🎉 Carlos Moreno-Yruela ( @carlosmyruela.bsky.social ) has received an Accésit at the Premios Tercer Milenio 2026, recognizing excellence in science communication, research & innovation. Now launching his own lab at #IBEC with an ERC Starting Grant. 👏

🎉 ¡Orgullo RSEQ! Nuestros socios @casadevallcarla.bsky.social, @nikinikki87.bsky.social y @carlosmyruela.bsky.social han sido galardonados con una prestigiosa #ERCStartingGrant 2025🔬 Enhorabuena!!!!! 📖 rseq.org/tres-miembro... @urv.cat @lcbm-epfl.bsky.social @iciq.org @icfo.eu

Tres miembros de la RSEQ han conseguido una ERC... – RSEQ

Los miembros de la RSEQ: Carla Casadevall, Nicoletta Liguori y Carlos Moreno Yruela consiguen una ERC Starting Grant en la convocatoria 2025.

rseq.org

I am really excited that #CHEMTUBIO will be funded through an @erc.europa.eu Starting Grant! This funding will kickstart my lab next year and help us unveil the mechanisms and therapeutic implications of erasers of microtubule modifications. Stay tuned!

European Research Council (ERC)@erc.europa.eu · 12mo ago

📣 The ERC Starting Grant call results are out! Find out which early-career researchers will receive funding this year, what they will be investigating, where they will be based... plus lots of other #ERCStG facts & figures for 2025! ➡️ buff.ly/IsafuFh #FrontierResearch 🇪🇺#EUfunded #HorizonEurope

Six #BISTcommunity early-career researchers have secured prestigious ERC grants 👏 These awards highlight the ability of BIST Community centres to attract and nurture outstanding young international talent. @crg.eu @icfo.eu @iciq.org @ibecbarcelona.eu 👉http://bit.ly/486ENOq

Pint of Science was again a great success in Lausanne, with >500 people attending our events! Kudos to co-coordinators @miriamlisci.bsky.social and @juliensluneau.bsky.social, and to the fantastic team of 19 volunteers at the bars 🥳! #PINT25 #scicomm

If you always wanted to know the kinetics of how the Polycomb enzymes modify chromatin, we are thrilled to share our work!!! 🎉📄🧬🔬 Thank you, @beatfierz.bsky.social for all the guidance as well as the @lcbm-epfl.bsky.social group members for all the support! doi.org/10.1126/scia...

Single-molecule analysis reveals the mechanism of chromatin ubiquitylation by variant PRC1 complexes

Single-molecule experiments show that active conformation formation controls chromatin ubiquitylation kinetics by variant PRC1.

doi.org

Check out our new study of chromatin ubiquitylation. @alexateslenko.bsky.social visualized directly at single molecule scale how vPRC1 ubiquitylates neighboring nucleosomes. These results suggest potential mechanism on how H2Aub domains are established. 👇👇👇 www.science.org/doi/10.1126/...

Single-molecule analysis reveals the mechanism of chromatin ubiquitylation by variant PRC1 complexes

Single-molecule experiments show that active conformation formation controls chromatin ubiquitylation kinetics by variant PRC1.

science.org

The program for Pint of Science Lausanne 🧪 is ready! pintofscience.ch/events/lausa... This year we have again three venues covering topics from aging to robotic surgery or sustainable agriculture Come join us on the 19th, 20th and 21st of May 🥳 #PintCH #scicomm @pintofscience.ch

Lausanne

Explore Pint of Science Switzerland events in Lausanne

pintofscience.ch

Very happy to see this story out in #JACS_Au! Discovery of De Novo Macrocycle Inhibitors of Histone Deacetylase 11 pubs.acs.org/doi/10.1021/... #ChemBio #chemsky #HDAC

Discovery of De Novo Macrocycle Inhibitors of Histone Deacetylase 11

Histone deacetylase (HDAC) enzymes are epigenetic regulators that affect diverse protein function by removing acyl groups from lysine side chains throughout the proteome. The most recently discovered ...

