In Bar Harbor for the Jackson Lab cancer course and the views are stunning.

We took a deep dive to understand the hereditary component of a family unduly touched by glioblastoma and uncovered a new pathogenic variant. This may reflect a paradigm: highly pathogenic and rare variants may be responsible for familial glioma risk. www.medrxiv.org/content/10.6...

Germline Variants in Centromere Binding Protein 126 Predispose to Glioblastoma

Background Glioblastoma (GBM) is the most common primary malignant brain tumor in adults. While only 5% of GBM cases arise in a familial context, the genetic basis of familial GBM remains unresolved i...

medrxiv.org

Worst world cup of all time, ruined by FIFA’s greed.

At the Kansas City Oranje fanwalk, it seemed less than 10% were Dutch speaking, serving as an elegant reminder that the US is a country of immigrants.

Jumping on the bandwagon and am using Claude to create a 'Karpathy'-style person wiki/LLM. I wonder if it could help expedite manuscript and grant reviews.

We're finalizing the #BTM2026 scientific program and selecting the last short oral presentations. ⏳ Deadline extended: July 1 Join an exceptional international speaker line-up & help shape the discussion on brain tumors! 📍 Berlin | Oct 14–15, 2026 #NeuroOncology #BrainTumors

In our new collaborative paper on IDHmutant glioma with the Tirosh, Suva, Iavarone and Lasorella labs, we show how acquired genetic alterations converge with cell state changes and poor treatment responses. www.nature.com/articles/s41...

Acquired genetic and cell-state changes in IDH-mutant glioma progression - Nature

Longitudinal transcriptomic, chromatin and genomic analyses of the two types of IDH-mutant glioma reveal in detail how disease progression is influenced by interdependent genetic, epigenetic and micro...

nature.com

Excited to share our latest paper! We found that large pieces of the human genome can transfer between cells upon direct contact, endowing recipient cells with heritable phenotypic changes. @cp-cell.bsky.social (1/7) www.cell.com/cell/fulltex...

Genome instability triggers intercellular DNA transfer between human cells www.cell.com/cell/fulltex...

Genome instability triggers intercellular DNA transfer between human cells

Mammalian cells can pass damaged pieces of their genome directly to neighboring cells via contact-dependent, nanotube-like connections. These transferred DNA fragments persist and function, revealing ...

cell.com

The first funder to see the light, hopefully more will follow! news.cancerresearchuk.org/2026/04/01/w...

Why we won’t be funding open access publishing any more - Cancer Research UK - Cancer News

The open access movement was bold and promising, but ultimately disappointing. Now is the time to stop and call for a new way to make publishing work…

news.cancerresearchuk.org

Why, in 2026, do reviewers still have to browse all over the PDF to find figures and figure legends, rather than embedding them with the text. Journals (not the editors!) really do not care about reviewers and their time.

Interesting observation on a specific subset of H3-altered gliomas: DNA Methylation Profiling Reveals a Novel Subtype Harboring IDH Mutation in H3-altered Gliomas academic.oup.com/neuro-oncolo...

DNA Methylation Profiling Reveals a Novel Subtype Harboring IDH Mutation in H3-altered Gliomas

AbstractBackground. H3-altered gliomas, now recognized by WHO CNS5 as grade 4 neoplasms driven by histone H3 mutations (notably H3K27M and H3G34R/V), exhib

academic.oup.com

There is a lot of talk lately about multi-year funding (MYF) at NIH. This is mostly a paperwork issue, but it can have a dramatic impact on the number of grants that get funded. I was curious how this would impact grant numbers over time, so I did some simple modeling. 1/n

Raise your hand if you think that the new biosketch formatting will improve the ways NIH distributes extramural funding or funding transparency.

Having too much with the new wired birdfeeder and its AI powered bird recognition feature. Its a dark-eyed junco!

I can't believe this still needs to be said (and more loudly): Trans rights are human rights.

And here is your accompanying editorial: Leveraging Single-Cell Profiling in Early-Phase Trials to Guide Rational Therapy Development url: academic.oup.com/neuro-oncolo...

Leveraging Single-Cell Profiling in Early-Phase Trials to Guide Rational Therapy Development

Julia Louw, Jodie Jepson, Anna M Corcoran, Mustafa Khasraw; Leveraging Single-Cell Profiling in Early-Phase Trials to Guide Rational Therapy Development, N

academic.oup.com

Shwetal Mehta@shwetalm.bsky.social · 9mo ago

Very excited to have this collaborative work on evaluating PK/PD and single-cell responses for Ribociclib+Everolimus in #rGBM published. It was such a great experience working with @kevin-johnson.bsky.social and @roelverhaak.bsky.social. @ivycenter.bsky.social @anchitien.bsky.social

Happy to share a new #NORLUX study on how humanized patient-derived xenografts of #glioblastoma can be useful in investigating immunosuppression and clinically-relevant immunotherapy testing. See for more: www.biorxiv.org/content/10.1... #immunotherapy, #preclinicalmodeling,

