🩺 #Yeast as a disease model: a screen in cardiolipin-deficient yeast identified ebselen as a mitochondrial rescue compound effective across seven fungal models of mitochondrial disease, patient fibroblasts, cardiomyocytes and mice 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

📊 Different methods for profiling #Yeast cell walls capture different things. Scatter-based flow cytometry tracks mannan abundance; lectin fluorescence reflects surface composition. Approaches are complementary rather than interchangeable 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

Catching up on a #yeast gene? Start with the Literature section on #SGD gene pages. New: a chart of curated papers by year, plus the latest publications. The full curated set of papers, organized by relevance, is only one click away. #UIupdate www.yeastgenome.org/blog/new-lit...

🖖 What drives replicative aging in #Yeast? An @oregonstate.edu 🦫 screen found 132 variant genes & 60 differentially expressed genes with little overlap, suggesting longevity is governed by many genes through diverse mechanisms 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

✂️ A nonessential #Yeast spliceosome factor w/conserved domain touching the catalytic core turns out to matter more than expected: Cwc15 stabilizes active site & facilitates structural transitions, implications for splice site proofreading 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

The first integrated #eukaryotic #genome #database has now been running for 30+ years. 🧬 A new history of #SGD traces how a #Stanford #yeast database became a global hub for #genetics, functional #genomics & #humanDisease research. 📄 bit.ly/SGD30FEMSYeast #bioinformatics

🧘 #Yeast RPL22 pre-mRNA acts as its own regulator. The intron toggles between 2 competing structures: one blocks splicing, one permits it. Rising Rpl22 levels shift the balance toward inhibition, creating a protein-responsive RNA switch 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

♻️ #Yeast Acs2 generates acetyl-CoA locally at chromatin, while its mammalian ortholog ACSS2 also recaptures acetate from histone deacetylation at promoters. This acetate recycling loop couples metabolism ↔️ chromatin state across species 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

New on SGD gene pages: #EC numbers for enzymes, #AlphaFold structure thumbnails for all in the Protein section! Click through to Protein Details for interactive AlphaFold viewer, domains, modification sites, more! #yeast HOG1: www.yeastgenome.org/locus/hog1#p... www.yeastgenome.org/blog/enzyme-...

New on SGD gene pages: #Regulation summary graphic! See how many putative Regulators and Targets a gene has, based on experimental evidence. Click for all regulation annotations and a regulator/target diagram. Try #HOG1: www.yeastgenome.org/locus/S00000... #yeast www.yeastgenome.org/blog/new-reg...

🏋️ Not all #Yeast strains handle acetic acid equally. Respiratory capacity and carbon flux determine survival under acid stress, and two S. cerevisiae strains show strikingly different responses with implications for strain engineering 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

🧲 How does #Yeast CAF-1 find the replication fork to deposit histones? Via PCNA, using not 1 but 2 PIP motifs. The newly found PIP1β makes atypical extended contacts w/second PCNA subunit; disrupting both motifs abolishes CAF-1 function 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

🗑️ #Yeast nuclear ubiquitin ligase Uls2 has surprising side job: tagging cytosolic proteins for degradation. Orphaned/ oxidatively damaged proteins aggregate in nucleus & become SUMO-dependent substrate ➡️ = compartment-spanning QC pathway 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

🫧 Autophagosome membranes don't just grow by lipid transfer. #Yeast cryo-ET shows vesicles clustering around and fusing with the phagophore rim during expansion, a contribution that was previously attributed only to the nucleation stage 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

⛓️‍💥 In #Yeast a broken helicase can be worse than no helicase. Inactive Hrq1 binds DNA but can't unwind it= 🙅 inter-strand crosslink repair. ➡️ Sheds light on how partial LoF mutations in human RECQL4 may similarly disrupt genome stability. 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

✂️ The spliceosome has to shed Dib1 before it can start cutting RNA. New #Yeast research shows Dib1's C-terminal tail is what keeps it docked near the catalytic core via Prp8 and Prp31, and losing that tail is enough to kill the cell. 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

🍷🧬 Save the date! #ICYGMB2027 the 33rd Int'l Conference on Yeast Genetics & Molecular Biology comes to Porto, Portugal, July 19-22, 2027! A stellar international lineup of speakers + 16 workshops across yeast biology. Full details 👉 www.i3s.up.pt/ICYGMB2027 #YeastGenetics

🛟 When DNA breaks in #Yeast, Tel1 phosphorylates Rad9, driving its self-assembly to hold broken ends together & steer repair toward homologous recombination. A Tel1 FAT-domain variant reveals this axis by rescuing end-tethering defects 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

📈 #Yeast Dhh1 (human DDX6) bridges deadenylation and decapping in mRNA decay, but how it's activated was unclear. Edc3 and Not1 tune its ATPase activity through distinct mechanisms, cooperating for a 200-fold boost 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

🕳️ #Yeast CCP isn't just an H₂O₂ scavenger, it's a sensor. When H₂O₂ spikes in respiring mitochondria, hole hopping oxidizes H175, releasing the heme to activate catalase A and keep the ETC running efficiently. Also, oxene≠ox...or does it? 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

🔬 Single #Yeast cells trapped in alginate microspheres ➡️ every division is traceable. Confocal microscopy + a mathematical formula reconstructs the full replicative history of a founder cell, revealing age of every cell in the microcolony 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

🔄 A single amino acid change in histone H2A causes transcription chaperone yFACT to pile up at the wrong end of genes. H2A's docking domain is essential for yFACT to release properly after transcription @micropub7n.bsky.social 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

🥝🍷 Spontaneous fermentation makes complex wines but risks spoilage. High #Yeast inoculum in semi-spontaneous kiwifruit fermentation cuts acetic acid while retaining indigenous microbiota that boost fruity esters and floral terpenoids 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

⚗️ Getting proteins out of #Yeast efficiently isn't just a downstream problem. Cultivation pH, growth phase, culture mode & glucose availability all reshape the cell wall, directly affecting how much protein mild disruption can recover 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

A plug-n-play platform for evolving yeast rDNA identifies variants that improve noncanonical amino acid incorporation across tRNA synthetase/tRNA pairs, establishing ribosome engineering as a route to eukaryotic genetic code expansion 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

🔬 How does #Yeast build a kinetochore on DNA that resists nucleosome formation? Cryo-EM reveals 4 complexes, 2 never seen before. Ndc10 trimerization stabilizes the inner kinetochore. Without it, assembly & chromosome segregation fail 🧬 #YeastResearch 🧪 #SGD 🔬 yeastgenome.org/reference/S1...

🛠️ Bacteria have long had plasmids w/tunable copy numbers. Eukaryotes haven't, until now: new #Yeast platform =stable, programmable gene dosage control across a 109-copy range. Applications from #MetabolicEngineering ➡️ strain preservation 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

⚗️ L-tartaric acid is essential for food and pharmaceuticals but typically extracted from grapes. #Yeast can now make it from scratch via a de novo pathway combining computational enzyme mining, cofactor engineering, & protein design 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

🌳 @bloomingtonindiana.bsky.social grad students isolated wild #Yeast from a 230-year-old campus oak & partnered with local breweries to produce a fruity-funky ale for the US 250th anniversary🍻 🔥 Place-based, community-embedded CUREs 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

🧠 #Yeast cells remember where they divided. Bud neck septin double ring acts as a selective spatial memory, concentrating proteins that mark cytokinetic remnants & preserving molecular record of division to subsequent cell generations 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...