RANKOR: A Machine Learning Model for Drug Repurposing on Individual-Level Single Cell Data

<p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="first" dir="auto" id="d26947238e95">Precision oncology aspires to align cancer patients with therapies that most effectively ...

drugrepocentral.scienceopen.com

<i>MAPK8IP3</i>-Related Neurodevelopmental Disorder: Case Report and Therapeutic Rationale for a Truncating Variant

<p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="first" dir="auto" id="d4280225e217">This report explores a therapeutic hypothesis for addressing the potential effects of a ...

drugrepocentral.scienceopen.com

A New UI for AI-Driven Drug Repurposing in Rare Genetic Diseases: Real-World Impact from the NCATS Translator Program

<p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="first" dir="auto" id="d90562e89">The NIH NCATS Translator program now exposes <b>&gt; 200 million semantically...

drugrepocentral.scienceopen.com

Inference of Gene Regulatory Networks for Drug Repurposing: A CLR-Based Strategy to Predict Transcriptional Drug Effects

<p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="first" dir="auto" id="d9292592e148">Drug repurposing provides a cost-effective approach to identifying new therapeutic indic...

drugrepocentral.scienceopen.com

RePo-SUDOE: A Transnational Network for Drug Repurposing in the SUDOE Space

<p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="first" dir="auto" id="d13493990e380">The development of new drugs is hindered by high failure rates, substantial costs, and ...

drugrepocentral.scienceopen.com

RePo-SUDOE Conference Series

<p>This conference will provide a platform to discuss the latest trends, European initiatives and success stories in the use of existing drugs. In addition, round table discussions will address the ch...

drugrepocentral.scienceopen.com

From Literature to Knowledge Graphs to Drug Repurposing

<p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="first" dir="auto" id="d392105e255">Network-based drug repurposing requires the seamless synthesis of knowledge from both the...

drugrepocentral.scienceopen.com

Drugst.One DREAM - Drug Repurposing through Expert Annotation and Modification

<p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="first" dir="auto" id="d814479e258">Complex diseases often lack an actionable understanding of their underlying causal biolog...

drugrepocentral.scienceopen.com

From Hype to Health Check: Critical Evaluation of Drug Response Prediction Models with DrEval

<p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="first" dir="auto" id="d1367117e186">Large-scale drug sensitivity screens have enabled training drug response prediction mode...

drugrepocentral.scienceopen.com

Comprehensive Network Medicine-Based Drug Repositioning via Integration of Therapeutic Efficacy and Side Effects

<p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="first" dir="auto" id="d26893407e114">Despite advances in modern medicine that led to improvements in cardiovascular outcomes, ...

drugrepocentral.scienceopen.com

How can patient-based evidence support health technology assessment in mechanism-based drug repurposing?

<p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="first" dir="auto" id="d2881e105"> <b>Background:</b> Health Technology Assessment (HTA) is a multi...

drugrepocentral.scienceopen.com

VRG‑145: A Synergistic Drug Repurposing Strategy for Enhanced Migraine Prophylaxis

<p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="first" dir="auto" id="d1880278e181">Migraine prophylaxis remains an area of substantial unmet medical need. Current therapies ...

drugrepocentral.scienceopen.com

The Business Case for Drug Repurposing in Cri du Chat Syndrome Patients

<p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="first" dir="auto" id="d13555163e151">Cri du Chat syndrome (CdCS) is a rare genetic disorder caused by spontaneous deletion o...

drugrepocentral.scienceopen.com

An Integrative Systems Medicine Framework for Ischemic Stroke: In Silico-Based Target Identification, Network Pharmacology, and Immune Mechanistic Redefinition

<p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="first" dir="auto" id="d276929e183">Despite decades of translational research, translational stroke research has yield to no ...

drugrepocentral.scienceopen.com

drugrepocentral.scienceopen.com

Patient-derived lymphoma organoids and repurposed drugs: novel solutions for improved B cell lymphoma treatment

<p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="first" dir="auto" id="d816596e219">B cell lymphomas (BCL) are a heterogenous group of hematologic malignancies, with over 70 identified subtypes. Current first line treatment for all subtypes is rituximab and chemotherapy regimen (R-CHOP); of the treated patients, up to 40-60% relapse or have refractory disease, with typically higher mortality rates. Therefore, more efficient treatment, but also improved <i>ex vivo</i> research models are needed to study the treatment response and resistance. To overcome the expensive and time-consuming process of drug discovery and development, we aim to combat the lymphoma heterogeneity with repurposed drugs, especially focusing on cationic amphiphilic drugs (CADs) that damage cancer cell lysosomes. </p><p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" dir="auto" id="d816596e224">Lysosomes are central organelles in nutrient sensing and cellular metabolism. Malignant transformation rewires cellular metabolism to boost growth. In turn, cancer cells increase lysosomal production and activity to meet the metabolic needs. Our current results indicate that targeting the reported cancer cell lysosomal ‘weakness’ with repurposed CADs Ebastine and Penfluridol prevents pro-survival cell signaling, and suppresses long-term tumor outgrowth in B lymphoma cell lines, patient blood B cells, and in patient lymph node-derived organoids. </p><p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" dir="auto" id="d816596e226">We have developed a novel patient-derived lymphoma organoid model as an <i>ex vivo</i> drug assay platform from patients’ own cancer tissue. With combining the lymphoma organoid model and repurposed drugs, this study provides a simpler and cost-effective, yet translationally relevant clinical solution for personalized medicine and improved treatment of BCL patients. </p>

drugrepocentral.scienceopen.com

Leveraging Cancer Drug Metabolites for Precision Drug Repurposing

<p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="first" dir="auto" id="d26971189e181">Precision oncology benefits only a subset of patients, with approved drugs targeting le...

drugrepocentral.scienceopen.com

Repurposing Drugs through Network Pharmacology in Advanced Thyroid Cancer: From Bench to Bedside

<p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="first" dir="auto" id="d446414e216">Advanced thyroid cancer patients have limited treatment options and rarely result in a cu...

drugrepocentral.scienceopen.com

Role of Chemoinformatics and Machine Learning in Drug Repurposing

<p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="first" dir="auto" id="d13111663e103">Drug discovery is both a long and expensive process, characterized by low success rates and high…

drugrepocentral.scienceopen.com

Technology, Mind, and Behavior

An open access, interdisciplinary journal from the American Psychological Association (APA) featuring research on human–technology interaction. Explore articles on the impact of artificial intelligence, social media, gaming, nanotechnology, and much more.

scienceopen.com

The IET

<h4>Working to engineer a better world</h4><p>We are the IET and we inspire, inform and influence the global engineering community to engineer a better world. As a diverse home across engineering and…

scienceopen.com