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Ian Duguid

@ianduguid.bsky.social

Group leader @ University of Edinburgh, neuroscientist interested in how the brain plans, executes and adapts complex motor actions.

7 Posts661 Follower162 Folgt
FarrowLab@farrowlab.bsky.social · last yr.

Fantastic to see this collaborative work with Hopi Hoekstra out in Nature (tinyurl.com/3at3zvby). Lead by @felixbaier.bsky.social and @katjareinhard.bsky.social. Not possible without @bramnuttin.bsky.social , Chen Liu and @arnausd.bsky.social. Excited to see where this work leads.

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NERF@nerflabs.bsky.social · last yr.

📢 New paper out in Nature! The Hoekstra lab at Harvard and @farrowlab.bsky.social lab at NERF reveal how a brain switch is tuned by evolution to control freezing vs fleeing in two sister species of deer mice. 👏 Huge congratulations to the entire team https://tinyurl.com/3at3zvby

Petr Znamenskiy@petrznam.bsky.social · last yr.

1/ Mapping synaptic connectivity between individual neurons is extremely laborious. We developed BRISC, a new method that makes it possible to map inputs onto 100s of neurons in the same animal in a matter of weeks! Led by Alex Becalick and @antblot.bsky.social. 🧵 www.biorxiv.org/content/10.1...

Barcoded Rabies In Situ Connectomics for high-throughput reconstruction of neural circuits

Sequencing of oligonucleotide barcodes holds promise as a high-throughput approach for reconstructing synaptic connectivity at scale. Rabies viruses can act as a vehicle for barcode transmission, than...

biorxiv.org

Niccolò Zampieri@niccolozampieri.bsky.social · last yr.

🚨PhD position opening on a project aimed at defining the role of different sources of sensory information on locomotor control. 📢 ⬇️ www.mdc-berlin.de/zampieri#t-j...

Zampieri Lab

The execution of coordinated movements depends on the ability to dynamically adapt motor plans to external conditions and perturbations. Spinal circuits integrate motor commands and sensory information in order to generate precise patterns of muscle activation. The detection of different sensory stimuli and their integration with descending commands from the brain and local spinal networks is therefore critical for motor control. Our laboratory studies the mechanisms controlling assembly and function of spinal sensorimotor circuits by combining transcriptomics, genetics, tracing, and behavioral analyses to reveal how these circuits are first organized during development and then function in controlling movement and coding of sensory information.

mdc-berlin.de

The Transmitter @thetransmitter.bsky.social · last yr.

A statistical error known as pseudoreplication appears in more than half of recent mouse studies on neurological disorders, according to a new study. Peter Kind and Constantino Elfetheriou tell Lauren Schenkman why researchers should pay attention. www.thetransmitter.org/pseudoreplic...

Sounding the alarm on pseudoreplication: Q&A with Constantinos Eleftheriou and Peter Kind

Most studies of neurological disorders in mice erroneously treat multiple samples from a single animal as independent replicates, according to a new analysis. But scientists and journals can take…

thetransmitter.org

Takaki Komiyama @takakikomiyama.bsky.social · last yr.

Our paper is out in Nature. By examining various inputs to the motor cortex during learning, we found that thalamic inputs learn to activate the cortical neurons encoding the movement being learned. Tour de force by Assaf in collab with Felix and Marcus. Congrats! www.nature.com/articles/s41...

Motor learning refines thalamic influence on motor cortex - Nature

Imaging and optogenetics in mice provide insight into the interplay between the primary motor cortex and the motor thalamus during learning, showing that thalamic inputs have a key role in the executi...

nature.com

Andrew MacAskill@macaskillaf.bsky.social · 2y ago

Huge congrats to @karyna-mi.bsky.social for her paper published today in Science! She found that the hippocampus is really important for a key strategy we use to make decisions called hidden state inference! 🧪 🧠https://www.science.org/doi/10.1126/science.adq5874 1/7

Hidden state inference requires abstract contextual representations in the ventral hippocampus

The ability to use subjective, latent contextual representations to influence decision-making is crucial for everyday life. The hippocampus is hypothesized to bind together otherwise abstract combinat...

science.org

Jaan Aru@jaanaru.bsky.social · 2y ago

The craziest paper I have ever done is this thought experiment with Albert Gidon and Matt Larkum. In the first journal, reviewer 1 recommended that we should not try to publish this; reviewer 2 called it "wacky". Thanks for the motivation: A sequel is coming up! journals.plos.org/plosbiology/...

Does brain activity cause consciousness? A thought experiment

The authors of this Essay examine whether action potentials cause consciousness in a three-step thought experiment that assumes technology is advanced enough to fully manipulate our brains.

journals.plos.org