Wafik S. El-Deiry, MD, PhD, FACP
@weldeiry.bsky.social
Physician-Scientist Oncologist, Director Legorreta Cancer Center, Associate Dean, past Faculty Exec Cmte member, Brown Univ, ACS Professor, Chair, WIN Consortium in Precision Oncology, Entrepreneur, Boat Captain, joined Nov 16 ‘24 Pubs: tinyurl.com/s98xg3u
Family sounds alarm after 83-year-old grandma dies under Canada's assisted-death program www.foxnews.com/media/family...
Family sounds alarm after 83-year-old grandma dies under Canada's assisted-death program
Brigitte Stegemann's granddaughter alleges the 83-year-old became distraught and said she "made a mistake" days before her MAiD procedure in Ontario.
foxnews.com
First-line fecal microbiota transplantation for the management of immune checkpoint inhibitor-mediated diarrhea and colitis www.cell.com/cell-reports...
First-line fecal microbiota transplantation for the management of immune checkpoint inhibitor-mediated diarrhea and colitis
Wang et al. report the efficacy of a preliminary cohort of patients who receive first-line fecal microbiota transplantation for the management of immune-mediated diarrhea and colitis with multi-omics ...
cell.com
I enjoyed as part of my role as a physician writing prescriptions by hand for patients until it was no longer the way medicine is practiced in the US.
Inhibitory circuits restrain adult glioma progression by suppressing calcium-driven oncogenic programs www.cell.com/neuron/abstr...
Inhibitory circuits restrain adult glioma progression by suppressing calcium-driven oncogenic programs
Uesaka et al. show that inhibitory brain circuits can suppress adult glioma growth by limiting tumor calcium signaling and downstream growth programs. The study reframes glioma progression as a balanc...
cell.com
The neurons that can put a brake on a nervous-system cancer Drugs that imitate the effect of GABAergic neurons slow the growth of tumours called gliomas in mice. x.com/nature/statu...
x.com
Tambotatug Pelitecan in Small-Cell Lung Cancer after Platinum-Based Therapy x.com/nejm/status/...
x.com
A targetable dependency on nonsense-mediated decay for cellular homeostasis and immune control in small cell lung cancer link.springer.com/article/10.1...
A targetable dependency on nonsense-mediated decay for cellular homeostasis and immune control in small cell lung cancer - Molecular Cancer
Small cell lung cancer (SCLC) is one of the most aggressive malignancies, characterized by rapid metastatic dissemination and poor overall survival. Despite harboring excessive alterations, expectedly...
link.springer.com
Early detection of invasive lung cancer and multiorgan metastasis by a collagen-targeted protein MRI contrast agent www.science.org/doi/10.1126/...
Early detection of invasive lung cancer and multiorgan metastasis by a collagen-targeted protein MRI contrast agent
Lung cancer with multiorgan metastasis remains the leading cause of cancer death. Current CT imaging and biopsy are suboptimal for detecting early tumors or subclinical metastases. We address this gap...
science.org
Working on important manuscripts today in pursuit of novel cancer treatments and strategies for precision cancer therapeutics. There is so much to be done In oncology and cancer research.
Top AI leaders unite to warn the technology is advancing too fast Dario Amodei, Sam Altman and Elon Musk, long at odds with each other, found common ground in calling for a slowdown in AI amid mounting fears about its dangers. www.washingtonpost.com/technology/2...
Top AI leaders unite to warn the technology is advancing too fast
Dario Amodei, Sam Altman and Elon Musk, long at odds with each other, found common ground in calling for a slowdown in the advancement of AI amid mounting fears about its dangers.
washingtonpost.com
Machine Learning–Designed Individualized Neoantigen Therapy Improves Recurrence-Free Survival in Resected Melanoma ascoai.org/articles/202...
Machine Learning–Designed Individualized Neoantigen Therapy Improves Recurrence-Free Survival in Resected Melanoma
ascoai.org
Targeting tumor-associated macrophages using mRNA lipid nanoparticles for cytotoxic T lymphocyte–mediated cancer immunotherapy www.science.org/doi/10.1126/...
Targeting tumor-associated macrophages using mRNA lipid nanoparticles for cytotoxic T lymphocyte–mediated cancer immunotherapy
The immunosuppressive tumor microenvironment (TME) remains one of the main obstacles that limit responsiveness to immunotherapy. Recently, lipid nanoparticles carrying messenger RNA (mRNA) have emerge...
science.org
Targeted mRNA Nanoparticles Turn Tumor Macrophages Against Cancer www.insideprecisionmedicine.com/topics/oncol...
Targeted mRNA Nanoparticles Turn Tumor Macrophages Against Cancer
Targeted mRNA nanoparticles reprogrammed tumor-associated macrophages and increased the infiltration and activity of cancer-fighting T cells in mice.
insideprecisionmedicine.com
IL1RAP-expressing myeloid-stromal networks represent a therapeutic vulnerability to improve chemoimmunotherapy sensitivity in pancreatic cancer insight.jci.org/articles/vie...
