Recent study pushes the boundaries of resolving the dynamic mechanisms of GPCR-G protein recognition Read the paper: www.nature.com/articles/s41... Request a quote: www.quantifoil.com/request-quote #cryoEM
Quantifoil
@quantifoil.bsky.social
We focus on the small stuff so you can too: enabling the resolution revolution with high quality support films for cryo-electron microscopy. Part of @SPTLabtech.bsky.social
HexAuFoil yielded the highest resolution structure (1.25A) of rubisco to date! This Rubisco structure is not only cool but holds promise for a greener future for all of us! Check out the paper: eu1.hubs.ly/H0vrl_H0 Request a quote: www.quantifoil.com/request-quote #HexAuFoil #cryoEM
View our new grid selection guide here: www.quantifoil.com/grid-selecti... Find the perfect support for your project and reach out to us here for a quote: www.quantifoil.com/request-quote #CryoEM #StructuralBiology #SingleParticleAnalysis #electronmicroscopy #CLEM #DrugDiscovery #InSituTEM
Tereza shares how switching to HexAuFoil grids gave her a 1Å resolution boost on a sub-100kDa membrane protein - while collecting less data and using fewer particles. Learn how these grids simplify prep, improve reproducibility, and optimize Titan Krios setups. www.youtube.com/watch?utm_co...
We're excited to be back live and in person at ACA 2025 in Lombard IL with @sptlabtech.bsky.social - drop by booth 23 and get the latest news on #cryoEM sample prep with chameleon and HexAuFoil. #ACA2025 @acastructuralsci.bsky.social
Quantifoil and @sptlabtech.bsky.social Labtech are excited to be once again attending the CCP-EM Spring Symposium in Nottingham from 23-25th April 2025. We hope to see some of you there - but don't forget you can attend virtually if you can't make it in person!
and the Core Facility for Integrated Microscopy – CFIM – funded by @novo-nordisk.bsky.social where we collected our cryo-EM data on the first batch of newly developed HexAuFoil grids from @quantifoil.bsky.social
We spoke with Rectify about the first commercial use of HexAuFoil®, to gain new insights into the bile regulator BSEP. Our grids improved resolution by almost 0.5 Å, helping eliminate toxic therapeutic candidates. www.quantifoil.com/products/hex... #drugdiscovery #cryoEM
HexAuFoil Quote
Order your pre-production batch of the revolutionary, new HexAuFoil ultra-small hole gold cryoEM grids today.
quantifoil.com
Catch them while you can! Available to ship now: HexAuFoil ultrasmall holey gold #cryoem specimen supports for better images every time. “If I need small molecule bound structures […] the HexAuFoils will be my go-to grids.” Imre Gonda - University of Zurich
With a revolutionary small-hole, all-gold design, HexAuFoil® grids deliver virtually movement-free imaging and exceptional uniformity in ice thickness. Watch our quick video demo: t.co/rD3OdXPL6o #cryoEM #structuralbiology #microscopy
eBIC Loading your samples on HexAuFoil grids
YouTube video by Quantifoil
youtu.be
6) We were able to achieve these structures using our newly developed (an)aerobic freezing protocol using the SPT chameleon. This allowed us to generate high quality girds with thin ice without having to be in an anaerobic chamber! www.biorxiv.org/content/10.1...
Final conference of the year and what a pleasure to spend it MRC LMB with BCA BSG Winter Meeting. Lovely day discussing #cryoem and #crystallography, and congratulations to Peter Harrison from eBIC for taking away the final grid race prize, with a fab 16 sec time!
This work is just our latest saga of tackling the complexities of the small heat shock proteins, following on our recent work with the human aB-crystallin that was just published: www.nature.com/articles/s41...
Dynamic fibrillar assembly of αB-crystallin induced by perturbation of the conserved NT-IXI motif resolved by cryo-EM - Nature Communications
Here the authors show that mutating αB-crystallin’s NT-IXI motif transforms polydispersed oligomers into ordered fibrils, enabling cryo-EM to provide insights into the principles of high-order assembl...
nature.com
Thrilled to share our recent discovery from the Agrawal and Ojha Labs: an Actinobacteria-specific ribosome hibernation factor bound to Mycobacterium tuberculosis ribosomes isolated from biofilms. www.biorxiv.org/content/10.1... @cryoempapers.bsky.social @mycobacterium.bsky.social
Hello, Bluesky! To kick things off here, we’re excited to share: The SLFN11 story continues! We combined cryo-EM and biochemical assays to explain how phosphorylation regulates SLFN11´s tRNA cleavage and ssDNA binding activities. Check out our new paper here www.nature.com/articles/s41... + movie
Oh my. This is just gorgeous from Misha Kudryashev's lab (I don't think he's here yet?). Love to see it. V ATPase resolved directly in synaptic vesicles 🤤 Lots of other neat observations in there also. Congrats to all involved! www.pnas.org/doi/10.1073/...
