How can patients prepare for planned surgery? Daniel McIsaac and colleagues looks at the current prehabilitation science and practice, and explore the necessary steps to deliver effective prehabilitation before planned surgery. https://bit.ly/4i9hCbn

Prehabilitation in preparation for surgery

Prehabilitation transforms the preoperative waiting period into an opportunity for patients to actively improve their health before surgery. With surgical populations ageing and presenting with increa...

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Maximilian Siebert and colleagues evaluate the use of postmarketing requirements under the FDA Amendments Act and postmarketing commitments issued by the US FDA, for new drugs approved from 2016 to 2024. https://bit.ly/4qjgHas

Completion and outcomes of postmarketing requirements and commitments issued by the US Food and Drug Administration for new drugs, 2016-24: cross sectional evaluation of postmarketing studies

Objectives To evaluate the use of postmarketing requirements under the FDA Amendments Act (FDAAA) and postmarketing commitments issued by the US Food and Drug Administration (FDA), for new drugs appro...

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Uttara Partap and colleagues estimate the associations between gestational weight gain and maternal immediate perinatal and postpartum outcomes in low and middle income countries. Read now in BMJ Medicine: https://bit.ly/4x0XfC0

Gestational weight gain and maternal immediate perinatal and postpartum outcomes in low and middle income countries: individual participant data meta-analyses

Objective To estimate the associations between gestational weight gain and maternal immediate perinatal and postpartum outcomes by pooling data from low and middle income countries.Design Individual p...

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In their study, Carlos Sánchez-Soriano and colleagues find that one in eight mothers in England had a diagnosis of gestational diabetes between 2018-2022, and call for strategies to provide and improve care for this high risk group. https://bit.ly/45c7lne

A new study by Carlos Sánchez-Soriano and colleagues quantifies the incidence of gestational diabetes mellitus in England and examines inequalities in diagnosis and adverse pregnancy outcomes. Read now in BMJ Medicine: https://bit.ly/4z2AOhg #MaternalHealth

In their new study, Maximilian Siebert and colleagues evaluate the use of postmarketing requirements under the FDA Amendments Act and postmarketing commitments issued by the US FDA, for new drugs approved from 2016 to 2024. Read now in BMJ Medicine https://bit.ly/4yNktg6

Completion and outcomes of postmarketing requirements and commitments issued by the US Food and Drug Administration for new drugs, 2016-24: cross sectional evaluation of postmarketing studies

Objectives To evaluate the use of postmarketing requirements under the FDA Amendments Act (FDAAA) and postmarketing commitments issued by the US Food and Drug Administration (FDA), for new drugs appro...

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New research from Uttara Partap and colleagues estimates the associations between gestational weight gain and maternal immediate perinatal and postpartum outcomes in low and middle income countries. Read now in BMJ Medicine: https://bit.ly/45ncF76 #MaternalHealth

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Scientific progress depends on more than discovery. This editorial, published in Considerations in Medicine, makes the case for recognising replication, transparency, and methodological rigour as essential components of impactful research. Read it here: https://bit.ly/4fOl7mu

How does gestational weight gain impact maternal perinatal and postpartum outcomes? Uttara Partap and colleagues estimate the associations between gestational weight gain and maternal immediate perinatal and postpartum outcomes in low and middle income countries. https://bit.ly/4gAC5W2

Gestational weight gain and maternal immediate perinatal and postpartum outcomes in low and middle income countries: individual participant data meta-analyses

Objective To estimate the associations between gestational weight gain and maternal immediate perinatal and postpartum outcomes by pooling data from low and middle income countries.Design Individual p...

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A new review by Daniel McIsaac and colleagues looks at the current prehabilitation science and practice, and explore the necessary steps to deliver effective prehabilitation before planned surgery. https://bit.ly/4xWuw25

Daniel Belavý and colleagues examine the efficacy of non-surgical treatments for chronic radicular and non-specific back pain. In this study they found that while some treatments were effective for pain and function in the short term, improvements did not persist long term. https://bit.ly/4wmcXH0

Conservative treatments for chronic non-specific low back pain: time course network meta-analysis

Objective To examine the efficacy of conservative (non-surgical) treatments, usual care, and no treatment for chronic radicular and non-specific back pain.Design Time course network meta-analysis.Data...

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How effective are conservative (non-surgical) treatments for chronic non-specific low back pain? New research by Daniel Belavý and colleagues examines the efficacy of conservative treatments, usual care, and no treatment for chronic radicular and non-specific back pain. https://bit.ly/4gXIR8c

Conservative treatments for chronic non-specific low back pain: time course network meta-analysis

Objective To examine the efficacy of conservative (non-surgical) treatments, usual care, and no treatment for chronic radicular and non-specific back pain.Design Time course network meta-analysis.Data...

