Intermittent #ThetaBurst stimulation targeting the dorsomedial prefrontal cortex enhanced placebo-induced mood improvement by potentiating default mode network activity in adults with depressive symptoms. ja.ma/4tUonkm
Helmet Karim
@helmetkarim.bsky.social
Assistant professor of Psychiatry and Bioengineering at University of Pittsburgh
Very excited to share new findings from an NIMH-funded R21 on the neurodevelopment of worry! Manuscript led by super 🌟 Postdoctoral Scholar in the lab @ceciwestbrook.bsky.social , check it out! 👇👇👇 @psychiatry.pitt.edu
@ceciwestbrook.bsky.social · 6mo ago!! New publication alert !! Identifying neurodevelopmental signatures of worry: An ultra-high field (7-Tesla) fMRI study among adolescents and young adults www.sciencedirect.com/science/arti... @cdladouceur.bsky.social @antonija-kolobaric.bsky.social @helmetkarim.bsky.social
!! New publication alert !! Identifying neurodevelopmental signatures of worry: An ultra-high field (7-Tesla) fMRI study among adolescents and young adults www.sciencedirect.com/science/arti... @cdladouceur.bsky.social @antonija-kolobaric.bsky.social @helmetkarim.bsky.social
Identifying neurodevelopmental signatures of worry: An ultra-high field (7-Tesla) fMRI study among adolescents and young adults
Worry plays an important role in anxiety disorders, but its neurodevelopment remains unclear. Worry increases during adolescence when cognitive-affect…
sciencedirect.com
Pitt Psychiatry had lots of good news from @acnporg.bsky.social, including awards and new memberships! See our story here: bit.ly/4jW2lK3
Congratulations to Angela Ianni, MD, DPhil, who has been selected for the Member in Training Award by the AAGP! Dr Ianni’s research focuses on the neural processes underlying suicidal behavior in late-life depression. bit.ly/4stLzpv
In JAMA Psychiatry, scientists including Kristen Eckstrand, MD, PhD, discuss the psychiatric and ethical concerns raised by care denial for transgender youth: jamanetwork.com/journals/jam...
Pitt Psychiatry investigators have recently published research studies on mental health in late life in Alzheimer’s & Dementia, Nature Communications, and Neuropsychopharmacology. See more from Minjie Wu, PhD; Tharick Pascoal, MD, PhD; Helmet Karim, PhD; and Carmen Andreescu, MD: bit.ly/3KziYxR
Preprint is now published: doi.org/10.1002/hbm.... Special thanks to co-authors @twktan.bsky.social @kimnganngt.bsky.social @csabaorban.bsky.social
Mind the Gap: Does Brain Age Improve Alzheimer’s Disease Prediction?
We compared large-scale brain age models versus models trained from scratch to predict specific brain health outcomes (i.e., direct models) in the context of Alzheimer disease dementia. Our results e....
doi.org
Thomas Yeo@bttyeo.bsky.social · 2y ago🚨 Brain Age vs Direct Models in Alzheimer’s disease (AD) 🚨 A thread 🧵 1/ Brain age is a powerful indicator of general brain health, trained on massive datasets. But does this translate to better prediction for specific outcomes, like AD? Preprint by @twktan.bsky.social : doi.org/10.1101/2024...
Excellent commentary from Haroon & Miller on our REMBRANDT late-life depression study led by Andrew Gerlach (www.nature.com/articles/s41...) www.nature.com/articles/s41...
This study explored relapse & recurrence in late-life depression, finding widespread 🧠 network configuration was required for resilience, while failure to reconfigure was associated w/ vulnerability to relapse www.nature.com/artic...
Network homeostasis: functional brain network alterations and relapse in remitted late-life depression
Neuropsychopharmacology - Network homeostasis: functional brain network alterations and relapse in remitted late-life depression
nature.com
A recent study investigated the role of repetitive transcranial magnetic stimulation (rTMS) in sustaining remission in patients with treatment-resistant depression. Full article: jamanetwork.com/journals/jam...
A recent study explored the effects of low-intensity transcranial focused ultrasound (LIFU) on amygdala activation during emotional processing. Utilizing MRI-guided LIFU, researchers aimed to modulate the amygdala's response to emotional stimuli.
New finding! 5-day accelerated TMS (no MRI needed) showed major PTSD symptom relief in n~100 Veterans—77% response, 62% remission. Fast, scalable, and effective with scalp-based targeting. A big step for accessible PTSD care. 👉 www.sciencedirect.com/science/arti... #TMS #PTSD
Pragmatic Accelerated Transcranial Magnetic Stimulation for Posttraumatic Stress Disorder
sciencedirect.com
I encourage everyone to visit this site 5calls.org/all/. Make your calls to your representatives to make your voice heard. Highly encourage everyone to call about recent scientific funding changes: 5calls.org/issue/nih-ns....
