If you want to know what 3′UTRs with long conserved sequence stretches do, check out our BioRxiv preprint doi.org/10.64898/202.... They form functional intermolecular 3′UTR-3′UTR interactions that enable co-folding of proteins to rapidly induce transcriptional programs.

IFIT3 Associates with m⁶A-Modified RNA to Restrict Hepatitis C Virus Infection https://www.biorxiv.org/content/10.64898/2026.03.25.714224v1

Check out our new publication, a collaboration with Giovanni Luchetti and Vishva Dixit @ Genentech. We show that the E.coli effector NleL inhibits intestinal epithelial cell extrusion after #inflammasome activation via degrading the kinases ROCK1 and 2!! www.nature.com/articles/s41... Explainer 1/8

Enteropathogenic bacteria evade ROCK-driven epithelial cell extrusion - Nature

The bacterial ubiquitin ligase NleL evades host defence mechanisms both by inhibiting pyroptosis and by preventing infected intestinal epithelial cells from being extruded into the lumen and expelled ...

nature.com

Wonderful opportunity. Go join Emmanuelle’s lab!

Emmanuelle Genoyer@immunuelle.bsky.social · 11mo ago

Excitingly, we are now hiring at all levels!! Please reach out if you are interested in RNA viruses, viral replication, innate immunity, RNA imaging, or are just excited about having fun doing cool science! Information about specific positions here www.genoyerlab.com/join

I'm thrilled to announce I'll be joining the Department of Molecular Genetics & Microbiology at the University of Florida in January 2026! My lab will study RNA virus-host interactions with a particular focus on the spatial regulation of viral replication and innate immune activation. genoyerlab.com

Last Saturday morning ☕ saved for this gem: www.science.org/doi/10.1126/... CRISPR screening reveals TRIM25 as a pH-sensitive sensor that specifically targets foreign RNAs entering through endosomes. N1-methylpseudouridine helps repel TRIM25 binding & enhances protein production.

Exogenous RNA surveillance by proton-sensing TRIM25

Exogenous messenger RNAs (mRNAs) require cellular machinery for delivery and translation but also encounter inhibitory factors. To investigate their regulation, we performed genome-wide CRISPR screens...

science.org

Congrats to Julian and others from @ramlabuw.bsky.social on this cool work that finds that the loss of the RNA-binding protein CELF2 leads to accumulation of endogenous RIG-I ligands! #RNA #innateimmunity #IFNs

Ram Savan@ramlabuw.bsky.social · last yr.

CELF2 suppresses immunostimulatory endogenous RNAs that activate the RIG-I-MAVS pathway in macrophages, preventing type I IFN-signature. Congrats to Julian Smith, Olivia Kern, and all the co-authors for their hard work! #innateimmunity #dsRNA #IFN www.biorxiv.org/content/10.1...

Really cool work from @thehornerlab.bsky.social and colleagues highlighting a role for the UFMylation post-translational modification system in flavivirus viral particle production!

bioRxiv Microbiology@biorxiv-microbiol.bsky.social · 2y ago

UFMylation promotes orthoflavivirus infectious particle production https://www.biorxiv.org/content/10.1101/2025.01.09.632082v1

Reposting my offer for 1-1 mentoring for anyone… email me and we'll find a time! Especially happy to talk with those from diverse backgrounds and non-traditional career trajectories.

We have an open faculty search for TWO positions in microbiology and virology at the University of Illinois! We have world class core facilities and a fantastic collaborative group of young faculty...you could be next! Please re-post/skeet!

I am so excited to join the faculty in the Division of Immunobiology at Cincinnati Children's Hospital Medical Center in March 2025. My lab will study how RNA biology regulates and is regulated by infection and immunity. We'll be hiring at all levels in 2025 - stay tuned! www.gokhalelab.com

Cincinnati Children’s Research@cincyresearch.bsky.social · 2y ago

Excited that @nandangokhale.bsky.social plans to join the faculty at Cincinnati Children's in March! Check out the UW story about the study: www.eurekalert.org/news-release...

Cellular RNAs directly regulate the activity of an antiviral immune signaling complex www.science.org/doi/10.1126/... www.science.org/doi/10.1126/... @science.org @nandangokhale.bsky.social @ramlabuw.bsky.social

This Perspective by Sonja Best and Adam Hage puts tuning the MAVS signalosome by cellular mRNAs into context. buff.ly/4fxVMcx #Immunology @science.org

#Immunology out now @science.org An unstructured region within MAVS interacts with cellular, rather than viral, RNA. This alters how MAVS interacts with other proteins and influences antiviral responses. https://buff.ly/4grnf18 By @nandangokhale.bsky.social with @ramlabuw.bsky.social et al.

