📣NAR is recruiting a new Executive Editor!📣Seeking an established researcher with expertise in RNA biology and translation mechanisms to help shape the journal's scientific direction, oversee peer review, and support its growth. Apply by 30 Sept 2026: academic.oup.com/nar/pages/ex...

Congratulations to the authors on their #NARCANCER publication! 🎉 Deleterious #SMC5/6 variants may predict higher #tumormutationalburden and better responses to #immunotherapy, highlighting their potential as #biomarkers for #precisioncancertherapy.

Bill Dynan - NAR Cancer Editor@nar-cancer-editor.bsky.social · 2mo ago

Can SMC5/6 status help guide precision cancer therapy? A new NAR Cancer study links deleterious SMC5/6 variants to tumor mutational burden and immunotherapy responses, driven via POLE dysfunction and mismatch repair deficiency.https://academic.oup.com/narcancer/article/8/2/zcag012/8688771

New research in #NARMolecularMedicine shows that #musclestemcells retain intrinsic #inflammatory changes, with aberrant #TNFα signaling and reduced #H3.3 impairing muscle regeneration, pointing to #newtherapeutic opportunities in #dermatomyositis beyond #interferon. 🧬 doi.org/10.1093/narm...

📣The 24th annual NAR Web Server Issue is now online! 📣Explore 47 new web servers spanning a range of scientific and medical applications. Congratulations and thanks to all authors, editors and reviewers for your contributions!🧬 #NARWebServer #MolecularBiology #OpenAccessIssue

📣 Applications are open for the next NAR Early Career Investigator (ECI) Advisory Board cohort! Work with Executive Editors, help shape journal strategy, and gain insight into peer review during a 2-year term. Apply by 1 Nov 2026: lnkd.in/g233ZCAf #ECR #NAR #AcademicPublishing #MolecularBiology

⭐ #NARBreakthrough ⭐ 🩸🔬 Unexpected role for #ZEB1 in #redbloodcell development! ZEB1 cooperates with KLF1 to regulate #erythroidmaturation and #enucleation, revealing a new regulatory axis essential for #erythropoiesis. 🧬✨ Read the article here: doi.org/10.1093/nar/... @igmm-montpel.bsky.social

⭐ #NARBreakthrough ⭐ 🔬 How do #cyanobacteria avoid overreacting to stress? New research shows that antisense RNAs keep the #stress-response gene nblA off under normal conditions, preventing damage while enabling rapid adaptation when nutrients become limiting. 📖 Read here doi.org/10.1093/nar/...

⭐ #NARBreakthrough ⭐ 🔬New research reveals that #Trypanosomabrucei CRK9 and human CDK11 share a role in #RNAsplicing through #SF3B1 phosphorylation. An unexpected link with implications for #antiparasitic drug development. 📖 Read the article here: doi.org/10.1093/nar/... @uconnhealth.bsky.social

Big congratulations to the authors! 🎉🦠 Using RNA-seq, this study uncovers overlooked viral RNA species and supports a premature termination model for astrovirus subgenomic RNA synthesis, resolving a long-standing replication mystery. 🔬✨ #NARMolecularMedicine #Virology @universitypress.cambridge.org

Valeria Lulla@valerialulla.bsky.social · 4mo ago

🚨 New paper from the lab! 🚀 We explore “The dynamics and strategy of RNA replication in astroviruses”, now out in NAR Molecular Medicine. Many thanks to all co-authors and congratulations to David Noyvert on his first first-author paper🎉 doi.org/10.1093/narm...

Few cancer driver mutations have been identified in promoters, maybe for technical reasons. New assay targets >3,000 promoters — hits in CDK4, SMAD3, and GATA3 in breast cancer provide promising leads for functional follow-up. academic.oup.com/narcancer/ar... #CancerGenomics #NonCoding #Promoters

Sensitive detection of somatic mutations in GC-rich cancer gene promoters

Abstract. Somatic mutations in protein-coding genes and noncoding regulatory regions are the major drivers of cancer. Only a relatively small number of som

academic.oup.com

📣 Applications are open for the next Editor‑in‑Chief of NAR Cancer! 📣 Lead an open‑access journal at the forefront of nucleic acids and cancer research. We welcome applications until 1st Aug 2026. More details: academic.oup.com/narcancer/pa... #NARCancer #EditorInChief #CancerResearch

⭐ #NARBreakthrough! ⭐ New #cryo-EM study reveals how #transcription factor IWS1 promotes #RNApolII #elongation. Its C-terminus contains #modularmotifs that bind elongation components, stabilizing the complex. IWS1 also competes with #RECQL5 for Pol II binding. 📖 Read here: doi.org/10.1093/nar/...

⭐ #NARBreakthrough! ⭐ 🔬 New study by @magistratolab.bsky.social and @pokorna.bsky.social reveals how TAT-SF1 acts as a “molecular latch,” storing strain in #U2snRNP to drive branch-helix formation. A “loaded-spring” model for #splicingfidelity. 📖 Read the article: doi.org/10.1093/nar/...

How do memories last a lifetime when proteins turn over in months? A new NAR review by Peter Cook suggests long‑term memory may stem from transcriptional gene clusters and even pyrophosphate shaping calcium signals. 📖 doi.org/10.1093/nar/... #LongTermMemory #Transcription #ReviewArticle

🧬 A new review article highlights 50 years of discoveries describing DNA’s many alternative forms which have trailblazed nucleic acid research. Read the full article at academic.oup.com/nar/article/... #DNAResearch #GenomeBiology #NucleicAcidsResearch #MolecularBiology #HistoryofDNA

⭐ #NARBreakthrough ⭐ New study delivers the first chromosome-level phased assemblies, uncovering >50,000 #structuralvariants and rescuing millions of #unmappable reads in BJ and IMR-90 human cell lines. 📖 Read here: doi.org/10.1093/nar/... #Genomics #CellLines #CommunityResource

⭐ #NARBreakthrough! ⭐ 🔬New study shows how the #RAD52 homolog Mgm101 anneals complementary ssDNA during single-strand annealing repair, forming an unwound #duplex intermediate. #Structural insights reveal a new #therapeutic potential in #BRCA-mutant cancers. 📖 Read here: doi.org/10.1093/nar/...

