Tessera

Metal-dependent regulated cell death: Molecular architecture and translational frontiers 💡 This review explores emerging metal-dependent cell death pathways and their therapeutic potential in cancer, tissue degeneration, and immunotherapy. onlinelibrary.wiley.com/doi/10.1002/...

Metal‐dependent regulated cell death: Molecular architecture and translational frontiers

Intracellular metal dyshomeostasis orchestrates distinct regulated cell death programs, including iron-driven ferroptosis, copper-mediated cuproptosis, calcicoptosis, newly designated zincoptosis, mn...

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Spatial omics in the AI era: Technologies, algorithmic ecosystems, biological applications, and large model perspectives 🤖 💡 Compares spatial omics platforms and algorithms, highlights key challenges, and explores AI-driven advances in spatial biology. onlinelibrary.wiley.com/doi/10.1002/...

Spatial omics in the AI era: Technologies, algorithmic ecosystems, biological applications, and large model perspectives

This review focuses on spatial omics, covering the introduction and comparison of technology platforms, explanation and recommendation of algorithm ecology, demonstration of biological applications, ....

onlinelibrary.wiley.com

Wekemo Bioincloud 2026: An AI‐enabled platform for standardized multi‐omics data analyses onlinelibrary.wiley.com/doi/10.1002/...

Wekemo Bioincloud 2026: An AI‐enabled platform for standardized multi‐omics data analyses

An AI-powered multi-omics cloud platform integrating 41 standardized workflows, 126 visualization tools, and full-lifecycle research intelligence to enable accessible, reproducible, and end-to-end in...

onlinelibrary.wiley.com

Soil-derived, gut-dominant generalist bacteria shape the fitness of folivorous larvae 🐛 💡 Soil-derived Ralstonia insidiosa and Delftia sp. widely colonize folivorous larvae, with opposing effects on larval growth. onlinelibrary.wiley.com/doi/10.1002/...

Soil‐derived, gut‐dominant generalist bacteria shape the fitness of folivorous larvae

Whether Lepidoptera harbor a conserved core gut microbiome has long remained contentious. Through large-scale microbiome profiling of folivorous larvae, their host plants, and associated soils across....

onlinelibrary.wiley.com

Microbiome and aging: Trajectories of microbiome age across human ecosystems and their systemic effects onlinelibrary.wiley.com/doi/10.1002/...

Microbiome and aging: Trajectories of microbiome age across human ecosystems and their systemic effects

Microbiome age (MA) has emerged as an innovative biomarker of biological aging, reflecting host aging trajectories through dynamic alterations in microbial composition, function, and host–microbe int...

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👁️Spatial multi-omics unveils sphingolipid metabolic reprogramming within the retinal pathological niche 💡 Trem2⁺ microglia and the TREM2–SPTLC2 axis are linked to sphingolipid remodeling and retinal ganglion cell degeneration. onlinelibrary.wiley.com/doi/10.1002/...

Spatial multi‐omics unveils sphingolipid metabolic reprogramming within the retinal pathological niche

Spatial multi-omics of the mouse ocular globe after retinal ischemia-reperfusion (RIR) injury identifies the ganglion cell layer (GCL) as an immunometabolic niche where Trem2+ microglia closely assoc...

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Multi-omics-driven precision medicine (MODPM) is understood as a multiscale decision architecture that links molecular heterogeneity, tissue context, and patient-level trajectories. onlinelibrary.wiley.com/doi/10.1002/...

Multi‐omics–driven precision medicine

Multi-omics-driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome prof...

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🧐The Human Biomarker Navigator integrates biomarkers across nine physiological systems, organs, and diseases into a comprehensive navigation framework. #Biomarkers #SystemsBiology onlinelibrary.wiley.com/doi/10.1002/...

Human biomarker navigator

The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross-organ biomarker networks, biomarker classification, and technology-driven paradigms. It maps how biomarkers l...

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The gut microbiome is more than a community of microbes—it functions as an organ-like system shaping metabolism, immunity, and gut–brain signaling. #Gut #Microbiome onlinelibrary.wiley.com/doi/10.1002/...

The gut microbiome organ

The gut microbiome can be conceptualized as a distributed organ-like functional system with spatially structured organization, broad biochemical capacity, and continuous bidirectional communication w...