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Daniel McIsaac and colleagues highlights the effects of multimodal prehabilitation on improving clinical and patient centred outcomes. Combining exercise and nutrition offers the most effective route to better clinical outcomes for surgical patients. https://bit.ly/3Riprk1

There’s been a lot of hype about personalised medicine and the potential of polygenic risk scores to help prevent disease. High risk individuals can be identified from genetic testing and targeted with prevention strategies. But how effective is communicating this risk to people?

New research by Luigi Russo and colleagues finds disclosing polygenic risk scores does not result in meaningful change to patient health behaviours or outcomes. Despite promising claims, current RCT data shows limited impact on preventive measures https://bit.ly/4oBzxsE

Effects of polygenic risk score communication on short term health outcomes: systematic review and meta-analysis

Objective To summarise the evidence so far from all randomised controlled trials on the efficacy of communication of polygenic risk scores in changing health outcomes.Design Systematic review and meta...

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Scientific progress depends on more than discovery. This editorial, published in Considerations in Medicine, makes the case for recognising replication, transparency, and methodological rigour as essential components of impactful research. Read it here: https://bit.ly/4fOl7mu

Does disclosing polygenic risk scores change health outcomes? New research by Luigi Russo and colleagues summarises the evidence so far from all RCTs on the efficacy of communication of polygenic risk scores in changing health outcomes. https://bit.ly/3SnKPVa

Effects of polygenic risk score communication on short term health outcomes: systematic review and meta-analysis

Objective To summarise the evidence so far from all randomised controlled trials on the efficacy of communication of polygenic risk scores in changing health outcomes.Design Systematic review and meta...

bmjmedicine.bmj.com

A new review by Catrin Cox and colleagues discusses identifying and managing the coagulopathy of severe postpartum haemorrhage and reports on the new understanding of the haemostatic changes of postpartum haemorrhage Read the full review in BMJ Medicine: https://bit.ly/4amQQYo

Catrin Cox and colleagues examine new approaches in the haemostatic management of postpartum haemorrhage in this specialist review. https://bit.ly/4uyXHVU

Great thread on immortal time bias. Save the paper for your next journal club.

BMJ Medicine@bmjmedicine.bsky.social · 5mo ago

Immortal time bias in observational studies is common. A new BMJ Methods Primer from Harrison Hansford et al. explains what it is, and how to avoid it. 🧵https://bmjmedicine.bmj.com/content/5/1/e001280

The proposed new rules on federal funding are another blow to 🇺🇸 science But they will also harm international collaborations, the lifeblood of science and health 🌐 Where is the US medical leadership and outrage? My new piece @bmj_latest www.bmj.com/content/393/...

Laura Shannon and colleagues examine the pathogenesis of pulmonary fibrosis and link the evolving mechanistic insights to current and emerging therapeutic strategies in this review. Read now in BMJ Medicine: https://bit.ly/3REaoRH

A new review by Laura Shannon and colleagues examines the pathogenesis of pulmonary fibrosis and links evolving mechanistic insights to current and emerging therapeutic strategies. Read now in BMJ Medicine: https://bit.ly/3REaoRH

Delphine Mitanchez and colleagues assesses whether procalcitonin-guided decision making can safely reduce the duration of antibiotic treatment in neonatal late onset sepsis in newborns Read the full study in BMJ Medicine: https://bit.ly/3PILP5q

Yan Xie and colleagues assess whether initiation of GLP-1 receptor agonists rather than sulfonylureas is associated with all cause acute pancreatitis and cause specific acute pancreatitis Read in BMJ Medicine: https://bit.ly/49iTWfB

Georgina Nakafero and colleagues examine incidence of fragility fracture, atypical femoral fracture & osteonecrosis of the jaw after bisphosphonate prescription. Read the full paper in BMJ Medicine: https://bit.ly/4uIFTIE

In this study, Marc Raynaud and colleagues validate the integrative Box (iBox) prediction system for kidney allograft failure in real world settings and clinical scenarios https://bit.ly/4v4Oghx

A new randomised control trial by Delphine Mitanchez and colleagues assesses whether procalcitonin-guided decision making can safely reduce the duration of antibiotic treatment in neonatal late onset sepsis Read the full study in BMJ Medicine: https://bit.ly/3RvkAf0

Paul van Amstel and colleagues and colleagues compare non-operative treatment strategy with appendectomy for children with simple appendicitis, looking at complications, quality of life, and cost-effectiveness. Read the full study in BMJ Medicine: https://bit.ly/49FrPY1

How can we safely reduce antibiotic exposure in newborns with late onset sepsis? Delphine Mitanchez and colleagues investigates if procalcitonin-guided decision-making can safely reduce the duration of antibiotic treatment for neonatal late onset sepsis. https://bit.ly/42BXRQZ