JCI Insight - IL1RAP-expressing myeloid-stromal networks represent a therapeutic vulnerability to improve chemoimmunotherapy sensitivity in pancreatic cancer
insight.jci.org
Scientists find a way to break pancreatic cancer’s protective shield www.sciencedaily.com/releases/202...
Scientists find a way to break pancreatic cancer’s protective shield
Researchers found that blocking IL1RAP could disrupt a powerful inflammatory network that helps pancreatic cancer survive treatment. In preclinical experiments, the approach reduced tumor-protecting c...
sciencedaily.com
Cancer treatment alters mutant selection in normal esophagus www.nature.com/articles/s41...
Cancer treatment alters mutant selection in normal esophagus - Nature Genetics
Cancer treatment alters the selection of preexisting somatic mutations in the normal esophagus, including druggable mutants that confer treatment resilience to normal cells.
nature.com
Global Precision Oncology meeting👇 Upcoming @WIN_Consortium Symposium in Providence, RI October 2-3, 2026. mcigroup-winsymposium2026.eventsairsite.com
U.S. cancer institute director counters gloomy forecast Anthony Letai denies political interference during his first year and says NCI's grant numbers are up again www.science.org/content/arti...
U.S. cancer institute director counters gloomy forecast
Anthony Letai denies political interference during his first year and says NCI's grant numbers are up again
science.org
Political world erupts as AI researchers warn of ‘extinction’ threat Anthropic has built its reputation as the safety-minded AI company. But some of its own researchers fear the race it has joined could end with humanity’s destruction. www.washingtonpost.com/technology/2...
Political world erupts as AI researchers warn of ‘extinction’ threat
Anthropic has built its reputation as the safety-minded AI company. But some of its own researchers fear the race it has joined could end with humanity’s destruction.
washingtonpost.com
Attended, as Secretary of the Faculty, the first university-wide faculty meeting for the academic year at on Brown’s College Hill campus in Providence, RI. The meeting had a celebratory tone with newly appointed and promoted faculty. Exciting year up ahead at @BrownUniversity which brings me hope.
“But if you're a researcher and you just watched this happen, I don't think you'd keep your best ideas inside someone else's product.” OpenAI fought dirty on career-making math problem, says NYU mathematician techcrunch.com/2026/09/08/o...
OpenAI fought dirty on career-making math problem, says NYU mathematician | TechCrunch
There is a $1 million bounty for the first person providing a solution to the Navier-Stokes existence and smoothness problem.
techcrunch.com
Research brings hope for precision cancer therapy. @WIN_Consortium
Laser Interstitial Thermal Therapy for Brain Tumors: A Prospective Multicenter Analysis of Patients From the LAANTERN Study ascopubs.org/doi/10.1200/...
Laser Interstitial Thermal Therapy for Brain Tumors: A Prospective Multicenter Analysis of Patients From the LAANTERN Study
PURPOSELaser interstitial thermal therapy is a surgical tool used to ablate brain tumors, radiation necrosis, and epileptic foci. Data from the LAANTERN prospective multicenter registry (ClinicalTrial...
ascopubs.org
Novartis Pauses Autoimmune CAR-T Cell Therapy Studies After Deaths Bristol-Myers Squibb also pauses similar trials as a precautionary measure www.wsj.com/health/pharm...
Novartis Pauses Autoimmune Cell Therapy Studies After Deaths
Novartis paused eight clinical trials of an experimental therapy targeting autoimmune and neurological disorders in late August, after three patients died.
wsj.com
Cruising Rhode Island waters on a Sunday, Summer 2026.
I don't believe that most science is fraudulent as I have said before. To believe otherwise is misguided and misleads both the public and regulators.
It is notable to hear Dr. Ashish Jha say he now believes the COVID pandemic was most likely the result of a lab leak. And it is also important to hear him say that gain-of-function research is a global issue that should be addressed as such. I fully agree. x.com/ashishkjha/s...
Ashish K. Jha (@ashishkjha) on X
On @CNNSOTU with @DanaBashCNN this morning. I said three things: 1. Political leaders are accountable for public health decisions, not the scientists who advise them 2. The vaccine-autism question h...
x.com
Concerned about the future of science in America.
I will disconnect at this time. Social Media takes too much of my precious time. Any time I have I would like to invest in science and medicine. And any posts will be strictly focused on discoveries and advances in cancer research and oncology. Thank you.
Here are images of two cancers that developed in the injected arm after COVID mRNA injections; lymphoma and sarcoma. link.springer.com/article/10.1... pmc.ncbi.nlm.nih.gov/articles/PMC...
