💬 Viewpoint: In clinical high risk for developing #Psychosis, impaired social functioning is both a predictor of psychosis onset and a major source of disability, supporting trials that measure recovery with person-centered functional outcomes. ja.ma/4cgbuKz

Among #veterans with #PosttraumaticStressDisorder and distress related to killing in war, impact of killing psychotherapy improved psychosocial functioning and showed greater benefit than present-centered therapy present-centered therapy. ja.ma/4pTOmXW

📝 JAMA Psychiatry #Review: Peripheral #Biomarkers in #Psychiatry depend more on study design than on analytic sophistication, with signal most likely when studies reduce confounding, select reliable phenotypes, and match biomarker use to clinical need. ja.ma/4vU5bU0

💬 Viewpoint: In #Psychiatry, large language models should be used as clinical instruments, with clinician accountability and source-grounded verification before output influences care. ja.ma/4xcXbyL

Among adolescents in substance use disorder treatment who used nicotine #ECigarettes, urine cotinine concentrations increased abruptly beginning in October 2024. ja.ma/4hIXIUi

Among patients with prior #SexualViolence, hypervigilance remained the highest #PTSD symptom over time, while negative alterations in cognition and mood recovered most slowly. ja.ma/4wfUNXb

💬 Editor's Note by JAMA Psychiatry Editor in Chief Dost Ongur, MD, PhD: Delayed updates to the ja.ma/3S1Mznh record created a misleading impression that key protocol changes in a first-episode #Psychosis trial had been made retrospectively. ja.ma/4h3l8Uk

Failure to Update https://ja.ma/3S1Mznh Record for a Clinical Trial

JAMA Psychiatry published “Clozapine After 1 Failed Antipsychotic Drug Trial in First-Episode Psychosis: A Randomized Clinical Trial” by Li and colleagues on March 11, 2026.1 Following publication, our readers noted on social media and in personal communications that this study was initially...

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💬 Editorial: After medication abortion or procedural #Abortion, psychotropic medication prescribing was modestly higher in the following year, but the association should not be interpreted as causal. ja.ma/4h48Xqf

How Should We Interpret the Association Between Abortion and Mild Psychiatric Illness?

In this issue of JAMA Psychiatry, in a cohort study drawn from the Danish population registry, Steinberg et al1 concluded that neither medication abortion nor procedural abortion was associated with a statistically significant increase in the risk for psychotropic medication use after adjustment for...

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After medication or procedural #Abortion, small first-year increases in psychotropic medication prescription redemptions no longer met criteria for statistical significance after Bonferroni adjustment. ja.ma/4pHUMJA

Medication and Procedural Abortion and Risk of Psychotropic Medication Use

This population-based Danish registry cohort study examines whether medication abortions or procedural abortions were associated with increased risk of psychotropic medication use.

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Dan-Mircea Mirea, PhD, and John Torous, MD, discuss how receiving more “likes” on social media posts led to greater increases in posting among users with #depression compared to those without depression. 🎧 Listen now: ja.ma/4vs61HE

Military sexual trauma prevalence remains high among US veterans, especially females, and is associated with increased risk for suicidal thoughts and behaviors. ja.ma/44lGKDV

📄JAMA Psychiatry #Review: Functional unblinding was common in most #psychedelic randomized clinical trials for psychiatric disorders, with >70% correctly identifying treatment allocation, raising concerns for trial validity. ja.ma/4vSymHT

Systematic Review: Greater exposure to adverse #SocialDeterminants was associated with #neurobiological abnormalities in #Schizophrenia spectrum conditions, linking SDOHs to clinical outcomes and supporting equity-oriented approaches. ja.ma/4phhfNB

Targeted psychological and psychosocial interventions for #Schizophrenia, including avatar therapy, reduced the severity of #AuditoryHallucinations with small to medium effects and high acceptability. ja.ma/44lg06w

In #overweight or #obese patients with #Depression, adjunctive oral #semaglutide reduced effort discounting and improved motivation on a validated effort-expenditure task compared with placebo. ja.ma/4b5knX9

Targeted psychological and psychosocial interventions for #Schizophrenia, including avatar therapy, reduced the severity of #AuditoryHallucinations with small to medium effects and high acceptability. ja.ma/4wsgrIb