📣 New NARMME collection: Targeting & Harnessing Nucleic Acids for Therapeutic Discovery. Submit work on nucleic acid chemistry, delivery, mechanisms, safety, targeting & therapeutic applications. Info: lnkd.in/eipeJmaw Submit: lnkd.in/ej9GNs3B #DrugDiscovery #TherapeuticInnovation

🔬 Modern #bioinformatics workflows are complex and hard to reproduce. #systemPipeR helps researchers design, run, and track analysis #pipelines in one framework, integrating R + bioinformatics tools, HPC support, and automated #reports for #transparency. Read more doi.org/10.1093/narg... #NARGAB

How does c-MYC overexpression drive transcriptional rewiring in cancer? Sundaram et al report a plausible mechanism involving co-option of TRE/AP1 sites, mainly at enhancers, rising with MYC levels and linked to repression. academic.oup.com/narcancer/ar...

MYC and AP-1 oncogenes cooperatively bind enhancers to rewire transcription

Abstract. The transcription factor c-MYC (MYC) is deregulated in ~70% of human cancers. Through de novo motif discovery analysis on published MYC ChIP-seq

academic.oup.com

HSF1 drives cancer stress resilience but is hard to target—clever screen identifies spliceosome helicase DHX8 as a druggable regulator of HSF1 splicing→HSF1 program gone, cancer loses stress defenses. Editor's Choice in NAR Cancer. #PrecisionOncology #Spliceosome academic.oup.com/narcancer/ar...

Human DEAH-box helicase 8 regulates HSF1-mediated stress response and cancer-associated pre-mRNA splicing in tumour cells

Abstract. Transcription factor heat shock factor 1 (HSF1) orchestrates the cellular stress response, promoting malignant transformation, unchecked prolifer

academic.oup.com

✨A new review in #NARMolecularMedicine explores how #mitochondrialDNA inheritance, copy number changes, and coordination with the nuclear genome shape development, and how #AssistedReproductiveTechnologies may disrupt this balance. Read the review here: doi.org/10.1093/narm... #EditorsChoice

⭐ #NARBreakthrough ⭐ 🧬An endosomal #mRNAtransporter uses teamwork between its 3 RNA recognition motifs (RRMs) to distinguish #accessory from #essential binding sites. Select #cargomRNAs get “VIT” (very important transcript) status for premium transport. 🚚 Read more here: doi.org/10.1093/nar/...

Huge congratulations to Tomáš Brůna @tomasbruna.bsky.social and John T. Lovell @jotlovell.bsky.social on their new paper in NAR Genomics and Bioinformatics!! 🎉🚀 Absolutely fantastic work—excited to see this contribution making waves in the field! 👏🔥

John Lovell@jotlovell.bsky.social · 6mo ago

This article is now published! academic.oup.com/nargab/artic... We’ve added a few new analyses. First off, we show that, while gene presence absence variation (PAV) scales with evolutionary distance in both plants and animals, the base level and rate of accrual are both twice as high in plants.

📣 New NARMME collection: Targeting & Harnessing Nucleic Acids for Therapeutic Discovery. Submit work on nucleic acid chemistry, delivery, mechanisms, safety, targeting & therapeutic applications. Info: lnkd.in/eipeJmaw Submit: lnkd.in/ej9GNs3B #DrugDiscovery #TherapeuticInnovation

📣 NAR Cancer Call for Papers: Seeds of Cancer, Decades of Silence. Submit work on early cancer initiation, ageing, environment, clonal evolution, genome maintenance and more before July 2026. 👉 academic.oup.com/narcancer/pa... #NARCancer #CancerResearch #Genomics #Epigenetics

⭐NAR Breakthrough! ⭐ Back-to-back NAR studies show #Palbociclib binds #HIV TAR RNA with low affinity & striking specificity. Induced-fit RNA refolding creates a #druggable pocket, blocking #SEC recruitment.📖 Read the articles here: doi.org/10.1093/nar/... doi.org/10.1093/nar/... #DrugDiscovery

⭐ #NARBreakthrough! ⭐ 🧬 New study uncovers how #RNAstructures control stochastic exon selection in Dscam1 genes. #Balancer RNA structures and a #multi-subunit RNA architecture coordinate spatial and temporal splicing 🔬✨ Read the full article here: doi.org/10.1093/nar/... #AlternativeSplicing

⭐NAR Breakthrough! ⭐ 🧬 New #cryo-EM work shows the #humanINO80 motor adapts to DNA unwrapping and can remodel altered particles like #hexasomes - highlighting its versatility across #nucleosome states. 🔬✨ @lmu.de @genecenter-lmu.bsky.social Read the full article here: doi.org/10.1093/nar/...

#SpinalMuscularAtrophy (SMA) is treated with the ASO Nusinersen (Spinraza™) to restore SMN via SMN2 splicing. 🧬 New work reveals diverse off-target effects linked to its chemistry—and shows how to mitigate them. 🚀 #NARMolecularMedicine #RNATherapeutics #ASO 🔗 Read here: doi.org/10.1093/narm...