I have lots of opinions—but for your sake, I’ve limited them to segmentation in cryo-ET for this article 😉 www.sciencedirect.com/science/arti... #teamtomo

Segmenting cryo-electron tomography data: Extracting models from cellular landscapes

Cryo-electron tomography provides an unprecedented view of cellular architecture, yet extracting meaningful biological insights remains challenging. S…

sciencedirect.com

🚨New preprint!🚨 #teamtomo We expanded Surface Morphometrics to quantify membrane thickness from cryo-ET—revealing local variation across organelles. Led by the lab’s first grad student, @mmedina300kv.bsky.social (defending Monday! 🍾) w/ @attychang.bsky.social @hamid13r.bsky.social & @tomo.science

bioRxivpreprint@biorxivpreprint.bsky.social · last yr.

Surface morphometrics reveals local membrane thickness variation in organellar subcompartments https://www.biorxiv.org/content/10.1101/2025.04.30.651574v1

A Perspective by @stephanieaw.bsky.social and @fraserlab.com discusses ways macromolecules use conformational entropy to control binding, catalysis, and allostery www.nature.com/articles/s41...

Advances in uncovering the mechanisms of macromolecular conformational entropy - Nature Chemical Biology

Protein conformational entropy plays a vital role in functions like binding and catalysis. This Perspective discusses three ways macromolecules use conformational entropy: prepaying entropic costs, re...

nature.com

Arzeda has been awarded DARPA funding to advance AI-driven protein design—even with limited data! We're pushing the boundaries to create next-gen proteins for national security, sustainability, and beyond. #AI #ProteinDesign www.prnewswire.com/news-release...

Arzeda Awarded DARPA Funding to Advance AI-Driven Protein Design for National Security

/PRNewswire/ -- Arzeda, the industry-leading Protein Design Company™, today announced it has been selected for an award from the Defense Advanced Research...

prnewswire.com

Tomorrow(!) morning at 9AM pacific, I am giving a webinar for EMS discussing the surface morphometrics pipeline and our approach to contextual structural biology #teamtomo. Free to attend, hope to see you all there! us06web.zoom.us/webinar/regi...

The human mitochondrial ClpXP is uniquely assembled and regulated compared to its bacterial counterparts. Congrats to Kelly Chen on her years of hard work on this challenging complex! www.biorxiv.org/content/10.1...

Come be my colleague! UW Tacoma is hiring an Assistant Professor of Biochemistry. We're looking for someone excited about mentoring undergraduates in research, inclusive teaching, and being part of an interdisciplinary community of scholars. apply.interfolio.com/154390

The Barad lab is hiring across all levels. Open positions here: baradlab.com/join/. If you are interested in doing cutting edge tomography and computational methods development to study intracellular bacterial infection, and living in Portland, OR, but don't fit the openings, reach out anyway!

I'm happy to share the publication of my postdoctoral work from the Lander lab at Scripps. We solved previously-unobserved conformations of human TTR, an 55kDa amyloid-forming protein, to great resolution. www.biorxiv.org/content/10.1...

The conformational landscape of human transthyretin revealed by cryo-EM

bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

biorxiv.org

baradlab.com (aka tomo.science ) is now online! Beginning to feel like a real lab!

The Barad lab is open!

Unusual repetitive DNA sequence in the E. coli genome --> CRISPR ---> genome editing Ψ Pseudouridine ---> mRNA immunogenicity and potency ---> mRNA COVID vaccine #basicresearch Dear funders, dear governments please increase the basic research budget !