Systematic Review: Greater exposure to adverse #SocialDeterminants was associated with #neurobiological abnormalities in #Schizophrenia spectrum conditions, linking SDOHs to clinical outcomes and supporting equity-oriented approaches. ja.ma/4vVGcjW

💬 Editor's Note by Dost Öngür, MD, PhD: In a randomized clinical trial, semaglutide reduced hemoglobin A1c and body weight and improved physical quality of life in patients with #schizophrenia, #prediabetes, and #obesity, w/o negative effects on mental health. ja.ma/4xZHYSH

In a nationwide Finnish cohort, adolescents exposed to peers’ mental disorder diagnoses and genetic predispositions had increased risk for later mental disorders, especially within school-based peer networks. ja.ma/4feupay

GLP-1 receptor agonist use and misuse were common among people with #EatingDisorders, with many reporting adverse events, underscoring the need for pharmacovigilance as availability increases. ja.ma/3Sv5YNi

Use and Misuse of GLP-1 Receptor Agonists Among People With Eating Disorders

This cross-sectional study evaluates the prevalence of glucagon-like peptide-1 (GLP-1) receptor agonist use and misuse among people with eating disorders in the US.

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Systematic Review: Greater exposure to adverse #SocialDeterminants was associated with #neurobiological abnormalities in #Schizophrenia spectrum conditions, linking SDOHs to clinical outcomes and supporting equity-oriented approaches. ja.ma/4vF5V03

The FDA approved gepirone extended release for #Depression based on 2 positive trials despite 11 negative or inconclusive trials, highlighting the agency's use of regulatory flexibility and trial-level statistical significance. ja.ma/3Suv7HU

Assessing Drug Efficacy After Multiple Negative Trials

This Special Communication reviews the US Food and Drug Administration evaluation of 1 investigational drug (gepirone extended release) for major depressive disorder with conflicting evidence of benefit.

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Targeted psychological and psychosocial interventions for #Schizophrenia, including avatar therapy, reduced the severity of #AuditoryHallucinations with small to medium effects and high acceptability. ja.ma/4oPgTNR

Individualized, connectivity-based targeting of accelerated transcranial magnetic stimulation produced significantly greater antidepressant effects than scalp-based targeting in adults with treatment-resistant #Depression. ja.ma/4v5sqKI

💬 Editorial: Connectivity-based targeting for transcranial magnetic stimulation demonstrated greater antidepressant effects and precision than scalp-based approaches in adults with treatment-resistant #Depression. ja.ma/3QHY2rn

A New Era of Precision Neuromodulation in Psychiatry

Over the past century, advances in neuroimaging and cognitive neuroscience reshaped how we understand psychiatric disorders, expanding the portfolio of evidence-based treatments while routine clinical practice has mostly relied on trial and error. Precision medicine has steadily extended to...

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Systematic Review: Greater exposure to adverse #SocialDeterminants was associated with #neurobiological abnormalities in #Schizophrenia spectrum conditions, linking SDOHs to clinical outcomes and supporting equity-oriented approaches. ja.ma/4aFiKyW

Targeted psychological and psychosocial interventions for #Schizophrenia, including avatar therapy, reduced the severity of #AuditoryHallucinations with small to medium effects and high acceptability. ja.ma/4eCkrhP

📝 Narrative Review: Low-dose #Lithium exposure is linked to neuroprotective effects, reduced #Dementia risk, and cognitive stabilization in mild cognitive impairment, supporting further clinical evaluation. ja.ma/4xpBdtk

Evolution of Lithium as a Disease-Modifying Agent in Dementia

This narrative review synthesizes more than 75 years of evidence to evaluate lithium’s evolution from mood stabilizer to candidate neuroprotective intervention.

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Targeted psychological and psychosocial interventions for #Schizophrenia, including avatar therapy, reduced the severity of #AuditoryHallucinations with small to medium effects and high acceptability. ja.ma/4eaNSIU

Disrupted gastrointestinal interoception predicted relapse and symptom severity in weight-restored females with #AnorexiaNervosa, supporting ingestible mechanosensory probes as scalable tools for monitoring and relapse prevention. ja.ma/4a4UDcM