Among older adults, #ADHD was associated with increased risk of later mild cognitive impairment or dementia, and higher genetic liability was also associated with greater risk. ja.ma/4rTD1Io

💬 Viewpoint: For older adults in Africa, voice-first #MentalHealth care may better match routine phone use and literacy realities than app-based or text-based services. ja.ma/477YKmD

💬 Viewpoint: For older adults in Africa, voice-first #MentalHealth care may better match routine phone use and literacy realities than app-based or text-based services. ja.ma/3VVzBZM

Among older adults, #ADHD was associated with increased risk of later mild cognitive impairment or dementia, and higher genetic liability was also associated with greater risk. ja.ma/4hKq3s1

Developmental changes in GRIN2A expression may help explain the timing of psychosis in #Schizophrenia and support stage-specific and genetically informed treatment approaches. ja.ma/4yvYbz6

A context-sensitive road map for #MentalHealth system scale-up indicates that governance, supervision, referral pathways, monitoring, and local adaptation are necessary for sustainable implementation. ja.ma/4hqhhyY

US #MentalHealth and #SubstanceUseDisorder expenditures totaled $174 billion in 2021-2023, or 7.0% of all medical spending, with ambulatory services accounting for the largest share. ja.ma/4hmVBFt

Maternal #PlacentalGrowthFactor trajectories diverged in the third trimester in pregnancies where children were later diagnosed with #ADHD, while endothelin-1 did not differ. ja.ma/4yPn6wW

💬 Viewpoint: In #Psychiatry, care for #Deaf and hard-of-hearing patients requires clinical competency because hearing loss, signed language, and social bluffing can complicate the Mental Status Examination and affect diagnosis. ja.ma/47cOyJh

💬 Viewpoint: A special collection in #Psychiatry highlights early-career investigators studying clinical equity, structural #MRI and machine learning, ultraprocessed foods and depression, and placental growth factor trajectories. ja.ma/4rrJolZ

Structural #MRI with machine learning estimated individual delay discounting in college-aged participants, with white matter volumes showing stronger performance than gray matter volumes. ja.ma/3TMXbXY

In patients with #Depression and high #UltraprocessedFoods intake, a low-ultraprocessed-food diet was feasible and acceptable, and depressive and anxiety symptoms were lower during the intervention period vs a regular diet. ja.ma/4xIUhBI

Interview with Laura Fässler, MSc, author of Psychological Interventions Targeting Auditory Hallucinations in Persons With Psychotic Disorders: A Systematic Review and Meta-Analysis. Hosted by John Torous, MD. ja.ma/4romkoa

Many studies using #Neurodivergent or #Neurodiverse terminology identified participants through self-report or self-identification, and some did not specify any diagnosis. Precise diagnostic descriptors may improve clinical research and practice. ja.ma/471eTKf

📝 Viewpoint: #Cannabis commercialization is a modifiable public health exposure shaped by policies on access, potency, labeling, and marketing. Regulating these features may reduce psychiatric risk beyond legalization status alone. 10.1001/jamapsychiatry.2026.2869

📝 Viewpoint: High-dose #psychedelic #clinicaltrials remain poorly masked, which limits isolation of pharmacological effects from expectancy effects. More aggressive active comparators and reduced disclosure may strengthen causal inference. ja.ma/4gX0swJ

Among women with #BulimiaNervosa, structural #MRI identified lower nucleus accumbens volume and lower temporal cortical surface area vs healthy control individuals, supporting altered reward and social cognition circuits. ja.ma/477nBql

In a Danish cohort, parental similarity for #PsychiatricDisorders was substantial and was associated with higher prevalence and higher family-based heritability than expected under random mating. ja.ma/3TpVqjj

💬 Viewpoint: In #Psychiatry, large language models should be used as clinical instruments, with clinician accountability and source-grounded verification before output influences care. ja.ma/4xeSxQq