I’m guessing there has been a big influx of synchrotron and cryoem embedded synch people - shout out if you want to be added to this starter pack!
Martin Walsh@walshdls.bsky.social · 2y agook to all synchrotron and cryoEM people out there ...a hastily put together starter pack! go.bsky.app/UThze5z
The grid-racing at GDR_Appicom 5th Plenary meeting was epic! In this beautiful location, we had a lot of very talented and very competitive #cryoem scientists competing for the prize. Including Irene Dossou of I2BCParisSaclay pictured here!
A peaceful sunset at Carry-le-Rouet on the last night of the wonderful 5th APPICOM plenary meeting, but keep your 👀 peeled tomorrow for a thread because the peace is hiding absolute scenes at the #cryoem grid racing!
Excited to share our new study with the Müller and @SchullerJm labs, online @nature: https://www.nature.com/articles/s41586-022-04971-z This is T. kivui, an anaerobic bacterium. It uses hydrogen energy to store #CO2. How does it do it? #CryoET revealed membrane-anchored bundles of...
👇 Did you know one can use pulsed lasers not only to increase contrast in #cryoEM images, but also to reduce preferred particle orientation, by melting & re-vitrifying samples in a controlled way? ❄️🔬
cryoEM papers@cryoempapers.bsky.social · 2y agoLaser Flash Melting Cryo-EM Samples to Overcome Preferred Orientation biorxiv.org/cgi/content/short/2024.11.21.624652v1
Looking forward hearing the latest membrane protein updates from the APPICOM 5th plenary meeting next week with @sptlabtech.bsky.social - and delighted to provide an update on HexAuFoil #cryoem grids!
Great to see our work on the #cryoem structure of the human TSC:WIPI3 lysosomal recruitment complex! Awesome effort from co-authors @charlesbj.bsky.social and Laura D'Andrea with @drellisdon.bsky.social doing the heavy lifting leading the project. www.science.org/doi/10.1126/...
Structure of the human TSC:WIPI3 lysosomal recruitment complex
The complete TSC structure reveals how lysosomal targeting proteins and phosphoinositides coordinate mTORC1 inhibition.
science.org
5 days left to apply for the postdoc and research scientist positions in cryo-EM & protein design in our lab! 🔬🦠🧬 They're fully funded for 4 years. Salary: 42,800 euros gross per year. See details below:
Roger Castells@rcastellsg.bsky.social · 2y agoWe're currently looking for new members to join our lab! If you're excited about this research, feel free to reach out! We already have two open, fully funded positions: 🔬- Postdoc: cnio.es/en/empleo/po... 🧪- Senior Scientist: www.cnio.es/en/empleo/re...
Fantastic a couple of weeks ago to speak with Bharat Reddy of Rectify Pharma - his recent pre-print on BSEP is the first pre-print that uses commercially produced HexAuFoil #cryoem grids! 😍😎Listen to the whole interview: eu1.hubs.ly/H0dTfFZ0 #drugdiscovery
HexAuFoil Quote
Order your pre-production batch of the revolutionary, new HexAuFoil ultra-small hole gold cryoEM grids today.
eu1.hubs.ly
I am about to be recruiting two post-docs to work on cryoEM and cryoET of amyloid aggregates... Anyone interested please drop me a line while the wheels of our HR department turn.............
A post-doc position available to work in Raffaele Ieva and our group. See image attached for more details.
📄NEW PUBLICATION: A disease resistance protein triggers oligomerization of its NLR helper into a hexameric resistosome to mediate innate immunity (2024) @amiralito.bsky.social @adnroide.bsky.social @kamounlab.bsky.social @mauriciocontreras @JMadhuprakash www.science.org/doi/10.1126/...
A disease resistance protein triggers oligomerization of its NLR helper into a hexameric resistosome to mediate innate immunity
Cryo-EM analysis revealed the homohexameric resistosome structure of NbNRC2 activated with Rx and Potato virus X coat protein.
science.org