www.nature.com/articles/s41... A milestone article, the result of a long going project (started in 2018). The more or less exhaustive collection of DNA binding motifs for TFs was built, a lot of new ideas on recruitment of new transcription factors were formulated.

An expanded codebook of human transcription factor DNA-binding specificity - Nature

Results from a panel of assays that analyse different aspects of DNA sequence specificity reveal more than 100 new motifs to aid the characterization of putative human transcription factors.

nature.com

(1/4) In IBIS (ibis.autosome.org), we challenged teams from all over the world to decipher the DNA recognition code of human transcription factors. Today, we are excited to announce the Final IBIS Conference scheduled for November 27, 2024.

(2/12) The human genome encodes ~1.5 thousand transcription factors (TFs), and hundreds of them still lack "DNA motifs", i.e., compact human- and machine-readable representations of the TF-DNA binding specificity.

(3/12) There are a multitude of high-throughput methods for assessing the DNA binding specificity of transcription factors. The variety of existing motif discovery tools is even greater. Which one to use?

(1/12) Excited to present the results of the large-scale benchmarking of DNA motif discovery tools using the Codebook data compendium on poorly studied human transcription factors and the Codebook Motif Explorer: dx.doi.org/10.1101/2024..., mex.autosome.org ⬇️.