New paper out from the lab, showing how ATR activity controls RNAPII transcription when genes are replicated www.cell.com/iscience/ful... 🥳🥳🥳

ATR activity regulates DNA replication and RNA polymerase II transcription during S-phase

Molecular biology; Epigenetics; Cell biology

cell.com

Still time to apply for this post!!!

Marco Saponaro@m-saponaro.bsky.social · 10mo ago

3-year technician position with a possibility of doing a PhD available to study chromatin replication and ubiquitylation using cell free system of Xenopus laevis egg extract. Closing date 28/10/25. Get in touch @agagambus.bsky.social or @m-saponaro.bsky.social for informal inquiries lnkd.in/etU3yydb

3-year technician position with a possibility of doing a PhD available to study chromatin replication and ubiquitylation using cell free system of Xenopus laevis egg extract. Closing date 28/10/25. Get in touch @agagambus.bsky.social or @m-saponaro.bsky.social for informal inquiries lnkd.in/etU3yydb

Honoured to be in Birmingham to mark Bryan Turner’s retirement- a gentleman and giant of epigenetics.

So happy to see this finally out, another collaboration with @agagambus.bsky.social!

Aga Gambus@agagambus.bsky.social · last yr.

It is finally out 👍😀. Great job of the team (mostly absent from Bsky) and @m-saponaro.bsky.social CDK-driven phosphorylation of TRAIP is essential for mitotic replisome disassembly and MiDAS url: academic.oup.com/nar/article/...

Deadline for submitting abstracts is fast approaching, but there is still time to register for this conference and to present your science!!!

Ferenc Mueller@ferencmueller.bsky.social · last yr.

The Birmingham Centre for Genome Biology invites you to join us at our 10th year anniversary conference! Website and Registration here: shorturl.at/rvJSr Fantastic speakers, and a very cost-efficient meeting for ECRs and all. Talk slots are available. See you in Brum on 11-12th September 2025!

The new University of Birmingham Doctoral school has just launched! Very exciting times for Postgraduate research at the university of Birmingham! www.birmingham.ac.uk/study/postgr...

The University Doctoral School - University of Birmingham

Advance your research career with the University of Birmingham's Doctoral School. Access expert support, funding, and development opportunities

birmingham.ac.uk

Birmingham Centre for Genome Biology 2025 Anniversary Conference, 11-12 September! This symposium covers DDR and gene regulation. Register here: uobevents.eventsair.com/birmingham-c...

The Birmingham Centre for Genome Biology invites you to join us at our 10th year anniversary conference! Website and Registration here: shorturl.at/rvJSr Fantastic speakers, and a very cost-efficient meeting for ECRs and all. Talk slots are available. See you in Brum on 11-12th September 2025!

Next Tuesday's webinar will feature @agagambus.bsky.social and @chowdhurylab.bsky.social. Join us on June 3rd at 5PM Rome / 11AM NYC for a lively discussion on DNA replication and repair! Zoom link: uniroma1.zoom.us/j/95149984403 Become part of our community: docs.google.com/forms/d/e/1F...

@unibirmingham.bsky.social

Paloma Garcia @pggarcialab.bsky.social · last yr.

Our last work on triple negative breast cancer stem cells now in BiorXiv!! Let's hope for a smooth reviewing process!! @m-saponaro.bsky.social @breastcancernow.bsky.social @davieslab-ch3.bsky.social @robclarkelab.bsky.social 😃 www.biorxiv.org/content/10.1...

Come and join us to celebrate the 10th anniversary of the BCGB, with a great selection of international speakers! Very convenient conference, open to anyone interested in the field of genome biology!

Our last work on triple negative breast cancer stem cells now in BiorXiv!! Let's hope for a smooth reviewing process!! @m-saponaro.bsky.social @breastcancernow.bsky.social @davieslab-ch3.bsky.social @robclarkelab.bsky.social 😃 www.biorxiv.org/content/10.1...

MYBL2 maintains stemness and promotes theta-mediated end joining in triple negative breast cancer

Triple negative breast cancer (TNBC) has a poor prognosis due to limited treatment options and high metastasis risk. Breast cancer (BC) stem/progenitor cells, also known as tumour initiating cells, ar...

biorxiv.org

My lab is #hiring! I am recruiting for two #Postdoc positions investigating the Alternative Lengthening of Telomeres mechanism. www.jobs.ac.uk/job/DLO693/r... www.jobs.ac.uk/job/DLP016/r... #Telomere #DNAreplication #DNArepair #cancer #glioma #UKRI #MRC #universityofbirmingham #NGS

Research Fellow at University of Birmingham

Discover an exciting academic career path as a Research Fellow at jobs.ac.uk. Don't miss out on this job opportunity - apply today!

jobs.ac.uk

Christmas fun with @m-saponaro.bsky.social lab. It was great to see some past and future members of the lab. Christmas cheer all around 😀

RNA Polymerase II subunits overexpressions induce genome instability and deregulate transcription https://www.biorxiv.org/content/10.1101/2024.11.20.622938v1

RNA Polymerase II subunits overexpressions induce genome instability and deregulate transcription https://www.biorxiv.org/content/10.1101/2024.11.20.622938v1

Independently of the pathways or circuits deregulated in cancer cells, these present altered transcr

biorxiv.org

Pls share 🌟Join the IMP as a Group Leader We are 👀 for a colleague, ready to lead a groundbreaking research program. Enjoy generous funding, outstanding facilities & a vibrant scientific community in one of the world's most livable cities @impvienna.bsky.social 👉https://tinyurl.com/impgl2025

What happens when you overexpress one subunit of the RNA Pol II? Well, it depends on the subunit, but all deregulate transcription and induce genome instability @agagambus.bsky.social www.biorxiv.org/content/10.1...

RNA Polymerase II subunits overexpressions induce genome instability and deregulate transcription

Independently of the pathways or circuits deregulated in cancer cells, these present altered transcription patterns, often also direct consequence of deregulation of transcription factors. In this sen...

biorxiv.org