Earl K. Miller

@earlkmiller.bsky.social

Picower Professor of Neuroscience @ MIT Cognitive neuroscience, executive brain functions, consciousness, and bass guitar. You know, the good stuff. ekmillerlab.mit.edu Co-founder, Neuroblox https://www.neuroblox.ai/

Follow this link to hear me talk about brain waves, consciousness, and AI live on Canadian AM radio. BIANCA’S BIZARRE: What If Your Brain Thinks In Waves? 9/2/26 The Early Edition on AM1150/CKFR in Kelowna, British Columbia. www.am1150.ca/show/the-ear...

The Early Edition : AM 1150

Gary Barnes interviews local, national and international guests skewed towards locally-based issues. He also presents news, and information on the buzz topics of the day through interviews and guests.

am1150.ca

Your breathing and your brainwaves match shape, breath by breath. Cycle-by-cycle respiration waveforms are coupled with the shape of neural oscillations www.jneurosci.org/content/earl... #neuroscience

Cycle-by-cycle respiration waveforms are coupled with the shape of neural oscillations

Beyond sustaining life, breathing is a vital physiological rhythm that shapes cognition, perception, emotional regulation, and mental health. Breathing has a direct effect on neuronal excitability and is coupled to neural oscillations across a variety of brain regions. Notably, both respiration and neural oscillations are asymmetric and not perfectly rhythmic: for example, every breath has a different shape and duration, and is interspersed with variable pauses. Here, we examined the coupling between breathing and the brain by quantifying the nonsinusoidal features of each breath and comparing it to the shape of each corresponding neural oscillation cycle. By leveraging invasive human brain recordings from 16 participants (8 female, 8 male), we found respiration-neural waveform coupling on a breath-by-breath, cycle-by-cycle basis across limbic and cortical forebrain regions. For decades, the dominant perspective on cognition and mental health have focused on the brain, but recent work is highlighting the importance of brain-body interactions. Our results show that the coupling between breathing and neural activity is much richer than previously appreciated, and our approach opens new avenues for studying these peripheral-to-central nervous system interactions in a more robust, temporally precise manner. Significance Statement Breathing shapes brain activity, but prior work has characterized this coupling by aggregating across many breath cycles, leaving the fine-grained shape of individual breaths unexamined. Here, we show that the precise waveform shape of each breath is coupled to the shape of corresponding neural oscillation cycles in the human forebrain, on a breath-by-breath basis. Using invasive brain recordings from 16 epilepsy patients, we demonstrate that temporal and amplitude features of individual breaths are linked to the morphology of neural oscillations in limbic and cortical regions. This cycle-by-cycle respiratory-neural coupling reveals a richer and more temporally precise relationship between breathing and brain activity than previously appreciated.

jneurosci.org

The cortex and cerebellum split the labor: the cortex provides a stable, general-purpose movement blueprint, while the cerebellum reorients that same blueprint differently for each context Granule cells reorient cortical trajectories to separate contexts www.nature.com/articles/s41... #neuroscience

Granule cells reorient cortical trajectories to separate contexts - Nature

Simultaneous imaging of premotor cortex and cerebellar granule cells in mice learning two skills in parallel shows that trajectories generalize in cortex but coherently reorient apart in granule cells...

nature.com