It was a great pleasure to learn about a recent discovery in ecDNA biology that answers the most critical question on ecDNA maintenance! @nature.com Are you a non-scientist? No worries! My team wrote a lay-audience-friendly summary about this exciting research finding! Check it out! rdcu.be/eQMvM

Nature@nature.com · 9mo ago

Nature research paper: Genetic elements promote retention of extrachromosomal DNA in cancer cells go.nature.com/3JLvsSJ

Very excited to have this collaborative work on evaluating PK/PD and single-cell responses for Ribociclib+Everolimus in #rGBM published. It was such a great experience working with @kevin-johnson.bsky.social and @roelverhaak.bsky.social. @ivycenter.bsky.social @anchitien.bsky.social

Roel Verhaak@roelverhaak.bsky.social · 9mo ago

Delighted to share this new collaborative paper with the Ivy BTC where we performed deep characterization of glioma patients enrolled on a CDK4/6i Phase 0 trial academic.oup.com/neuro-oncolo... with @kevin-johnson.bsky.social @shwetalm.bsky.social @nadersanai.bsky.social

Delighted to share this new collaborative paper with the Ivy BTC where we performed deep characterization of glioma patients enrolled on a CDK4/6i Phase 0 trial academic.oup.com/neuro-oncolo... with @kevin-johnson.bsky.social @shwetalm.bsky.social @nadersanai.bsky.social

Single nucleus transcriptomics, pharmacokinetics, and pharmacodynamics of CDK4/6 and mTOR inhibition in a phase 0/1 trial of recurrent high-grade glioma

AbstractBackground. Outcomes for adult patients with high-grade glioma (HGG) remain poor, necessitating new treatment strategies. Key challenges include po

academic.oup.com

Sharks absolutely get cancer, and people claiming otherwise are pseudoscientific grifters preying on the desperate. Even if sharks did not get cancer, eating shark would not cure your cancer any more than eating LeBron James would make you better at basketball.

Senior Research Tech (Duke) – tumor immunobiology lab. Work with tumor/blood/CSF samples, culture patient-derived cell lines, assist single-cell assays, and support & lead research. Bio degree + research exp required. No visa sponsorship. Title may vary. Apply → careers.duke.edu/job-invite/2...

A new drug candidate for a difficult-to-treat type of lung cancer, developed by scientists in the Broad-Bayer oncology research alliance, targets HER2 mutations in lung cancer and shrinks tumors in mice and humans.

Broad-Bayer collaboration leads to drug candidate for a hard-to-treat type of lung cancer

The compound, now under priority review at FDA, targets HER2 mutations in lung cancer and shrinks tumors in mice and humans.

broadinstitute.org

The immunology of brain tumors | Science Immunology www.science.org/doi/10.1126/... Happy to share this review article by @lukasbunse.bsky.social, Theresa Bunse and I @platten-lab.bsky.social, Michael Kilian, Fran Quintana @quintanalabhms.bsky.social.

The immunology of brain tumors

The cellular and molecular determinants of the antigenicity of brain tumors and the immunosuppressive brain tumor microenvironment are reviewed.

science.org

Today’s lab meeting is a debate of recent Nature/Science retraction decisions: fair or not? Important lesson that not all retractions are the same, authors not always to blame.

Almost half way to our fundraising target - and only two weeks to go! I'll be riding the 100 mile #CloserToFreeRide to raise money to support cancer research and patient care. Please consider donating - every penny counts! ➡️ www.rideclosertofree.org/participants... #CTFRide @ctfride.bsky.social

A fundraising page for Sarah Aitken

Join the Closer to Free Ride on Saturday, September 6th. Register or donate at RideCloserToFree.org.

rideclosertofree.org

Sarah Aitken@s-j-aitken.bsky.social · last yr.

Together with friends and colleagues from #CMCO @yalecancer.bsky.social, @yalepathology.bsky.social, and further afield, we are the #CycloPaths Closer to Free Ride 🚲06 September 2025 💪100 miles #CTFRide Join our team, spread the word, sponsor us if you can www.rideclosertofree.org/participants...

Devastating news. The Pediatric Brain Tumor Consortium has lost its ability to apply for federal funding upon which it is structured. Without this, it cant exist. This threatens access to clinical trials for children. These children need MORE funding and MORE trials, not less. They deserve better

🔥 Hot of the press in Neuro-Oncology! 🧠 #Glioblastoma in Adults: A Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) Consensus Review on Current Management and Future Directions. academic.oup.com/neuro-oncolo... @eanoassociation.bsky.social @neuroonc.bsky.social

Glioblastoma in Adults: A Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) Consensus Review on Current Management and Future Directions

Abstract. Glioblastoma is the most common type of malignant primary brain tumor and a major cause of morbidity and mortality. In 2021 the World Health Orga

academic.oup.com

Findings from @roelverhaak.bsky.social et al. reveal lentiviral transduction + antibiotic selection dramatically ⬇️ ecDNA+ #cancer cells, revealing both a challenge for research and a potential therapeutic clue. #ecdna aacrjournals.org/cancerrescom... @aacrjournals.bsky.social