We are recruiting a PhD student 🥼🙋 Topic: how germ cells bend gene expression dogmas Fly genetics + proteomics + genomics. Fully funded. Aarhus University 🇩🇰 info on the project and how to apply👇 mbg.au.dk/en/peter-and... I'd really appreciate it if you'd help spread the word. Thanks

New preprint in collaboration with the Capelson lab. Roles for nucleoporin paralogs.

bioRxiv Developmental Biology@biorxiv-devbio.bsky.social · last wk.

Distinct functions of Nup93 paralogs in tumor growth and Polycomb-mediated repression of JAK/STAT signaling https://www.biorxiv.org/content/10.64898/2026.08.28.747911v1

Insights into longevity & virus-driven adaptation from Myotis bat genomes International & fantastic collab. with @psudmant.bsky.social @denard.bsky.social Labs ! Major credit to the 2 leading scientists: Juan Vazquez & @lauterbur.bsky.social now with their own labs! You 2 rock! (1/n)

Insights into longevity and virus-driven adaptation from Myotis bat genomes - Nature

Comparative and functional analyses of Myotis bats uncover unique patterns of adaptation in virus-interacting proteins and longevity-associated pathways, linking two hallmarks of bat biology.

nature.com

CIRI Lyon@ciri-lyon.bsky.social · 2w ago

Félicitations à Lucie Etienne et son équipe, soutenue par le CNRS IRP RAPIDvBAT, le CNRS IRC Univ. Arizona et le CNRS MITI, pour leurs travaux sur la longévité et l’adaptation induite par les virus à partir des génomes de chauves-souris Myotis. 💡: www.nature.com/articles/s41....

We watched piRNAs and transposons across development, saw them dance tightly and wrote a paper about it. It's so cool to see it online and we will make a thread about it all very soon. Stay tuned :-)

bioRxiv Genetics@biorxiv-genetic.bsky.social · 2w ago

A developmental switch in the piRNA pathway ensures stage-specific transposon silencing https://www.biorxiv.org/content/10.64898/2026.08.28.747770v1

Open your lab here at Utah! utah.peopleadmin.com/postings/208...

MxA is one of the broadest antiviral proteins mammals make. It’s a big reason most bird flu strains never get a foothold in people. The rare ones that succeed have learned to dodge it. How MxA actually recognizes viral targets at the molecular level is unknown for a bunch of technical reasons.

Terrific opportunity! Damian is a wonderful mentor with an exceptionally creative and compelling research program.

Damian Dudka@damiandudka.bsky.social · 2mo ago

My lab just opened at Lehigh University - we study the origins, mechanisms, and impacts of the rapid evolution of the chromosome segregation machinery. I'm looking for 2 team members (postdoc and lab tech) who are passionate about evolution and cell division! See the opportunities at dudkalab.me.

🚨NEW PAPER 🚨 "Deconstructing empirical fitness seascapes across scales of granularity" published in #G3 (@genetics-gsa.bsky.social) 1/2 The fitness landscape has been among the most influential instruments in evolutionary theory for nearly a century. But we often treat them as fixed and static.

CRISPR-mediated centromere fission generates neochromosomes with distorted meiotic inheritance in Arabidopsis biorxiv.org/content/10.6... new preprint from us - includes changing the Arabidopsis karyotype from 5 -> 6 chromosomes using Cas9 & outcomes of 5/6 chromosome hybrid meiosis

mtDNA deletions cause incurable diseases. Our CRISPR screen found a fix: deleting MTERF1 restores mitochondrial function, not by clearing bad genomes, but by making the healthy ones work harder. Simple Biology! New preprint 👇 @tatakavlashvili.bsky.social www.biorxiv.org/content/10.6...

MTERF1 loss buffers against pathogenic mtDNA deletions through transcriptional regulation

Large-scale mitochondrial DNA (mtDNA) deletions cripple oxidative phosphorylation once they exceed a critical heteroplasmy threshold, causing incurable mitochondrial pathologies. Using a genome-wide C...

biorxiv.org

Hello World ! We have another postdoc position open in the lab! Are you a freshly minted Ph.D. with a passion for chromatin and evolution ? Come join our ERC project #EvoEpi ! Inclusive environment + cool people + great science = success details 👉 tinyurl.com/3r6zk54n Repost are always appreciated

How do transposons jump when they’re released from host control? I babysat two chromosomes for 2 years, making sure they are ok without most piRNAs. Here’s what we found & excited to share my 1st postdoc paper: “piRNA loss unleashes episodic transposition bursts” www.biorxiv.org/content/10.6...

piRNA loss unleashes episodic transposition bursts

In Metazoa, transposon expression is suppressed by the piRNA pathway, and disruption of this pathway leads to rampant transposon expression. However, it remains unclear whether increased transposon ex...

biorxiv.org

I know it seems like a heretical idea, but one way to figure out if a preprint is really interesting (to you) is... to read the preprint. Then, in the spirit of sharing, send a note to authors: a simple kudos or a more detailed question. I do this a dozen times a year. It's awesome. Try it.

After some good funding news, we are hiring! Looking for a postdoc to join our team and lead our explorations into transposon repression by the nuclear lamina. Check out the full ad on our lab website at buchwalter-lab.github.io/postdoc-ad.pdf + contact me to learn more!

1/n Check out our new paper, spearheaded by @fborne.bsky.social, just out in PLoS Genetics doi.org/10.1371/jour....

