. Most notably, the speed at which my article was reviewed and published was exceptional. My PI remarked that he had never experienced such a quick turnaround in all his years of publishing.

Issue 7 has closed! On the cover: A jewelled blenny (Salarias fasciatus; part of the aquatic and terrestrial Salariini tribe) is seen perched on a reef rock near Lizard Island, from the paper by Cortesi et al. Explore the full issue here journals.biologists.com/bio/issue/15/7

Volume 15 Issue 7 | Biology Open | The Company of Biologists

Biology Open (BiO) is an Open Access journal that publishes rigorously-conducted, high-quality research across the breadth of the biological and biomedical sciences.

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Kirsten Shankie-Williams and colleagues suggest that the emerging non-hormonal zinc-based contraceptive has a first-of-its-kind target; rather than impacting the female reproductive system, zinc can inhibit development of the very-early embryo. doi.org/10.1242/bio....

Percentage of blastocysts that developed from healthy rat embryos extracted from oviducts connected to IUD-treated and control horns at ED2 and cultured until ED5.

The Company of Biologists @biologists.bsky.social · 4w ago

Erik Rollwitz and colleagues show that complete retention and tissue-specific expression of uncoupling protein homoeologs in Xenopus laevis provide an updated framework for UCP organization in ectothermic vertebrates. doi.org/10.1242/bio....

Polyploid origin and homoeology in X. laevis.

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Katharina Gritsch and colleagues present an alternative, seeding-based radial raytracing approach that is independent of image histograms and considers the PSF-blurred nature of imaged organelles. doi.org/10.1242/bio....

Effect of open-source deconvolution on resolution and contrast of LDs in WT and sei1Δ ldb16Δ cells. Raw data (Raw), 3D Gaussian-filtered data (Raw+Gauss) and deconvolved data (RL) of LDs in WT cells of MIPs of BODIPY-493/503-labeled LDs.

Nataliya Timoshevskaya and colleagues implicate histone and non-histone protein acetylation in the early transcriptional regulation of regeneration associated genes. doi.org/10.1242/bio....

Effect of A-485 on axolotl embryo tail regeneration. (A) Representative images of tail regeneration at 7 days post amputation (DPA) for 0.1% DMSO- and 15 μM A-485-treated embryos. The dashed yellow lines indicate the plane of amputation. (B) The amount of regenerated tail tissue at 7 DPA for embryos that were treated with 0.1% DMSO (N=11), 15 μM A-485 (N=10), and 20 μM A-485.