Translational science doesn’t just need newer models—it needs the comparative pathology expertise to interpret them correctly... Read the latest here: https://doi.org/10.1242/dmm.053172

Robust biomedical research requires rigorous Genetic Quality Control. Learn how the MMRRC’s process validates alleles and characterizes genetic backgrounds to ensure the highest level of reproducibility in your experiments. 🔬 Watch the introductory webinar here: https://youtu.be/23ypdpILgok?si=h

Dr. Stanley Gartler’s life was defined by unwavering integrity, analytical precision, and a profound commitment to scientific truth. His legacy lives on in every laboratory that values experimental reproducibility and curiosity-driven research. https://www.gs.washington.edu/stanley-gartler/

A lot to look out for at BIO! From the regional pavilions (from Italy to Ohio), talks on NAM validation and function, and help with mouse model ideas (even finding the right mouse with the MMRRC!). Stop by booth 4121. https://convention.bio.org/landing

All about the connection...The MMRRC has a great methbod to eliminate guesswork in experimental design via the Strain GQC Report to map genomic variations and find improved information from model selection. Read More Here: https://www.science.org/doi/10.1126/science.aec3177

Allele in a day's work: A new MMRRC paper delivers a framework to optimize design and elevate reporting in mouse models. 🔬 Far from focusing on flawed models, the work is about supporting researchers and improving scientific rigor. 🔗 https://www.science.org/doi/10.1126/science.aec3177

We are quite happy for Dr. Franklin on all his achievements, his mentorship, and his help with research the world over! For more info visit: https://cvm.missouri.edu/craig-franklin-receives-james-russell-lindsey-distinguished-lectureship-award/

Who knew the YAK could hold the secret to healing the human brain? (Hint - gene is Retsat) Source: https://www.the-scientist.com/a-genetic-mutation-found-in-yaks-boosts-myelin-repair-74204

A new Scn8a R1872W mouse model is paving the way for CRISPR-based epilepsy treatments. Source: https://www.jci.org/articles/view/196402

New research explores a promising, low-toxicity transplant strategy for diabetes. Learn more: https://www.jci.org/articles/view/201105#SEC7 And to view diabetic specific models, visit: https://www.mmrrc.org/catalog/StrainCatalogSearchForm.php?search_query=DOID:9352

When global competitors are accelerating their investments in biomedical research, America cannot afford to fall behind...https://www.fiercebiotech.com/research/despite-delays-nih-grants-generated-250-return-366b-investment-2025-report?utm_medium=email&utm_source=nl&utm_campaign=LS-NL-FierceP

Advances in organ and computer models are raising the prospect that some animal experiments could be eliminated. But there are still huge hurdles to overcome. Read More Here: https://postly.click/5vU

The research landscape is approaching a turning point. Proposed cuts would weaken science—especially physiology—that drives medical breakthroughs. This overview sets the stage for a deeper look at what’s at stake and why this full report matters: https://www.physio

Scientists, with initial mouse models findings, expand results in organoids to confirm nerve-repair treatment can trigger healing in human spinal tissue. Source: https://www.sciencealert.com/scientists-grew-mini-human-spinal-cords-then-made-them-repair-after-injury

🫱A new polymer delivery system may allow insulin to be absorbed through the skin and control blood sugar without injections, at least in animal studies! Source: https://www.nature.com/articles/s41586-025-09729-x

In vivo & in silico: Compounds linked to traditional medicine reduced anxiety-, depression-, and pain-related behaviors in mice. Computer modeling suggested key compounds and targets, while mouse studies showed how those predictions played out biologically: https://doi.org/10.100

Turning Back Immune System Aging: A new method instructs liver to pump out specific proteins, effectively hitting the "reset" button on an aging immune system to restore youthful defense capabilities. Source: www.livescience.com/health/immun...

📖 To celebrate the holidays, we've taken some of our strains to compose a seasonal story. Written version is below. Or spoken version here: youtu.be/xl-pHB0Y5bc . For the full "cast" see this link: postly.click/s61

National Security Commission on Emerging Biotechnology warns U.S. science is getting outpaced: https://www.fiercebiotech.com/biotech/us-commission-recommends-federal-research-revamp-avoid-losing-global-biotech-edge?utm_medium=email&utm_source=nl&utm_campaign=LS-NL-FierceBiotechResearch&oly_enc

Scientists found that HSL not only breaks down fat but also works inside the nucleus of to keep adipose tissue healthy, explaining why people lacking HSL lose fat instead of becoming obese. https://scitechdaily.com/obesity-discovery-

The research landscape is approaching a turning point. Proposed cuts would weaken science—especially physiology—that drives medical breakthroughs. This overview sets the stage for a deeper look at what’s at stake and why this full report matters: https://www.physio

The FDA has approved Kygevvi (doxecitine + doxribtimine) as the first-ever treatment for Thymidine Kinase 2 Deficiency (TK2d), offering hope to patients with this devastating mitochondrial disease. https://www.fda.gov/drugs/news-events-human-drugs/fda-approves-1st-

Scientists have made major progress in understanding and treating thymidine kinase 2 deficiency (TK2d), a rare genetic disorder that weakens muscles by disrupting mitochondrial DNA maintenance. https://postly.click/ABY

James D. Watson, part of the team that uncovered the double-helix structure of DNA in 1953 with Francis Crick, Rosalind Franklin and Maurice Wilkins, has died at 97. His work marked a notable moment in biology. https://www.yahoo.com/news/articles/james-watson-co-discoverer-double-1957www.yahoo.com/n

As oocytes grow, H2A.Z shifts from marking active genes to spreading across broader, silent DNA regions, working hand-in-hand with another modification to support healthy meiosis and prepare the egg’s epigenetic blueprint for early embryonic life. .nature.com/articles/s41594-025-01573-xMore Info:

IMPC Strategic Conference ‘Insights from the Past, Shaping the Future’ Program and key information 👉 https://www.mousephenotype.org/news/2025-virtual-impc-conference-registration-and-agenda/ Free Registration 👉https://tinyurl.com/yz7znkde

🎉 Big congrats to Dr. Eric Green for receiving the American Society of Human Genetics Leadership Award — a standing ovation for visionary leadership in genomics! Read About it here: https://www.genengnews.com/topics/omics/eric-green-receives-ashg-leadership-award-to-standing-ovation/

"Animal models provide insights that alternative approaches can’t. A heated debate about which method is better is distracting researchers from doing good science." https://EcKc5wILd4%3D

MMRRC is in Boston at ASHG for the next 3 days - booth 1327! For more info: https://meetings.ashg.org/event/ASHG25/program/schedule

What Baby KJ’s CRISPR Breakthrough Really Tells Us. Reflections on the balance between hope and realism — new therapies are exciting, but they’re not universal cures yet. Read More: https://www.statnews.com/2025/10/09/crispr-cure-baby-kj-rare-diseases-personalized-gene-editing-drugs/?_hsmi=38470699