pubs.acs.org

!THREE OPPORTUNITIES TO JOIN US! We are looking for 3 (!!!) PhD students interested in: How Metabolism affects Genome Regulation. Join us at @carrerasijc.bsky.social as Marie Sklodowska Curie network fellow. More info: 2 x experimental: www.nuclear-dn.eu 1 x computational: www.hubmol.eu

🚨 Excited to share our work @elife.bsky.social doi.org/10.7554/eLife.98827.2 on targeting Hepatitis B virus #HBV 🦠 capsid aggregation by designed molecules! #DrugDiscovery #ChemBio Thanks V Khayenko C Makbul @clemensschulte.bsky.social & @boettchercryoem.bsky.social for stunning #CryoEM visuals!

Bettina Böttcher@boettchercryoem.bsky.social · 2y ago

Our joined effort with the the Maric Lab @hmariclab.bsky.social @uniwuerzburg.bsky.social on how to aggregate capsids of Hepatitis B virus inside cells is now out in Elife doi.org/10.7554/eLif... . #cryoEM 🧪❄️🔬

#SIRT7 is a histone deacetylase with highly specific activity on #chromatin substrates. We just published mechanism-based #cryoEM structures of #SIRT7 on nucleosomes to understand its activity 👇 www.nature.com/articles/s41... (1/8) #ChemBio #ChemSky

Cryogenic Electron Microscopy: MagIC beads for scarce macromolecules. #CryoEm https://elifesciences.org/articles/105335?utm_source=bluesky&utm_medium=social&utm_campaign=organic_insights

Welcome immigrants from X interested in science to the friendlier skies of @bsky.app, as documented by a new @nature.com survey (but you already knew that 😉) "Bluesky is much better for science. There is much less toxicity, misinformation, and distractions." www.nature.com/articles/d41...

Roughly 6,000 readers answered our poll, with many declaring that Bluesky was nicer, kinder and less antagonistic to science than X https://go.nature.com/42tH8Ai

Bluesky’s science takeover: 70% of Nature poll respondents use platform

Roughly 6,000 readers answered our poll, with many declaring that Bluesky was nicer, kinder and less antagonistic to science than X.

go.nature.com

A nice commentary article by @carlosmyruela.bsky.social y.social and @beatfierz.bsky.social has been already published! Thank you, Carlos and Beat! elifesciences.org/articles/105...

Cryogenic Electron Microscopy: MagIC beads for scarce macromolecules

Specialized magnetic beads that bind target proteins to a cryogenic electron microscopy grid make it possible to study the structure of protein complexes from dilute samples.

elifesciences.org

Here is our most recent reviewed preprint on MagIC-cryo-EM invented by @yarimura.bsky.social elifesciences.org/reviewed-pre... Please note that this is not the final version, or VOR. A revised version (www.biorxiv.org/content/10.1...) is currently being reviewed at eLife.

Happy to share the latest preprint from my PhD studies on the discovery of de novo macrocyclic inhibitors of HDAC11. This was a great collaboration between @christianaolsen.bsky.social lab (@carlosmyruela.bsky.social, @tnhansen.bsky.social) and Christian Heinis lab (@alexanderln.bsky.social).

Christian A. Olsen@christianaolsen.bsky.social · 2y ago

New preprint @chemrxiv.bsky.social on discovery of macrocyclic inhibitors of HDAC11 with the Christian Heinis #EPFL Main contributors @danieladankova.bsky.social, @alexanderln.bsky.social, @carlosmyruela.bsky.social 🙏 @ERC_Research, @novonordiskfond, @DFF_raad for 💶 chemrxiv.org/engage/chemr...

New preprint @chemrxiv.bsky.social on discovery of macrocyclic inhibitors of HDAC11 with the Christian Heinis #EPFL Main contributors @danieladankova.bsky.social, @alexanderln.bsky.social, @carlosmyruela.bsky.social 🙏 @ERC_Research, @novonordiskfond, @DFF_raad for 💶 chemrxiv.org/engage/chemr...