💡 Special Communication: In psychiatry, #PolygenicScores, rare variant testing, and #Pharmacogenomics may have value when used selectively to inform diagnosis, prognosis, monitoring, and medication safety rather than population-wide screening. ja.ma/3UD8l1I

Among adults with serious mental illness, #GLP1 receptor agonists vs #SGLT2 inhibitors were associated with lower mortality and fewer major cardiovascular events, with greater absolute benefit in serious mental illness. ja.ma/4r3cmZy

💬 Viewpoint: Family-based care for #Psychosis may need to address the digital home, where #SocialMedia and #ArtificialIntelligence shape symptom interpretation, conflict, treatment beliefs, and relapse warning signs. ja.ma/4A0j7zd

GLP-1 receptor agonist use and misuse were common among people with #EatingDisorders, with many reporting adverse events, underscoring the need for pharmacovigilance as availability increases. ja.ma/3SaIDkj

Use and Misuse of GLP-1 Receptor Agonists Among People With Eating Disorders

This cross-sectional study evaluates the prevalence of glucagon-like peptide-1 (GLP-1) receptor agonist use and misuse among people with eating disorders in the US.

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The FDA approved gepirone extended release for #Depression based on 2 positive trials despite 11 negative or inconclusive trials, highlighting the agency's use of regulatory flexibility and trial-level statistical significance. ja.ma/4g6sYM8

Assessing Drug Efficacy After Multiple Negative Trials

This Special Communication reviews the US Food and Drug Administration evaluation of 1 investigational drug (gepirone extended release) for major depressive disorder with conflicting evidence of benefit.

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Systemic interleukin-6 inhibition demonstrated treatment-sensitive outcomes and clinically meaningful effect sizes in patients with difficult-to-treat #Depression and low-grade #Inflammation. ja.ma/4qkzTVg

Interleukin 6 as a Treatment Target for Depression

This proof-of-concept randomized clinical trial identifies likely treatment-sensitive outcomes and effect size for systemic interleukin 6 inhibition in patients with difficult-to-treat depression

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Exposure to #ChildhoodTrauma was linked to #BipolarDisorder in part via reduced volume of the hippocampus and thinner cortex in the medial orbitofrontal and superior frontal gyrus. ja.ma/4zpGgKW

Brain Morphology Mediators of the Association of Childhood Trauma With Bipolar Disorder

This case-control study analyzes the mediating effects of brain morphology on the association of childhood trauma with bipolar disorder.

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In individuals at clinical high risk for #psychosis, reduced temporal stability of EEG microstates was associated with earlier conversion and increased positive symptom severity. ja.ma/4gitPrI

EEG Microstate Instability and Clinical Outcomes in High Risk of Psychosis

This case-control study evaluates the association between electroencephalography microstates and risk of psychosis and other clinical outcomes.

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In a cohort study, #PolygenicScores identified more patients at risk for #ADHD, #Depression, and #Schizophrenia than recurrent copy number variants, while both methods were complementary for risk assessment in #Autism. ja.ma/4gBALkZ

Variants and Psychiatric Outcomes in the Context of Polygenic Scores

This genetic association study evaluates the association of recurrent copy number variants and polygenic scores with genetic risk factors for psychiatric disorders in the population.

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Family genetic risk scores across 18 psychiatric disorders indicated six correlated factors: psychotic, externalizing, anxiety, neurodevelopmental, mood, and eating disorders. ja.ma/4zpGgdU

Structure of the Genetic Risks for Psychiatric Disorders

This cohort study evaluates the structure of genetic risk factors associated with 18 diverse psychiatric and substance use disorders.

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Individualized, connectivity-based targeting of accelerated transcranial magnetic stimulation produced significantly greater antidepressant effects than scalp-based targeting in adults with treatment-resistant #Depression. ja.ma/4hzMkdA

Connectivity- vs Scalp-Based Targeting of Accelerated TMS for Depression

This randomized clinical trial estimates the effect size of connectivity- vs scalp-based targeting of accelerated transcranial magnetic stimulation for treatment-resistant depression.

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