Excited to share our new paper! This was a fun project, and I’m grateful to all who made it possible! 🧬😊

Woodson Lab@woodsonlab.bsky.social · 4mo ago

Our new paper is out! Using 19F NMR, we show that Hfq rewires the conformational dynamics of a model sRNA in a site-specific manner. Uridines at the rim undergo faster exchange (~100 μs) than those in the proximal pore (~300 μs). Congrats Elise! 🎉🎉 www.sciencedirect.com/science/arti...

Our new paper is out! Using 19F NMR, we show that Hfq rewires the conformational dynamics of a model sRNA in a site-specific manner. Uridines at the rim undergo faster exchange (~100 μs) than those in the proximal pore (~300 μs). Congrats Elise! 🎉🎉 www.sciencedirect.com/science/arti...

19F NMR Strategy for Probing Site-specific RNA Dynamics in Large RNA-protein Complexes: Application to the Hfq RNA Chaperone

Nuclear magnetic resonance (NMR) spectroscopy is uniquely suited to probing motions on the microsecond to millisecond timescales that underlie RNA rec…

sciencedirect.com

Review by the Mühlemann Lab with first author Wojciech Teodorowicz "Molecular determinants and therapeutic targeting of stop codon readthrough in eukaryotic translation" @jmolbiol.bsky.social nccr-rna-and-disease.ch/news/article... @omuhlemann-lab.bsky.social @unibe.ch

Publication by the Gatfield and Jonas labs with co-first authors Enes Arpa and Michael Taschner "Active Site Assembly by SMG5 as a Mechanism for SMG6 Endonuclease Licencing in Nonsense-mediated mRNA Decay" @jmolbiol.bsky.social nccr-rna-and-disease.ch/news/article... @unil.bsky.social @ethz.ch

A nice X-mas present with finally accepted story on the PDZK1 and URAT1 interaction in @jmolbiol.bsky.social A lot of work not only from me and @chriswir.bsky.social, but also from several undergrad students! The study is a part of @sfb1453.bsky.social project.

Christophe Wirth@chriswir.bsky.social · 7mo ago

Happy to share our paper in the frame of the @sfb1453.bsky.social project that got published in @jmolbiol.bsky.social Tremendous work from @emymrikov.bsky.social and others, on how the scaffold protein PDZK1 interacts with the urate transporter URAT1. ⬇️ www.sciencedirect.com/science/arti...

🚨 Just in press @jmolbiol.bsky.social 🚨 Kate, Candice, and Mark's paper on the structure of the V. cholerae NFeoB NTPase catalytic cycle. Serendipity of a P1 spacegroup with 4 mols in the ASU played a role in capturing all the states, and Mg is pivotal! Read the paper here: tinyurl.com/mr3dmmjz

The structure of the full catalytic cycle of Vibrio cholerae NFeoB

The acquisition of iron is critical for the survival and the virulence of numerous infectious pathogens, and most bacteria acquire ferrous iron (Fe2+)…

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Conservation and specificity in Bacillus biofilm dynamics: on structure and function of B. cereus Camelysins [CalY = TasA-like protein] @jmolbiol.bsky.social from Hartmut Oschkinat www.sciencedirect.com/science/arti...

Conservation and specificity in Bacillus biofilm dynamics: on structure and function of B. cereus Camelysins

The B. cereus family comprises members highly pathogenic for mammals or insects, with B. anthracis and B. thuringiensis respectively as notable exampl…

sciencedirect.com

Happy to share our paper in the frame of the @sfb1453.bsky.social project that got published in @jmolbiol.bsky.social Tremendous work from @emymrikov.bsky.social and others, on how the scaffold protein PDZK1 interacts with the urate transporter URAT1. ⬇️ www.sciencedirect.com/science/arti...