Epistasis among clustered lineage-specific amino acid substitutions in the Drosophila Trio protein

Author summary Proteins fold into three-dimensional structures that are essential for their function. Because these structures depend on interactions among amino acids, the fitness effect of a mutatio...

doi.org

#SMBE2026 S24: Molecular mechanisms of selfish elements and strategies 🗓️ Mon Jun 29, 10:20am 🔗 smbe2026.org/programme Talks by: @levine-lab.bsky.social Yu Hua @cecilecourret.bsky.social @eleanoreritter.bsky.social Elli Cryan @alexand-kwak.bsky.social Steve Perlman @antisense.bsky.social

Exciting new work from the lab led by @lagiven.bsky.social & co-advised by @tododge.bsky.social mapping pigmentation variation in the swordtail X. nezahualcoyotl! Spotting variation is linked to xmrk but embedded in complex genomic regions that Tris & Lyle tackled with UL nanopore: shorturl.at/Ljw1z

Two melanic pigment patterns are associated with a sex chromosome-linked oncogene in the mountain swordtail Xiphophorus nezahualcoyotl

Sex-linked traits are widespread, but their genetic architecture has been challenging to characterize, due in part to the repetitive and structurally complex nature of sex chromosomes. In swordtails a...

shorturl.at

Very happy to announce a big new paper from the lab, led by grad students @smishra677.bsky.social and Laia Pomar-Pallarès (in collaboration with @roblanfear.bsky.social). We introduce a new way to study introgression, with accompanying software (DAFT) 1/n 🧵 www.biorxiv.org/content/10.6...

📣 POSTDOC position available in the Feschotte Lab at Cornell to work on #TRANSPOSONS! More details below. Pls send informal application or inquiry ASAP by DM or email to cf458_at_cornell.edu. Pls spread the word 🙏 #TEsky www.thefeschottelabatcornell.com

🧬 New research from the Burga lab! We took a closer look at a rogue selfish protein and caught evolution in the act of turning something old into something radically new 💡 (a.k.a. neofunctionalization) @imbavienna.bsky.social www.biorxiv.org/content/10.6... Curious? Here’s a breakdown:

Host-transposable element coexistence: a matter of resistance, tolerance and trade-off Read this new review by Séverine Chambeyron, Charlotte Grimaud, Mikiko Siomi et al link.springer.com/article/10.1...

👀"These results establish that naturally occurring copy-number variation within repetitive pericentromeric DNA is not merely noise, but a functional source of variation in chromosome segregation and gene regulation."

bioRxiv Genetics@biorxiv-genetic.bsky.social · 4mo ago

Pericentromeric repeat copy number tunes heterochromatin dosage to control chromosome segregation and gene expression in fission yeast https://www.biorxiv.org/content/10.64898/2026.05.08.723760v1

👋 Transposon lovers: registration is now open for the CSHL TE meeting! We have a 🔥 lineup of invited speakers and many slots for short talks selected upon abstract across all areas of TE biology. 🧬➰🧬 #TEsky Abstract deadline: July 10 meetings.cshl.edu/meetings.asp...

I'm looking to hire a postdoc. Please share if you can!

Did you know that many organisms delete parts of their genome during development? To know more please join us at the Roscoff meeting on "Mechanistic and Evolutionary Basis of Programmed DNA Elimination" Sep21- 25, 2026. Please share!
cjm.sb-roscoff.fr/en/conferenc...

Please share widely! We will imminently be posting a technician position in our lab group since @rheasood.bsky.social is off to grad school 🙌! If you know of anyone excited about molecular biology, evolution, and functional genomics please have them reach out (schumer at stanford). Start date ~June

Love Drosophila genetics — this journal club was a great way to share that enthusiasm and pay tribute to the pioneers of transposons regulation 🪰 How classical genetics uncovered key determinants of TE silencing #transposon @igred.fr @igred.fr 👇👇

Nature Reviews Genetics@natrevgenet.nature.com · 6mo ago

New online! How classical genetics uncovered key determinants of TE silencing

Our latest publication is now out at Genome Biology! link.springer.com/article/10.1... We uncover a unique association between a H3K27me3 reader complex and active transcription. A thread with our key findings: (1/8) #TEsky #Polycomb #transcription #smallRNAs

A H3K27me3 reader complex couples H3K27me3 accumulation to nascent transcription of transposable elements in Paramecium - Genome Biology

Background The ability to deposit histone H3K27-trimethyl (me3) marks is essential for transcriptional repression by Polycomb Repressive Complex 2 (PRC2). This is largely attributed to Polycomb repres...

link.springer.com

Germ cells have their own versions of core transcription factors and fertility depends on them. We're hiring a PhD student to figure out how! 📢 Fly genetics + proteomics + genomics. Fully funded. Aarhus University 🇩🇰 Deadline May 1 👇 Please share with anyone who might be interested!

The special issue Functional and Adaptive Effects of Genomic Structural Variation is now out in Heredity. Many thanks to all contributors for their submissions, to the editorial team at @heredityjournal.bsky.social and to @ellenleffler.bsky.social, @mydennis.bsky.social & @gokcumenlab.bsky.social!

Special Issue: Functional and Adaptive Effects of Genomic Structural Variation

See more information on the new Heredity special issue on functional and adaptive effects of genomic structural variation.

nature.com