Balancing phenotyping depth and representativeness in psychiatric genomics - Nature Genetics

Deep phenotyping can improve diagnostic precision in psychiatric genomics, but it remains susceptible to non-random, partly heritable selection bias that compromises representativeness. Accordingly, a...

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Genetic factor analysis for characterizing phenome-wide patterns of genetic pleiotropy - Nature Genetics

Genetic factor analysis uses genome-wide association summary statistics to identify shared polygenic factors underlying patterns of cross-trait genetic associations, while automatically determining th...

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Gb3 encodes a unique kinase fusion protein conferring greenbug resistance in wheat - Nature Genetics

Gb3 encodes an intracellular kinase–pseudokinase protein with a unique MAP3K-like domain that confers resistance to multiple greenbug biotypes in wheat.

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Single-nucleus atlas of cell-type specific genetic regulation in the human brain - Nature Genetics

Multi-resolution genetic regulatory atlas of the human brain from single-nucleus transcriptomics of 1,384 donors of diverse ancestries reveals cell type-specific regulation underlying genetic risk of ...

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Interpreting human genetic variation at atomic resolution - Nature Genetics

This Perspective discusses computational structural genomics, a conceptual framework that links genetic variants to three-dimensional molecular structures and their dynamics and function in a cellular...

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Genetic landscape of an in vivo protein interactome - Nature Genetics

This study uses budding yeast as a model system to link genetic variants with quantitative changes in protein–protein interaction strength under different environmental perturbations by leveraging a p...

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Pan-genome-based resequencing of 2,320 accessions reveals structural variations and accelerates breeding advances in cultivated peanut - Nature Genetics

Pan-genome analyses of cultivated peanut using 10 newly assembled genomes, along with whole-genome resequencing of 2,320 germplasm accessions, highlight structural variations and loci associated with ...

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Type 1 interferon perturbates clonal competition by reshaping human blood development - Nature Genetics

Single-cell multiomics of blood stem cells from patients with myeloproliferative neoplasms revealed that interferon-α normalizes blood counts by augmenting lymphoid differentiation and modulates clona...

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Contribution of copy number variants to schizophrenia in East Asian populations - Nature Genetics

Genomic analyses in populations of East Asian ancestry identify rare copy number variants associated with schizophrenia. Meta-analyses with populations of European ancestry identify additional risk lo...

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Cohesin prevents local mixing of condensed euchromatic domains in living human cells - Nature Genetics

Single-nucleosome imaging/tracking and super-resolution three-dimensional structured illumination microscopy within euchromatic regions show that cohesin-mediated loops constrain condensed euchromatic...

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Genome-wide association analyses of gestational phenotypes identify context-specific genetic effects - Nature Genetics

Genome-wide analyses in up to 121,579 pregnant women from China identify genetic associations across 111 phenotypes, including gestation-specific effects and interactions with gestational timing.

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Intrinsically disordered regions restrain genomic targeting of RNA and histone demethylases in mammals and plants - Nature Genetics

Intrinsically disordered regions impose regulatory restraints on gene-activating demethylases, limiting chromatin engagement and preserving genomic stability. This function is a key determinant of the...

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Pangenome-resolved structural variation drives adaptation and trait evolution in cucumber - Nature Genetics

Pangenome analyses of chromosome-scale genome assemblies for 125 diverse cucumber accessions highlight structural variation shaped by selection for geographical adaptation, fruit-length diversificatio...

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SUMOylation enhances DNMT1 function to repress mega-intergenic RNAs and viral mimicry - Nature Genetics

This study uses a highly selective inhibitor to elucidate DNMT1’s specific functions and their regulation. Notably, RFN4-mediated SUMOylation enhances DNMT1 mobility and DNA methylation, thereby promo...

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Promoter strength and position govern promoter competition through transcript-dependent insulation - Nature Genetics

By inserting diverse promoters at the mouse Sox2 locus, Koska et al. show that promoter strength, position and transcript length tune promoter competition through transcription-dependent insulation, i...

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Genome-wide association analyses of borderline personality disorder identify 11 loci and highlight shared risk with mental and somatic disorders - Nature Genetics

Genome-wide association analyses identify risk variants for borderline personality disorder and find genetic correlations with psychiatric disorders, behavioral traits and somatic diseases.

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Pioneer transcription factors direct tissue-specific cohesin chromatin entry and three-dimensional genome organization - Nature Genetics

Analyses in prostate cancer cell lines show that FOXA1 mediates tissue-specific recruitment of NIPBL to chromatin to orchestrate three-dimensional genome organization, acting in concert with ETS1 and ...

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The genomic position of an enhancer modulates bursting dynamics of the cognate promoter - Nature Genetics

We show that, in a genomic locus with minimal complexity, the distance between promoter and enhancer modulates the frequency of clustered transcriptional bursts. Thus, besides the nucleotide sequence,...

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Longitudinal changes in DNA methylation in IDH-mutant glioma fuel disease progression through altered cell state differentiation - Nature Genetics

The authors use single-cell multi-omics to interrogate longitudinal samples of isocitrate dehydrogenase mutant gliomas. Their analyses couple progression and hypomethylation with changes in differenti...

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A progeria syndrome links DNA hypermethylation to age-related pathology - Nature Genetics

This study investigates the consequences of hypermethylation in a progeria syndrome caused by gain-of-function DNMT3A mutations, finding effects on adult stem cell function.

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Multiscale analysis and functional validation of the cellular and genetic determinants of skeletal disease - Nature Genetics

The study integrates cross-species single-cell and genomic analyses with functional validations to map the endosteal bone compartment, revealing musculoskeletal-disease-relevant cell types and transcr...

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Enhancer control of promoter activity and variability via frequency modulation of clustered transcriptional bursts - Nature Genetics

Tünnermann et al. use live-cell imaging to study promoter activity under the control of an enhancer inserted at different genomic distances. RNA production from the promoter occurs in clusters of tran...

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Associate or Senior Editor, Nature Genetics

Job Title: Associate or Senior Editor, Nature Genetics Location: Shanghai, Beijing, Madrid, Milan or Pune, Hybrid Working Model Application Deadline: Aug 3rd, 2026 About Springer Nature Springer Natur...

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Interpretable, flexible and spatially aware integration of multiple spatial transcriptomics datasets from diverse sources - Nature Genetics

INSPIRE addresses challenges to integrating diverse spatial transcriptomics datasets by combining deep learning with non-negative matrix factorization, revealing shared and context-specific spatial ge...

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Tumor DNA methylation subtypes predict immunotherapy outcomes in pleural mesothelioma patients in the NIBIT-EPI-MESO study - Nature Genetics

Profiling of pleural mesothelioma samples from 91 patients identifies four DNA methylation subtypes that correlate with response to immune checkpoint inhibition and survival

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Genomic analyses implicate hormonal and metabolic dysregulation in polycystic ovary syndrome - Nature Genetics

Genome-wide analyses identify genetic loci and plasma proteins associated with polycystic ovary syndrome (PCOS). This study highlights the hormonal and metabolic foundations of the disease and explore...

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Three-dimensional genome reorganization foreshadows zygotic genome activation in Drosophila - Nature Genetics

Pico-C, a low-input Micro-C approach, reveals that dynamic three-dimensional genome folding precedes zygotic genome activation in Drosophila.

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