Zhulab_PITT
@bokaizhulab.bsky.social
Our lab is broadly interested in studying the functions of proteostasis dynamics, oscillations, and nuclear condensates in aging and diseases.
Please check out our most recent review!!
Trends in Neurosciences@cp-trendsneuro.bsky.social · 5mo agoCheck out the April 2026 issue of Trends in Neurosciences! www.cell.com/issue/S0166-... Featured articles & more: cell.com/trends/neuro... Cover article: ‘Decoding the functions of nuclear speckles in neurodegeneration’, by Xu Chen & Bokai Zhu www.cell.com/trends/neuro...
Check out the April 2026 issue of Trends in Neurosciences! www.cell.com/issue/S0166-... Featured articles & more: cell.com/trends/neuro... Cover article: ‘Decoding the functions of nuclear speckles in neurodegeneration’, by Xu Chen & Bokai Zhu www.cell.com/trends/neuro...
CureAlz is pleased to support researcher Dr. Xu Chen who believes (and is testing) that one way to prevent—or even cure—the Alzheimer's is by boosting the abilities of nuclear speckles, which act as key players in removing damaged proteins. https://ow.ly/kQYt50YH1ee #AlzheimersResearch
analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/...
Unveiling the 12‐Hour Ultradian Rhythm: Biological Foundations, Mechanistic Insights, and Potential Applications
This review synthesizes cross-species ubiquity, molecular mechanisms, and physiological/pathological roles of the 12-h ultradian rhythm, uncovering its core value independent of the circadian clock. ...
analyticalsciencejournals.onlinelibrary.wiley.com
Our new Trends in Neurosciences review explores how nuclear speckles—dynamic nuclear condensates once thought to be passive splicing hubs—coordinate RNA metabolism, stress responses,and proteostasis, and how their dysfunction contributes to neurodegeneration. authors.elsevier.com/a/1mjZRbotqB...
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authors.elsevier.com
link.springer.com/article/10.1.... Hepatic metabolic functions follow a 12-hour cycle rather than a 24-hour cycle, significantly contributing to the liver’s ability to meet nutrient demands throughout the day!!
Client Challenge
link.springer.com
www.biorxiv.org/content/10.1...
SWING domains prime chromatin for nuclear body–mediated gene regulation
Nuclear speckles have long been recognized as RNA-rich nuclear bodies, yet their role in genome organization and gene regulation remains incompletely understood. Using a rapid dTAG-mediated degradatio...
biorxiv.org
www.eurekalert.org/news-release...
Nuclear speckle rejuvenation “next frontier” for treating neurodegeneration
Targeting cellular structures called nuclear speckles could be a completely new approach for treating Alzheimer’s, Parkinson’s and prion diseases, according to new research led by the Univ...
eurekalert.org
It was a great please to share our most recent work on ‘rejuvenating’ nuclear speckles to alleviate proteinopathies. www.nature.com/articles/s41...
SON-dependent nuclear speckle rehabilitation alleviates proteinopathies - Nature Communications
Here the authors show that rehabilitating nuclear speckles, membraneless organelles involved in mRNA processing and gene regulation, can boost protein quality control and reduce toxic protein buildup,...
nature.com
www.pittmed.pitt.edu/news/12-hour.... It is a nice news piece on our earlier work demonstrating the existence of 12h rhythms in ‘free-living’ humans.
Left by the tides
Traces of ocean-dwelling ancestors seem to live on in our biological rhythms.
pittmed.pitt.edu
It is a great review!!
Prof. Fred Gachon (he/him)@fgachon.bsky.social · last yr.It was very interesting to write this review article about 12hr rhythms in marine species and mammals. Almots 20 years after the first description of these 12hr rhythms in mouse liver, we still don't know a lot about their role and their regulation! rdcu.be/epdti