🧪 New at SGD: Redesigned chemical pages! ✨ Interactive 2D structures at top 📊 Phenotype & GO annotations on one page 🔗 Links to ChEBI, PubChem, Rhea 🔬 Shared Chemicals network for related compounds Example (cisplatin): www.yeastgenome.org/chemical/CHE... Browse: www.yeastgenome.org/search?categ...

😰 When the going gets tough: Review shows #yeast don't just survive stress; they strategically switch to sexual reproduction & sporulation. Multiple sensing pathways coordinate this shift from growth ➡︎ reproduction under harsh conditions 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

☕ Caffeine sensitivity reveals function: #Yeast ILM1 deletion causes caffeine hypersensitivity & G1 cell cycle delays- uncharacterized gene linked to TORC1 signaling pathway that controls cell growth & division 🧬 #YeastResearch 🧪 #SGD 🔬 @micropub7n.bsky.social www.yeastgenome.org/reference/S1...

🎉 SGD's protein complex pages just got a major upgrade! ✨ GO annotations now on main page (no more tab-switching!) 🧬 New Composition section with stoichiometry & PDB links 🔗 Shared Biology networks show related complexes Check it out: www.yeastgenome.org/complex/CPX-...

🔬 New at SGD: Functional Networks section on gene & complex pages! ✨ Shared Annotations networks show related genes 🧬 GO-CAM pathway models reveal causal relationships 📊 470 genes now have GO-CAM models Explore: www.yeastgenome.org/locus/MET2#f...

🔍 Check out SGD's redesigned search landing page! Improved autocomplete, quick category browsing, and highlights of newly added literature & recent annotations. 🔴 Click the big red "Explore SGD" button on the SGD homepage or just hit return in an empty search box 👉 www.yeastgenome.org/search

🌙 Moonlighting protein review: #Yeast Hxk2p doesn't just process glucose - it's a metabolic hub controlling gene expression, energy homeostasis & cellular physiology. Loss triggers system-wide shift toward respiratory metabolism 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

☣️ Toxin engineering advance: #Yeast killer toxin K2 analyzed through systematic alanine scanning, showing enhanced toxicity variants & altered target specificity through single mutations, providing platform for protein engineering 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

🗺️ Mapping RNA modifications: #Yeast study uses Nanopore sequencing and adapted D-seq method to map base modifications across mitochondrial tRNAs. Identifies Dus1 and Smm1 enzymes responsible for specific dihydrouridine sites 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

🎮 Mitochondrial fine-tuning: #Yeast phospholipase Fmp30p controls PI lipid levels ➡️ regulates CoQ production. When PI accumulates, CoQ biosynthesis increases with enzyme expression, showing how membrane lipids control energy metabolism 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

💌 Molecular matchmaking for DNA repair: #Yeast Rad55-Rad57-SHU complex selectively delivers Rad51 to damaged DNA sites. Cryo-EM snapshots show how this conserved tumor suppressor pathway works across species 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

🧰 Genome editing upgrade! Multiplex CRISPR platform: ✅ enables simultaneous editing of multiple #Yeast genes 🚫 no complex vectors ‼️One editing round modified 9 targets and boosted target production >9fold ➡️ #biomanufacturing applications 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

💪 Vesicle protection revealed: #Yeast Atg23 protein is protective escort for Atg9 vesicles during autophagy, preventing premature fusion on way to autophagosome formation sites- phosphorylation switch releases escort on arrival 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

🗑️ Protein quality control enhancer: #Yeast Ufd2 (E4 enzyme) adds extra ubiquitin tags to ensure problematic proteins get degraded. Extension system is essential for handling protein stress, maintaining cell health 🧬 #YeastResearch 🧪 #SGD 🔬 @micropub7n.bsky.social www.yeastgenome.org/reference/S1...

🤝 Molecular helper discovered: #Yeast Pbr1 protein's long-mysterious function revealed as Fks1 folding assistant in the ER. Without this helper, cell wall synthesis fails and cells become unstable- teamwork at the molecular level 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

🎯 Genome repair targeting: #Yeast Smc5/6 complex preferentially binds single-strand DNA gaps and junctions using its head-NSE module. High-resolution imaging shows "bead-on-stick" structure that homes in on DNA damage sites for repair 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

👉Species-specific enzyme evolution: Human MINDY3's EF-hand domain serves dual purpose, binding long ubiquitin chains AND recruiting DNA repair factors. Comparison to #Yeast homolog Miy2 reveals different cleavage patterns across species 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

🧠 Repurposed hypertension drug has potential against #Alzheimer's: Terazosin increases cellular energy production. #Yeast SNF1 mutants provide key testing ground- low ATP cells reveal how enhancing glycolysis reduces protein aggregation 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

🏷️ Sugar tag recognition system: #Yeast adds O-mannose tags to misfolded ER proteins as "destroy me" signals. Study suggests Emp46 & Emp47 lectins read these tags and escort tagged proteins to ERAD degradation machinery for elimination 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

📡 Powerhouse ↔️ Command center: Mitochondria coordinate stress responses by integrating signals between organelles via physical contacts & retrograde pathways, revealing roles beyond energy production! Mechanism conserved #Yeast ➡️ human 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

🌱 Plant waste to biofuel breakthrough: #Yeast naturally can't efficiently transport C5 sugars from plant biomass. Advanced protein engineering creates specialized transporters for sustainable bio-based industrial production 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

🥳🎉 Yippee for stress resistance: #Yeast Yippee-like protein Moh1 creates cellular trade-offs. Increased resistance to H2O2 & acetic acid but greater sensitivity to sodium azide & sulfuric acid, linking metabolism to selective protection 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

🔍 Hidden interaction hub: #Yeast SIR complex transitions from dynamic spreading ➡️ stable chromatin compaction. Sir2 deacetylase connects to Sir4 scaffold through coiled-coil domain, controlling gene silencing switch 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

Join the Pacific Northwest Yeast Club for the 2026 PNWYC annual meeting! July 31st, 2026 at Western Washington University, Bellingham, WA. Registration's FREE. Anyone working in any type of fungal system is welcome! www.pnwyc.net/home

🤼 Chromatin wrestling match: #Yeast Swi-Snf (gene activator) & Tup1-Cyc8 (repressor) battle for control at gene promoters. Both complexes are present simultaneously, with their wrestling match determining whether genes turn on or off 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

🚉 Cellular train station: #Yeast nucleus-vacuole junction acts as bustling hub connecting ER and vacuole for lipid metabolism, storage, & transfer; interface adapts its structure & protein residents based on metabolic needs 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

🍷Hidden yeast compounds revealed: Profiling 48 wine #Yeast strains revealed previously uncharacterized bioactive lipids (LNAPEs) & major strain differences in beneficial omega-3 & -6 fatty acids; could optimize fermentation & wine quality 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

☄️ Tiny protein, big discovery: Tyc1 (Tiny #Yeast Comet 1) forms braided, comet-tail shaped polymers that wrap around microtubules and prevent their destruction by ice-cold CaCl₂ stress. Cross-species insights into cytoskeleton protection 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

🏰 rDNA guardian revealed: #Yeast Paf1 elongation factor prevents transcriptional arrest & maintains rDNA stability. Without Paf1, R-loops accumulate, DNA breaks, and copy number chaos ensues ➡️ transcription quality 🤝 genome integrity 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

💪 Cellular pressure valve: #Yeast uses Csf1 lipid transfer protein to remodel membranes when physical stress threatens bilayer integrity. High pressure reveals hidden lipid remodeling network that maintains flexibility at ER-PM sites 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...