Genetic correlations of social behaviour with ADHD, MDD, autism and schizophrenia showed different developmental patterns, inferred from the social-behaviour GWAS. @luciadehoyos.bsky.social @mpi-nl.bsky.social @eagle-genetics.bsky.social @r2d2mh.bsky.social doi.org/10.1038/s415...

We introduced the concept of polygenic accuracy to evaluate how well polygenic scores detect social context. @luciadehoyos.bsky.social @mpi-nl.bsky.social @r2d2mh.bsky.social @eagle-genetics.bsky.social doi.org/10.1038/s415...

We identified six genomic regions associated with social behaviour, including signals within the CADM2 gene, and found evidence that genetic associations differed by context. doi.org/10.1038/s415... @luciadehoyos.bsky.social @mpi-nl.bsky.social @r2d2mh.bsky.social @eagle-genetics.bsky.social

Our new Nature Human Behaviour study uses genome-wide meta-regression across nearly 500,000 social-behavioural observations from more than 73,000 people aged 2–29. Genetic associations differed by behaviour, reporter and age. doi.org/10.1038/s415... @eagle-genetics.bsky.social @r2d2mh.bsky.social

Context matters: our new genome-wide meta-regression analysis of social behaviour Context (social domains, age, raters) is not noise! Very proud of our new work. Thank you to: @luciadehoyos.bsky.social @mpi-nl.bsky.social @eagle-genetics.bsky.social @r2d2mh.bsky.social doi.org/10.1038/s415...

Genome-wide analysis of social behaviour across social domains, reporters and developmental stages: a meta-regression approach - Nature Human Behaviour

A genome-wide meta-regression analysis of social behaviour studying ~500,000 observations from ~70,000 individuals, modelling context-specific SNP variation as explained by social domains, informants ...

doi.org

Our work on genetic links across infant motor behaviour, self-care/symbolic actions, and emerging language abilities has been published, with first author @everhoef.bsky.social ! doi.org/10.1111/jcpp... Developing language within a developing body! @mpi-nl.bsky.social

<em>Journal of Child Psychology and Psychiatry</em> | ACAMH Pediatric Journal | Wiley Online Library

Background Mastering gross motor abilities in early infancy and culturally defined actions (e.g. self-care routines) in late infancy can initiate cascading developmental changes that affect language...

doi.org

As part of our meta-regression GWAS (preprint doi.org/10.1101/2025...), our PGS predict variation in social context, across outcomes, informants, and, largely, developmental stages, allowing for contextual correlations screens, giving new insight into shared trajectories with mental health.

The strongest signal found within our social behaviour meta-regression GWAS (doi.org/10.1101/2025...) resided within the CADM2 gene, associated with self-reported (low) prosocial behaviour at ages 9-14 years.

Our genome-wide meta-regression of social behaviour is out as a preprint! www.biorxiv.org/content/10.1... Wonderful @eagle-genetics.bsky.social work with first author @luciadehoyos.bsky.social! We model and predict genetic variation according to social context: outcomes, informants and age!

We show that preschool musicality is related to school-age speech-related communication and is partially captured by PGS for rhythmicity. Without claiming causality, the identified links are directionally consistent with development and unrelated to cognition/proxies of EA.

It was such fun work @luciadehoyos.bsky.social, Ellen Verhoef, ‪@aysuo.bsky.social‬, Janne Vermeulen, Celeste Figaroa, @profsimonfisher.bsky.social, Reyna Gordon and @miriamlense.bsky.social‬! Thanks for your thoughts and contributions!

Just out: “Preschool musicality is associated with school-age communication abilities through genes related to rhythmicity.” doi.org/10.1038/s41539-025-00329-y Big thanks to the first author, amazing @luciadehoyos.bsky.social, and all our co-authors! @mpi-nl.bsky.social

Preschool musicality is associated with school-age communication abilities through genes related to rhythmicity - npj Science of Learning

npj Science of Learning - Preschool musicality is associated with school-age communication abilities through genes related to rhythmicity

doi.org

I am absolutely delighted to work together with @yanlinzhou.bsky.social at @mpi-nl.bsky.social as part of her MSCA award, extending collaborations with dieterwolke.bsky.social, @warwicklng.bsky.social and @R2D2mh. Congratulations on your award, Yanlin!

