Maternal and infant gut microbiome

The maternal–infant continuum involves critical windows of host–microbiota co-adaptation. Preconception, maternal and paternal microbiomes modulate immunity and reproduction. During pregnancy, a gut–...

onlinelibrary.wiley.com

The plant microbiome: From ecological foundations to precision microbial engineering for sustainable agriculture

From ecological principles to precision engineering of plant microbiomes for sustainable agriculture. The plant holobiont integrates diverse microbial niches (including rhizosphere, endosphere, phyll...

onlinelibrary.wiley.com

Beyond omics: From descriptive profiling to causal and scalable design of fermentation microbiomes

Fermentation microbiomes play essential roles in food production, feed preservation, waste valorization, and diverse sustainable industrial processes. Although multi-omics and systems biology have su...

onlinelibrary.wiley.com

Bazi Bushen Capsule restores fertility by targeting mitochondrial health in aging endometrium

Bazi Bushen Capsule (BZBS) mitigates age-related endometrial dysfunction by activating AMPK − SIRT3 signaling. Luteolin, a key bioactive component, restores mitochondrial homeostasis via PINK1/Parkin...

onlinelibrary.wiley.com

Exposure to micro‐ and nano‐plastics: From human internal burden to systems‐level health‐risk interpretation

Micro- and nano-plastics (MNPs) can enter the human body through inhalation, ingestion, contact with consumer products, and iatrogenic routes. The clinical relevance of MNP exposure should be interpr...

onlinelibrary.wiley.com

Antiviral defense systems drive persistence of antimicrobial‐resistant bacteria but limit the transfer of antimicrobial resistance genes in anaerobic digestion

Phage–host interactions critically shape environmental antimicrobial resistance (AMR). Using swine manure anaerobic digestion and multi-omics (metagenomics, meta-transcriptomics, and Hi-C), we mapped....

onlinelibrary.wiley.com

From prediction to actionable mechanisms: Explainable multi‑omics AI for farm‑to‑fork postharvest preservation

Graphical overview of explainable artificial intelligence (XAI) for farm-to-fork postharvest preservation. Postharvest deterioration accumulates across orchard, packhouse, refrigerated transportation...

doi.org

Early gut microbial and metabolic dysregulation with subclinical cardiac alterations in a nonhuman primate model of Rett syndrome

Longitudinal multi-omics profiling of a nonhuman primate Rett syndrome (RTT) model reveals early systemic alterations. RTT monkeys exhibited postnatal growth retardation, intestinal structural abnorm...

doi.org

Synthetic microbial communities for engineering climate‐smart biofertilizers

Global agricultural productivity is increasingly destabilized by climate change—driven droughts, floods, extreme heat, and severe storms. Although the climate-smart agriculture (CSA) framework addres...

onlinelibrary.wiley.com

The role of human microbiota in breast cancer pathogenesis and treatment

The human microbiota contributes to breast cancer pathogenesis and treatment response through interactions involving the oral, gut, and breast microbial niches. (Left) Multi-site dysbiosis is charact...

doi.org

Decidual macrophage‐mediated ferroptosis in trophoblasts leads to recurrent spontaneous abortion

Decidual macrophages from recurrent spontaneous abortion (RSA) patients promote trophoblast ferroptosis and impair trophoblast cell function. Mechanistically, the CXCL2/NF-κB/HMOX1 axis mediates this...

doi.org

A spatiotemporal single‐cell atlas of porcine development reveals regulatory dynamics and cellular targets of domestication

This study presents a cross-tissue, single-cell/single-nucleus transcriptomic atlas spanning from prenatal to postnatal developmental stages in pig, characterizing 83 distinct cell types from 252,033...

onlinelibrary.wiley.com

Microbial keystone taxa and metabolic signatures in centenarians regulate intestinal homeostasis during aging

Clostridium scindens and its metabolite indole-3-acetic acid (IAA) are identified as a keystone taxon and metabolic signature in centenarians. Clostridium scindens enhances microbial network stabilit...

onlinelibrary.wiley.com

microeco 2: A comprehensive R package for downstream analysis of microbiome omics data

The current version 2.0 of the microeco package represents a substantial update compared to the previously published version. Key enhancements include the addition of new classes, integration of a br...

onlinelibrary.wiley.com

Patient‐derived organoid‐immune co‐cultures integrated with multi‐omics reveal immunotherapy resistance mechanisms in urothelial carcinoma

Immunotherapy resistance presents a formidable challenge in tumor biology. While fibroblast growth factor receptor 3 (FGFR3) serves as a pivotal oncogenic driver in a multitude of cancers, the explor...

onlinelibrary.wiley.com

Integrative host–microbiome modeling uncovers the implication of oral–gut translocation in advanced cirrhosis

Liver cirrhosis is associated with profound disruption of host–microbiome metabolic interactions. Using paired oral and fecal metagenomics combined with genome-scale metabolic modeling, we investigat...

onlinelibrary.wiley.com

Spinal cord injury induces acute microbiome shock and system‐wide transcriptomic reprogramming

This study investigates the systemic consequences of spinal cord injury (SCI), with a particular focus on alterations in the gut microbiome and multi-organ transcriptomic responses. We identify a rap...

onlinelibrary.wiley.com

FluNexus: A versatile web platform for antigenic prediction and visualization of influenza A viruses

FluNexus is a versatile platform for the antigenic prediction and visualization of influenza A viruses, including: (i) Online data preprocessing module. (ii) Online antigenic prediction module. (iii)....

onlinelibrary.wiley.com