Our work on cellular RNA interactions with MAVS that promote antiviral signaling is finally live. So grateful to our indispensable collaborators as well as reviewers who helped to strengthen our work. #RNA #innateimmunity #virology @ramlabuw.bsky.social www.science.org/doi/10.1126/...

Cellular RNA interacts with MAVS to promote antiviral signaling

Antiviral signaling downstream of RIG-I–like receptors (RLRs) proceeds through a multi-protein complex organized around the adaptor protein mitochondrial antiviral signaling protein (MAVS). Protein co...

science.org

Time for our first post here 🥳 Our latest paper is online 🙌 We show that UV activates the ribotoxic stress response, which causes inflammation, cell death and thickening in skin. Read about a role for the RSR separate from DNA damage signaling in response to sunburn: ✨☀️ www.cell.com/molecular-ce...

The ribotoxic stress response drives acute inflammation, cell death, and epidermal thickening in UV-irradiated skin in vivo

The acute skin reaction to sunburn, encompassing keratinocyte cell death, inflammation, and epidermal thickening, has traditionally been ascribed to DNA damage responses. Using a mouse model deficient...

cell.com

Really interesting work by Rachel van Gelder and the @ramlabuw.bsky.social lab! #RNA #immunity

Ram Savan@ramlabuw.bsky.social · 2y ago

Rachel Van Gelder, a recently minted PhD from the lab, shows IL-2 splices IFNG mRNA introns, increasing protein levels via NF-κB signaling. She uncovers a novel role for cytokine-induced splicing in immunity! 🧬 #RNA #Immunology #Research www.embopress.org/doi/full/10....

CHMC Division of Immunobiology is hiring Assistant Professors. You can have a lab next to mine if you like.

#omap4lyfe. We've had a great experience using this protocol-- five stars, highly recommend. @pspeck-enthusiast.bsky.social

Dave Shechner@shechnerlab.bsky.social · 2y ago

It's my great pleasure to present the next big preprint from SheqLab! An exciting application of our O-MAP platform that I hope will transform the study of nuclear architecture. If you've ever wanted to dissect the subnuclear "neighborhood" around an individual locus, read on! (1/30)

O-MAP is a gift that will keep on giving!

Dave Shechner@shechnerlab.bsky.social · 2y ago

It's my great pleasure to present the next big preprint from SheqLab! An exciting application of our O-MAP platform that I hope will transform the study of nuclear architecture. If you've ever wanted to dissect the subnuclear "neighborhood" around an individual locus, read on! (1/30)

It's my great pleasure to present the next big preprint from SheqLab! An exciting application of our O-MAP platform that I hope will transform the study of nuclear architecture. If you've ever wanted to dissect the subnuclear "neighborhood" around an individual locus, read on! (1/30)

Hi everyone! New to Bluesky, but happy to share the final chapter of my PhD @uconnhealth.bsky.social out today in Nature Immunology! Here, we uncovered a noncanonical function of the glucose transporter GLUT4 in regulating RLR signaling in muscle and adipocytes www.nature.com/articles/s41...

UBXN9 governs GLUT4-mediated spatial confinement of RIG-I-like receptors and signaling - Nature Immunology

Wang and colleagues show that in skeletal muscle cells and cardiomyocytes, the glucose transporter GLUT4 is a negative regulator of RIG-I-like receptor signaling during viral infection by redistributi...

nature.com

Victim of its success the Virology and Virus-Host interaction starter pack got packed (150 users) so I created #2 ! Reach out if you want to be included ! go.bsky.app/6bSDmrW

A starter pack for all virologists out there on the blue side ! Might be missing some people but it’s a good start ! go.bsky.app/DmphBCT

Excited to see many in the bacterial pathogenesis community joining here in the last few weeks, so here's a Starter Pack to help make connections. Reply/DM to be added to this or future Packs. #Microsky go.bsky.app/VH64BaY

I’ve made a Starter Pack of #innateimmunity and #inflammation researchers to follow! Please contact me to get added or to suggest others to add. We are just getting started 😎 #immunosky #academicchatter go.bsky.app/QqJ9AgB

Shouldn’t it spontaneously assemble and fuse with other starter packs?

Bede Portz@ysptsps.bsky.social · 2y ago

Is there a phase separation/condensate starter pack?

Excited to share our latest work! In it, we develop a new method for studying RNA localization via proximity labeling: OINC-seq! In contrast to other proximity-based methods, labels deposited on RNAs are read directly by sequencing without the need for biotinylation. biorxiv.org/cgi/content/...

Couldn’t find a virology starter pack so here’s one to get the ball rolling. Repost/reply if you are a virologist so I can find and add you to the list! go.bsky.app/SinqoJU

I console myself with the fact I’m on this 🤣 go.bsky.app/FGTURr3