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Two near‐complete assemblies reveal R‐subgenome structural and centromeric divergence associated with reproductive isolation in hexaploid triticale onlinelibrary.wiley.com/doi/10.1002/...

Two near‐complete assemblies reveal R‐subgenome structural and centromeric divergence associated with reproductive isolation in hexaploid triticale

We present two near-complete triticale genome assemblies and perform pan-centromere analyses across >200 haplotypes from parental species, synthetic allopolyploids, cultivars, and 337 resequenced acc...

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⚡️A new piece of the puzzle in recurrent pregnancy loss: Hyperoside alleviates endometrial stromal cell senescence, restores decidualization, and reduces embryo loss partly by mitigating pathological R-loop accumulation. onlinelibrary.wiley.com/doi/10.1002/...

Hyperoside alleviates endometrial stromal cell senescence in unexplained recurrent spontaneous abortion via DHX9‐mediated R‐loop resolution

This study suggests that the food-derived flavonoid hyperoside may act as a natural DExH-box helicase 9 (DHX9) modulator, directly targeting Thr419 of DHX9 to help resolve pathological R-loop accumul...

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🐄Microbial DNA methylation links rumen transcriptional activity to methane emission divergence in dairy cows onlinelibrary.wiley.com/doi/10.1002/...

Microbial DNA methylation links rumen transcriptional activity to methane emission divergence in dairy cows

Genome-resolved methylomics uncovers the first DNA methylation atlas of the dairy cow rumen microbiome. Microbial DNA methylation profiles diverge between low- and high- methane-emitting dairy cows d...

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Environmental chemicals don’t just cause cancer—they can reshape the tumor immune microenvironment and undermine antitumor immunity and immunotherapy. onlinelibrary.wiley.com/doi/10.1002/...

Environmental chemicals and the tumor immune microenvironment

Impact of representative environmental chemicals on tumor immune microenvironment (TIME). Representative environmental chemicals are ubiquitously distributed across air, soil, aquatic systems, and bi...

onlinelibrary.wiley.com

Dietary fiber‐based oral nanovaccine promotes gut‐to‐nose trafficking of regulatory cells and drives antigen‐specific tolerance to relieve airway allergy onlinelibrary.wiley.com/doi/10.1002/...

Dietary fiber‐based oral nanovaccine promotes gut‐to‐nose trafficking of regulatory cells and drives antigen‐specific tolerance to relieve airway allergy

Current therapies for allergic rhinitis primarily provide symptomatic relief but fail to establish durable antigen-specific immune tolerance. Here, we developed an oral nano-dietary fiber (NDF) platf...

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The gut microbiome may signal gestational diabetes risk long before diagnosis: an integrated metagenomic and lipidomic study reveals a Ruminococcus bicirculans–lactosylceramide axis linked to metabolic dysregulation and insulin signaling. onlinelibrary.wiley.com/doi/10.1002/...

A gut microbiome‐lipid axis in early pregnancy is associated with metabolic dysregulation and diabetes risk

Early-pregnancy microbiome and lipidome profiling identified a microbiome-glycosphingolipid axis associated with later gestational diabetes mellitus (GDM) risk. In the prospective pregnancy cohort, w...

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Limosilactobacillus reuteri enhances ovarian function and female fertility ! Limosilactobacillus reuteri Y15 (LRY15)-derived polyunsaturated fatty acids (PUFAs) restore follicular cell-cell junctions and fertility. onlinelibrary.wiley.com/doi/10.1002/...

<i>Limosilactobacillus reuteri</i> enhances ovarian function and female fertility

Limosilactobacillus reuteri Y15 (LRY15)-derived polyunsaturated fatty acids (PUFAs) restore follicular cell-cell junctions and fertility. LRY15, isolated from the intestine of alginate oligosaccharid...

onlinelibrary.wiley.com

Single‐cell profiling of peripheral blood reveals acute‐phase immune dysregulation in human scrub typhus onlinelibrary.wiley.com/doi/10.1002/...

Single‐cell profiling of peripheral blood reveals acute‐phase immune dysregulation in human scrub typhus

Integrated single-cell RNA sequencing, spectral flow cytometry, immune-receptor repertoire profiling, and plasma proteomics revealed coordinated peripheral immune remodeling during acute scrub typhus...

