🧪 Lab's latest!! Work by PD (and now PI) Alison Philbrook. C. elegans sensory neurons have gorgeous #cilia. We’ve always thought that a) no cilia = no sensory responses, & b) no IFT = no cilia. Punchline is we thought wrong. Read paper for more! #neuroscience journals.plos.org/plosbiology/...

Cilia structure and intraflagellar transport differentially regulate sensory response dynamics within and between C. elegans chemosensory neurons

The relative contributions of intraflagellar transport (IFT) and cilia structure to sensory neuron responses remains unclear. This study reveals unexpected complexity in the contribution of IFT and ci...

journals.plos.org

Victor and Gary are just the smartest, nicest and most curiosity-driven scientists I know. This also highlights the importance of studying diverse organisms, and emphasizes how shortsighted it is to dismiss a finding because it has no 'relevance to human health'. www.nobelprize.org/prizes/medic...

The Nobel Prize in Physiology or Medicine 2024

The Nobel Prize in Physiology or Medicine 2024 was awarded jointly to Victor Ambros and Gary Ruvkun "for the discovery of microRNA and its role in post-transcriptional gene regulation"

nobelprize.org

Worm picks made, and crosses started. Seems like a good time to announce the Harris lab at Georgia State University!

Unsure how to do threads here yet but here's our latest preprint from GS Tyler Hill 🎉. He describes multiple feedforward and feedback mechanisms involving cGMP and Ca2+ that drive response adaptation on a timescale of mins in a single thermosensory neuron pair. 🧠🟦 🧪 www.biorxiv.org/content/10.1...

Feedforward and feedback mechanisms cooperatively regulate rapid experience-dependent response adapt...

bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

biorxiv.org