Happy to share a fun collaboration between EPFL and UCPH initiated by @carlosmyruela.bsky.social, Christian Heinis, @christianaolsen.bsky.social and I! Big shout-out to @danieladankova.bsky.social who spearheaded the project. Now out on @chemrxiv.bsky.social chemrxiv.org/engage/chemr...

Discovery of de novo Macrocycle Inhibitors of Histone Deacetylase 11

Histone deacetylase (HDAC) enzymes are epigenetic regulators that affect diverse protein function by removing acyl groups from lysine side chains throughout the proteome. The most recently discovered ...

chemrxiv.org

We’re no experts but this sounds like it might be suboptimal for disseminating research.

Judd Legum@juddlegum.bsky.social · 2y ago

Elon admits that any post on X with a link is throttled He advises you to upload content directly to X instead, where he can monetize it Musk is the richest person in the world and his view is everyone should work for him for free

We are working on the program for the 5th Virtual ChemBioTalks on September 30th, 2025. While we already have commitments by our keynotes @oconnorlab.bsky.social and @craigmcrews.bsky.social, the remaining program is still in planning. Whom would you most like to hear at our next event?

📯📯 Chemical Biology starter pack 📯📯 140 PIs & groups posting primary research in chemical biology. Please reskeet (?) & reply to this post if you want to be added! go.bsky.app/KLrTWoj Let's make ChemBioSky even greater again! #realtimechem #FluorescenceFriday #chemsky #chemtwitter #AgentOrange

Btw check out our collaborative effort with the Walter Lab to map nucleosome acidic patch interactors for all nuclear proteins: predictomes.org/view/acidicp...

Predictomes | H. sapiens H2A/H2B vs. nuclear proteome

A free interactive resource for viewing predicted AlphaFold multimer structures for protein pairs in biological pathways.

predictomes.org

If you're seeing "Invalid Handle" on your profile, this should resolve on its own — thanks for your patience!! 🦋

Are you looking for a PhD position in peptide synthesis, automation, and computational analysis? 🧪 💊💻 We have an open position for a collaborative PhD thesis (with Novo Nordisk). For more details, please see: jobs.uzh.ch/job-vacancie... ⏰ Application deadline = November 15

UZH: PhD Position in Solid-Phase Peptide Synthesis (Industry Collaboration)

A PhD position is available in the group of Prof. Dr. Nina Hartrampf at the Department of Chemistry, University of Zurich (Switzerland), in collaboration with the company Novo Nordisk in Måløv, Denmar...

jobs.uzh.ch

The mammalian Zn-dependent #HDACs are very diverse. They target various acyl-lysine modifications and acetylation of polyamines and other molecules. This study led by Michael Lammers and Leonie Graf (Uni Greifswald) trace these features in bacteria🦠! t.co/LGfZ5Esmo5 1/6

Inhibitors of histone deacetylases (#HDACs) have longer and longer on-target residence times, which may help future clinical applications. How is this achieved? Check out our new #OpenAccess Perspective in JACS_Au, with Yasir Raouf, to know more! 👇🏻 pubs.acs.org/doi/10.1021/...

Slow-Binding and Covalent HDAC Inhibition: A New Paradigm?

The dysregulated post-translational modification of proteins is an established hallmark of human disease. Through Zn2+-dependent hydrolysis of acyl-lysine modifications, histone deacetylases (HDACs) a...

pubs.acs.org

Another piece of the histone lactylation puzzle falls into place: Lysine L-lactylation is the dominant lactylation isomer induced by glycolysis nature.com/articles/s41589-024-01680-8# #lactate #chembio

Lysine l-lactylation is the dominant lactylation isomer induced by glycolysis - Nature Chemical Biology

Using a combination of antibody- and LC–MS/MS-based methods, Zhang et al. reveal lysine l-lactylation as the key lactylation isomer in cellular histones, responding dynamically to glycolysis and posit...

nature.com

Imbuing peptide libraries with drug-likeness: rdcu.be/dxxCi Nice News&Views article by Sunit Pal and Peter ‘t Hart!