I am excited to share the first preprint from my postdoc work! We found that ligand-receptor pairs are not static and show an antagonistic spatial localization! We show ligand is important to fine tune the amplitude of Wnt oscillations ensuring robust tissue patterning! Check out the preprint!

Ina Sonnen@sonnenlab.bsky.social · 11mo ago

Preprint alert! We combined microfluidics, proteomics, and RNA-seq to map spatiotemporal protein expression during mouse somitogenesis and found a novel regulatory strategy: dynamic antagonistic gradients fine-tune signalling strength. doi.org/10.1101/2025...

Thank you! A special thanks to the organizers for putting this fantastic meeting together @moritzbauer.bsky.social @bracciolilab.bsky.social Hendrik Marks, Susana Chuva de Sousa, Lopes and Niels Geijsen. And to Wilke Meijer and Suzan Stello for working together on this exciting project!!

Ina Sonnen@sonnenlab.bsky.social · last yr.

Well done @virginiar-andra.bsky.social from our lab for being awarded the Best Poster Prize at the International Dutch Embryo Model Meeting today for our work on “Spatiotemporally resolved omics reveals dynamic antagonistic gradients” in embryo segmentation. Congratulations!

Dynamic duo at the cell's edge: Caveolae and the actin cytoskeleton work together to sense and respond to mechanical stress. Caveolae buffer tension, while actin provides structure and force. Ultimate biomechanics team. #CellBiology #Mechanotransduction

The inaugural Hubrecht Symposium is on March 13th, 2025! Join an inspiring day on molecular & developmental biology. This annual event highlights the role of fundamental research in Dutch science. Free of charge! Submit abstracts by February 13th. See www.hubrecht.eu/hubrecht-sym...

I am really happy to announce the first Hubrecht Symposium on March 13th 2025! We will organize these yearly events on a specific topic in molecular and developmental biology to emphasize the importance of fundamental research for Dutch science. Free of charge! www.hubrecht.eu/hubrecht-sym...