Warwick Lifecourse and Neonatal Group@warwicklng.bsky.social · 2y ago

@warwickpsych.bsky.social @WolkeDieter + bit.ly/WarwickLNG research group congratulate Dr Yanlin Zhou from the @R2d2Mh project, on an MSCA award with @bstpourcain at the Max Plank Institute of Psycholinguistics. Project: "Genomic and Environmental factors of Resilience to Early-life stress" 🎉

Million Veteran Program & FinnGen teams are pleased to release v1 meta-analysis of MVP, FinnGen and UKBB GWAS data. This first version includes ~300 binary disease definitions across >1.5 M individuals. Browse scans at: mvp-ukbb.finngen.fi

Please join us today for our recorded webinar at adhdeurope.eu "Deciphering genetic links between early language abilities & ADHD" at 15.00 CET! www.youtube.com/watch?v=YxT1... Ellen Verhoef and I will discuss our recently published @eagle-genetics.bsky.social work! tinyurl.com/yx5jht2y

Deciphering genetic links between early language abilities & ADHD

YouTube video by Broadcasting ADHD Europe

youtube.com

www.themarginalian.org/2014/03/28/d... I wish we could say this one day about peer review.

How to Criticize with Kindness: Philosopher Daniel Dennett on the Four Steps to Arguing Intelligently

“Just how charitable are you supposed to be when criticizing the views of an opponent?”

themarginalian.org

I am so proud of my PhD student @luciadehoyos.bsky.social at the Max Planck Institute for Psycholinguistics NL, who won the Outstanding Associate Member Oral Presentation Award #BGA2024 for her work on the social behaviour meta-GWAS in the @eagle-genetics.bsky.social consortium

Fancy working with us on the genetics (epigenetics) of early language development and social abilities? We have an open 4-year, fully funded PhD position starting 1 October 2024: www.mpi.nl/career-educa...

We are depositing the meta-GWAS summary statistics of early vocabulary size into The Language Archive (TLA) and hope they will spark future research. www.biologicalpsychiatryjournal.com/article/S000...   t.co/5f0SFNf0mb

Our SFARI-funded work “Structural models of genome-wide covariance identify multiple common dimensions in autism” is just out in Nat Commun! Congratulations to the first author @luciadehoyos.bsky.social, THANK YOU to all co-authors, participants and @simonsfoundation.org! tinyurl.com/yuy6465x

Our study identified genetic associations between children’s early vocabulary size and later-life ADHD, literacy, and general cognition. However, these associations changed dynamically across the first three years of life. tinyurl.com/bdzxbxv8

Wonderful news! Our work @MPI_NL showing that infant/toddler vocabulary size is genetically linked to ADHD, literacy, and cognition has been published in Biol Psychiatry tinyurl.com/bdzxbxv8 Big THANK YOU to #EAGLE_GENETICS co-authors & cohorts and first author Ellen Verhoef

We are looking for a new team member interested in ASD and quantitative genetics to join our group as part of the R2D2 project. We will combine analyses on social behaviour within the EAGLE consortium with studies of ASD in SPARK. Interested? Have a look here:

On my way to #WCPG2023; really looking forward to it!

Everytime I come back here my mind unfolds ... my mental garden

We have an upcoming PostDoc position in Statistical Genomics within my group at @MPI_NL as part of the EU-funded @R2d2Mh project. Interested in modelling the genomic influences underlying social behaviour in ASD? tinyurl.com/3w8k8ph7

Slowly diving into the deep blue sky. Glad to be on the other side and finding some familiar faces...