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👶Maternal and infant gut microbiome Early-life gut microbiome assembly is a pivotal determinant of lifelong health. onlinelibrary.wiley.com/doi/10.1002/...

Maternal and infant gut microbiome

The maternal–infant continuum involves critical windows of host–microbiota co-adaptation. Preconception, maternal and paternal microbiomes modulate immunity and reproduction. During pregnancy, a gut–...

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🌱The plant microbiome: From ecological foundations to precision microbial engineering for sustainable agriculture onlinelibrary.wiley.com/doi/10.1002/...

The plant microbiome: From ecological foundations to precision microbial engineering for sustainable agriculture

From ecological principles to precision engineering of plant microbiomes for sustainable agriculture. The plant holobiont integrates diverse microbial niches (including rhizosphere, endosphere, phyll...

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Beyond omics, beyond description. This Correspondence calls for a shift from profiling fermentation microbiomes to causally designing them for robust and scalable biomanufacturing. onlinelibrary.wiley.com/doi/10.1002/...

Beyond omics: From descriptive profiling to causal and scalable design of fermentation microbiomes

Fermentation microbiomes play essential roles in food production, feed preservation, waste valorization, and diverse sustainable industrial processes. Although multi-omics and systems biology have su...

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🔥A promising strategy for age-related infertility! Bazi Bushen Capsule improves endometrial function by restoring mitochondrial homeostasis, offering new hope for women of advanced maternal age. onlinelibrary.wiley.com/doi/10.1002/...

Bazi Bushen Capsule restores fertility by targeting mitochondrial health in aging endometrium

Bazi Bushen Capsule (BZBS) mitigates age-related endometrial dysfunction by activating AMPK − SIRT3 signaling. Luteolin, a key bioactive component, restores mitochondrial homeostasis via PINK1/Parkin...

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We've moved beyond asking whether micro- and nano-plastics are in our bodies. Now it's time to ask what they do. 👏This Correspondence proposes internal burden as the bridge from exposure to health risk. onlinelibrary.wiley.com/doi/10.1002/...

Exposure to micro‐ and nano‐plastics: From human internal burden to systems‐level health‐risk interpretation

Micro- and nano-plastics (MNPs) can enter the human body through inhalation, ingestion, contact with consumer products, and iatrogenic routes. The clinical relevance of MNP exposure should be interpr...

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🔍Researchers at Xi’an Jiaotong University provide a comprehensive overview of nanopore direct RNA sequencing (DRS), highlighting how the technology is changing transcriptomics and epitranscriptomics. onlinelibrary.wiley.com/doi/10.1002/...

Antiviral defense systems drive persistence of antimicrobial‐resistant bacteria but limit the transfer of antimicrobial resistance genes in anaerobic digestion onlinelibrary.wiley.com/doi/10.1002/...

Antiviral defense systems drive persistence of antimicrobial‐resistant bacteria but limit the transfer of antimicrobial resistance genes in anaerobic digestion

Phage–host interactions critically shape environmental antimicrobial resistance (AMR). Using swine manure anaerobic digestion and multi-omics (metagenomics, meta-transcriptomics, and Hi-C), we mapped....

onlinelibrary.wiley.com

From prediction to actionable mechanisms: Explainable multi‑omics AI for farm‑to‑fork postharvest preservation 🚀Unveiling causal drivers of food quality loss through explainable multi-omics AI. doi.org/10.1002/imt2...

From prediction to actionable mechanisms: Explainable multi‑omics AI for farm‑to‑fork postharvest preservation

Graphical overview of explainable artificial intelligence (XAI) for farm-to-fork postharvest preservation. Postharvest deterioration accumulates across orchard, packhouse, refrigerated transportation...

doi.org

🐒Early gut microbial and metabolic dysregulation with subclinical cardiac alterations in a nonhuman primate model of Rett syndrome 🔬Multi-omics reveals early systemic disruption spanning the gut microbiome, metabolism, and cardiac function. doi.org/10.1002/imt2...

Early gut microbial and metabolic dysregulation with subclinical cardiac alterations in a nonhuman primate model of Rett syndrome

Longitudinal multi-omics profiling of a nonhuman primate Rett syndrome (RTT) model reveals early systemic alterations. RTT monkeys exhibited postnatal growth retardation, intestinal structural abnorm...

doi.org