Molecular Determinants of Selective and High-affinity Binding of the Scaffold Protein PDZK1 to the Urate Transporter URAT1

The renal solute carrier URAT1 (SLC22A12) is essential for urate homeostasis, with loss-of-function linked to renal hypouricemia, nephrolithiasis and …

sciencedirect.com

PDBe-KB Complexes has been published in @jmolbiol.bsky.social at the start of the new year, introducing a complex centric view of experimentally determined macromolecular assemblies in the PDB. 📄 Read the paper: sciencedirect.com/science/arti... #PDBeKB #MacromolecularComplex #Bioinformatics

PDBe-KB Complexes: Enabling Functional Insight from Macromolecular Complexes in the PDB

PDBe-KB Complexes is a set of webpages that aggregate experimentally determined macromolecular assemblies into unique complex-level records within the…

sciencedirect.com

How is AI changing publishing? Join Calvin Chan from Biochemistry and Cell Biology and Danie Descoteaux from Journal of Molecular Biology on Dec. 16 at 8:30 AM PST for insights on opportunities, risks, and best practices. Hosted by @csmb-scbm.bsky.social. Register: https://ow.ly/4FgR50XFJ4r

JMB Journal of Molecular Biology @jmolbiol.bsky.social Recent 19F NMR Applications to the Study of Membrane Proteins and Protein Complexes, Philip Drewniak, Celia Yi-Chia Su, Camila Botin Francisco, Robert Scott Prosser* @chemuoft.bsky.social www.sciencedirect.com/science/arti... #NMRchat 🧲

Recent 19F NMR Applications to the Study of Membrane Proteins and Protein Complexes

Fluorine Nuclear Magnetic Resonance (19F NMR) is a critical spectroscopic tool for studies of the dynamic conformational ensemble associated with prot…

sciencedirect.com

Our review on LGT / HGT Iin extremophiles is now available OA www.sciencedirect.com/science/arti...

Impact of Horizontal Gene Transfer on Adaptations to Extreme Environments

Horizontal (or lateral) gene transfer – an acquisition of genetic material not associated with the organismal reproduction – is known to alter genomes…

sciencedirect.com

[Review] Configuring the code: Enhancer-Promoter arrangement and transcriptional regulation in @jmolbiol.bsky.social #genesky www.sciencedirect.com/science/arti...

Configuring the Code: Enhancer-Promoter Arrangement and Transcriptional Regulation

The precise spatial and temporal regulation of gene expression through enhancer-promoter (E-P) interactions represents a fundamental mechanism underly…

sciencedirect.com

Delighted to see Jon Machin's lovely OMP folding and assembly work on the front cover of JMB (doi: 10.1016/j.jmb.2025.169346) and in this Faraday Discussion article (doi: 10.1039/d4fd00180). Congratulations on your great work Jonathan!

Excited to share our currently in-press article describing an improved dual-reporter system for real-time measurement of translational recoding across diverse cell types and contexts! @jmolbiol.bsky.social

An RNA-Based Dual-Fluorescence Reporter System Reveals Cell Type-Specific and Temporal Dynamics of −1 Programmed Ribosomal Frameshifting

Translational recoding events, such as programmed ribosomal frameshifting (PRF), are critical regulatory processes that enable the production of multi…

sciencedirect.com

Thrilled to share my latest review on the role of the #WIPI2 and #ATG16L1 complex in both selective and nonselective #autophagy 🔍🧬 It’s fascinating how these two forms of autophagy rely on the same core machinery, yet lead to such different outcomes. What defines this divergence? Have a look here 👀

The Role of WIPI2, ATG16L1 and ATG12-ATG5 in Selective and Nonselective Autophagy

Autophagy is a conserved cellular recycling pathway that delivers damaged or superfluous cytoplasmic material to lysosomes for degradation. In respons…

sciencedirect.com

Hello Bluesky! We are happy to join this growing platform to further engage with the JMB community. We are looking forward to highlighting your impactful scientific discoveries and sharing news about upcoming issues and opportunities. Please follow us and stay tuned for some exciting updates!