All topics ⭑ 5 Calls
Spend 5 minutes. Make 5 calls. Make your voice heard.
5calls.org
New essay on NIH and indirect costs: goodscience.substack.com/p/indirect-c...
Indirect Costs at NIH . . .
I wasn’t planning on spending part of a Saturday writing about cost accounting principles and the like, but NIH-world was hit with a doozy of a policy announcement on Friday night:
goodscience.substack.com
Instead of cutting costs for working families, Donald Trump is slashing the federal investments that fund their lifesaving care, fuel their local economy, and lower their health care costs. It’s cruel, short-sighted, and will cost jobs and devastate millions of families.
NIH cuts billions of dollars in biomedical funding, effective immediately
Researchers say it would hurt facilities that work on medical issues such as cancer research and heart disease. Elon Musk contends the old policy was ‘a ripoff.’
washingtonpost.com
Another banger from the REMBRANDT study! www.nature.com/articles/s41...
Brain and cardiovascular responses to acute stress in remitted and recurrent late-life depression - Neuropsychopharmacology
Neuropsychopharmacology - Brain and cardiovascular responses to acute stress in remitted and recurrent late-life depression
nature.com
Felix’ story is devastating, relatable, and underlines why we should be concerned about psychedelic hype: www.paperlesspost.com/go/7BbrzXXhb...
You're invited to "Farewell, Felix." Tap here to RSVP - Paperless Post Flyer
We are all devastated by Felix’s untimely death on 5th December 2024. He had been struggling with severe mental illness since early 2023. There will be a funeral on 11th January in north London which...
paperlesspost.com
Hi all! This is Layla Banihashemi, Associate Professor of Psychiatry & BioE at Pitt. I'm a neuroscientist researching stress-control circuits and their relationships with adversity & trauma. Come find me All the way in the back (😄) at poster W300 sharing new data from our 7T R01 study! #ACNP2024
Neuropsychopharmacology@npp-journal.bsky.social · 2y agoWe are officially on the ground in Phoenix so it's time for the #ACNP2024 role call 📣 Introduce yourself, your science, tell us if you're a veteran or first-timer, promote your poster/talk/favorite social - whatever you want, this is your space to say it ⬇️
Hey #ACNP2024, come check out our poster tonight (M78) on using cTBS to modulate nucleus accumbens to dmPFC connectivity and its effects on positive affect. See our blue sky poster (it's a 1 minute gif)!
Hey #ACNP2024, I’m Andrew Gerlach, Asst. Prof. of psychiatry at Pitt studying late life depression and anxiety, primarily with MRI. If you’re still around on Wednesday afternoon, stop by poster 82 to chat about the intrinsic networks and involved in antidepressant placebo response!
Neuropsychopharmacology@npp-journal.bsky.social · 2y agoWe are officially on the ground in Phoenix so it's time for the #ACNP2024 role call 📣 Introduce yourself, your science, tell us if you're a veteran or first-timer, promote your poster/talk/favorite social - whatever you want, this is your space to say it ⬇️
Hi I'm Helmet Karim, I'm an assistant professor of Psychiatry at U. Of Pittsburgh. Come see my hot topics talk at 5p tonight or my poster M78 on dmpfc TMS!
Neuropsychopharmacology@npp-journal.bsky.social · 2y agoWe are officially on the ground in Phoenix so it's time for the #ACNP2024 role call 📣 Introduce yourself, your science, tell us if you're a veteran or first-timer, promote your poster/talk/favorite social - whatever you want, this is your space to say it ⬇️
Excited for @helmetkarim.bsky.social ‘s hot topic talk on TMS at #ACNP2024!
✨Our paper is out in Nature today! ✨ In this work, we investigated how we can leverage study designs to improve the replicability of brain-wide association studies (BWAS) 👇👇👇 www.nature.com/articles/s41...
Study design features increase replicability in brain-wide association studies - Nature
Optimizing study design is critical for increasing standardized effect sizes and replicability, and the features that increase replicability in cross-sectional and longitudinal brain-wide association ...
nature.com
Loneliness is one critical risk factor for cognitive health 👇 www.nature.com/articles/s44...
A meta-analysis of loneliness and risk of dementia using longitudinal data from >600,000 individuals - Nature Mental Health
Using data from large longitudinal observational studies, the authors conducted a meta-analysis to investigate the association between loneliness and dementia.
nature.com