Tessera
Folgen

Singleron Biotechnologies

@singleronbio.bsky.social

From single cell multi-omics to precision medicine

43 Posts20 Follower2 Folgt
Singleron Biotechnologies@singleronbio.bsky.social · last yr.

MIRO1 and #Parkinson’s: #singlecell #RNAseq and metabolic modeling of #organoids linked MIRO1 p.R272Q mutation to metabolic deficits and disrupted neuron-astrocyte metabolic crosstalk. Singleron GEXSCOPE kit used. www.nature.com/articles/s41...

MIRO1 mutation leads to metabolic maladaptation resulting in Parkinson’s disease-associated dopaminergic neuron loss - npj Systems Biology and Applications

npj Systems Biology and Applications - MIRO1 mutation leads to metabolic maladaptation resulting in Parkinson’s disease-associated dopaminergic neuron loss

nature.com

Singleron Biotechnologies@singleronbio.bsky.social · 2y ago

A single-cell resolved genotype-phenotype map using genome-wide genetic and environmental perturbations: Singleron GEXSCOPE Single Yeast Kit used in this exciting study.

A single-cell resolved genotype-phenotype map using genome-wide genetic and environmental perturbations - Nature Communications

Heterogeneity determines cell fate and phenotypic variability, but its molecular mechanisms are not well understood. Here the authors present a high-resolution single-cell yeast transcriptome atlas of...

nature.com

Singleron Biotechnologies@singleronbio.bsky.social · 2y ago

Turns out, the old saying is true—your gut really does rule your world! This interesting study shows that social rank shapes gut microbes, which in turn influence brain function and behavior. Singleron Single Nucleus RNAseq kit used.

Perturbations in the microbiota-gut-brain axis shaped by social status loss - Communications Biology

The PI3K-Akt signaling pathway of the microbiotagut-brain axis is involved in forced loss induced by forced reduction of social rank in mice, and influences the outcome of forced loss.

nature.com

Singleron Biotechnologies@singleronbio.bsky.social · 2y ago

A Mayo Clinic study shows that preoperative #MRA associated with 40% reduction in POAF/41% lower AF. #snRNA using Singleron product suggests that canrenone added to cardiac preservation solution inhibits pahways related to chronic AF.   www.biorxiv.org/content/10.1... www.biorxiv.org/content/10.1...

Mineralocorticoid Receptor Antagonism Reduces Atrial Arrhythmias Post-Cardiac Surgery and Attenuates Atrial Stress Responses to Cardioplegic Arrest

Background New postoperative atrial fibrillation (POAF) occurs in about 40% after cardiac surgery. Mineralocorticoid receptor antagonists (MRA) are known to reduce chronic atrial fibrillation (AF) dev...

biorxiv.org

Singleron Biotechnologies@singleronbio.bsky.social · 2y ago

Improved method to detect nascent RNA at single cell resolution, developed by Singleron scientist + collaborators pubmed.ncbi.nlm.nih.gov/39908452/

In Vivo Time-Resolved Single-Cell RNA-Seq Reveals Chemotherapy-Induced Transcriptional Dynamics in Tumor Infiltrating Lymphocytes - PubMed

Single-cell RNA sequencing (scRNA-seq) using metabolic RNA labeling enables detailed analysis of dynamic gene expression within single cells. However, most studies are limited to in vitro settings, re...

pubmed.ncbi.nlm.nih.gov

Singleron Biotechnologies@singleronbio.bsky.social · 2y ago

Immune evasion through mitochondrial transfer in the tumour #microenvironment : intriguing cellular interactions in cancer www.nature.com/articles/s41...

Immune evasion through mitochondrial transfer in the tumour microenvironment - Nature

Mitochondria with mutations in their DNA from cancer cells can be transferred to T cells in the tumour microenvironment, which leads to T cell dysfunction and impaired antitumour immunity.

nature.com

Singleron Biotechnologies@singleronbio.bsky.social · 2y ago

Dual targeting PD-L1 and 4-1BB to overcome dendritic cell-mediated lenalidomide resistance in follicular #lymphoma - and #singlecell sequencing helped to understand how. Singleron GEXSCOPE used in this clinical study.

Dual targeting PD-L1 and 4-1BB to overcome dendritic cell-mediated lenalidomide resistance in follicular lymphoma - Signal Transduction and Targeted Therapy

Signal Transduction and Targeted Therapy - Dual targeting PD-L1 and 4-1BB to overcome dendritic cell-mediated lenalidomide resistance in follicular lymphoma

nature.com

Singleron Biotechnologies@singleronbio.bsky.social · 2y ago

#Single-nuclei #RNAseq to revealed auxin-driven mechanisms of wood plasticity and severe drought tolerance in poplar. Singleron GEXSCOPE used for this #plant study.

Single-nuclei transcriptomics revealed auxin-driven mechanisms of wood plasticity and severe drought tolerance in poplar

Drought significantly affects forests and woody crops by limiting their growth, increasing their susceptibility to diseases, and reducing productivity. Wood anatomical plasticity is a crucial adaptive...

biorxiv.org

Singleron Biotechnologies@singleronbio.bsky.social · 2y ago

Recent #singlecell models enable deeper insights into the ever growing wealth of data. Recently published GET is a generalizable and accurate model for transcription, gene regulation and transcription factor interactions, all with cell type specificity.

A foundation model of transcription across human cell types - Nature

A foundation model learns transcriptional regulatory syntax from chromatin accessibility and sequence data across a range of cell types to predict gene expression and transcription factor interactions...

nature.com

Singleron Biotechnologies@singleronbio.bsky.social · 2y ago

A*STAR researchers found that nanoparticles can induce arrhythmia in human stem-cells derived cardiomyocytes - Singleron’s AccuraCode High-Throughput RNA Library Kit was used to analyze transciptome changes. www.sciencedirect.com/science/arti...

Nanoplastics induces arrhythmia in human stem-cells derived cardiomyocytes

Nanoplastics (NPs), plastic particles ranging from 1–1000 nm, form through weathering and are considered more hazardous than larger plastics due to th…

sciencedirect.com